Withdrawal: Preventive Effect of &lt;i&gt;Morinda citrifolia&lt;/i&gt; Fruit Juice on Neuronal Damage Induced by Focal Ischemia

Harada, Shinichi; Hamabe, Wakako; Kamiya, Kohei; Satake, Toshiko; Yamamoto, Junichiro; Tokuyama, Shogo

doi:10.1248/bpb.32.405

Cited by 45 publications

(58 citation statements)

References 19 publications

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“…The experimental transient focal ischemia mouse model was generated by performing MCAO, as previously described (20). Briefly, the left MCA was occluded for 2 h by inserting an 8-0 nylon monofilament with a thin silicon coat (Provil ® novo Medium; Heraeus Kulzer, Hanau, Germany) through the common carotid artery followed by reperfusion while the mice were under isoflurane anesthesia.…”

Section: Middle Cerebral Artery Occlusion (Mcao) and Reperfusionmentioning

confidence: 99%

Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage

2011

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Abstract. Orexin-A is a newly identified neuropeptide expressed in the lateral areas of the hypothalamus that plays a role in various physiological functions, including regulation of glucose metabolism. We have previously reported that the development of post-ischemic glucose intolerance is one of the triggers of ischemic neuronal damage. Therefore, the aim of this study was to determine the effects of orexin-A on the development of post-ischemic glucose intolerance and ischemic neuronal damage. Male ddY mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h. Neuronal damage was estimated by histological and behavioral analysis after MCAO. Intracerebroventricular administration of orexin-A (2.5, 25, or 250 pmol/mouse) significantly and dose-dependently suppressed the development of post-ischemic glucose intolerance on day 1 after MCAO and neuronal damage on day 3 after MCAO. In the liver and skeletal muscle, the expression levels of insulin receptor were decreased, whereas those of gluconeogenic enzymes were increased on day 1 after MCAO. Furthermore, these expressions were completely recovered to normal levels by orexin-A and were reversed by the administration of SB334867, a specific orexin-1 receptor antagonist. These results suggest that regulation of post-ischemic glucose intolerance by orexin-A suppressed cerebral ischemic neuronal damage.

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Section: Middle Cerebral Artery Occlusion (Mcao) and Reperfusionmentioning

confidence: 99%

Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage

2011

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“…10 Harada et al inspected the impact of the juice of Morinda citrifolia (Noni juice) on the brain damage brought about by ischemic stress in mice. 11 In our past study we reported the antiepileptic activity of Morinda citrifolia Linn fruit extract against seizures instigated by Maximal Electro Shock (MES) technique in rats. 12 Köktürk et al assessed the neuroprotective impacts of Morinda citrifolia L. (Rubiaceae), regularly known as Noni, and memantine on hydrocephalus-actuated neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

Jeyabalan¹,

Subramanian²,

Cheekala³

et al. 2017

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Background: Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer's, dementia, seizure and Parkinsonism. Morinda citrifolia (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. Objective: The present study is focused to identify the neuroprotective activity of Morinda citrifolia fruit extract (MCFE) on in vitro and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer's disease. Methods: Acetylcholinesterase inhibition assay was performed by in vitro & ex vivo methods as described by Ellman et al. In vitro antioxidant assay of the extract was performed by DPPH free radical scavenging activity & nitric oxide scavenging activity. Statistical analysis used: Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using GraphPad Prism software. Results: By performing in vitro antioxidant assay the IC 50 value of the standard quercetin was found to be 46.22 µg/ml as compared to the MCFE which has an IC 50 value of 43.14 µg/ml for DPPH free radical scavenging activity. Similarly the IC 50 value of the standard ascorbic acid was found to be 81.85 µg/ml as compared to the MCFE which has an IC 50 value of 148.0 µg/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by in vitro method and the IC 50 value of MCFE and neostigmine was found to be 31.84 µg/ml & 19.71 µg/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both in vitro and ex vivo techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase. Key words:Morinda citrifolia, Noni, Acetylcholinesterase, Neuroprotective activity, in vitro, ex vivo. Key Messages: The present study investigated the neuroprotective activity of Morinda citrifolia and it was identified by both in vitro and ex vivo techniques that the phytoconstituents in the plant can improve the learning and memory function by inhibiting the acetylcholinesterase. Further the antioxidant potential of the plant was also evident from the DPPH and nitric oxide scavenging activity. Future studies may be designed for chronic administration of Morinda citrifolia to further investigate the effect on in vivo experimentation and also to identify the safety and efficacy parameters at both preclinical and clinical stages.

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“…It is known that oxidative stresses, such as generation of damaging reactive oxygen species, will lead to cell death under ischemic condition. In addition, it is reported that ischemic neuronal damage could be restored by vitamins and polyphenols, both of which have antioxidative properties (39).…”

Section: Discussionmentioning

confidence: 99%

Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats

Ol¹,

Kanbak²,

İlhan³

et al. 2017

Erciyes Med J

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Objective: Isoproterenol (iso)-induced myocardial infarction is a widely used experimental model to study the beneficial effects of many drugs. Morinda citrifolia (noni) has traditionally been used for treating many diseases. Low-dose aspirin may have been protected heart tissueThis study aimed to investigate the possible protective effects of noni (20%) and low-dose aspirin (30 mg/kg) against iso-induced acute myocardial infarction in male Wistar rats. Materials and Methods:Rats were divided into control, iso, iso+noni, iso+aspirin, and iso+aspirin+noni groups (n=8). Myocardial infarction was induced by subcutaneous injection of iso (100 mg/kg) for two consecutive days. Iso-induced rats showed increased serum Creatine kinase-muscle brain CK-MB activity. The effects of noni (20%) and low-dose aspirin (30 mg/kg) were evaluated in response to iso-induced changes, Malondialdehyde (MDA), Superoxide Dismutase (SOD), Catalase (CAT), DNA fragmentation, caspase-3, and cathepsins B and L.Results: Oral treatment with 20% noni juice and low-dose aspirin (30 mg/kg) for 7 days significantly decreased apoptotic markers such as DNA fragmentation, caspase-3, and cathepsins B and L; increased antioxidant enzymes such as SOD and catalase activities; and decreased MDA levels. Conclusion:We propose that the protective effect, antiapoptotic and antioxidant mechanisms of noni and low dose aspirin may be on iso-induced myocardial infarction.

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Withdrawal: Preventive Effect of <i>Morinda citrifolia</i> Fruit Juice on Neuronal Damage Induced by Focal Ischemia

Cited by 45 publications

References 19 publications

Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage

Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats

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