WITHDRAWN: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer

Hao, Yibin; Shan, Guoyong; Kang, Nan

doi:10.1016/j.sjbs.2017.01.014

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The safety of AFT in the context of breast reconstruction is still a matter of controversy. A meta-analysis, as a statistical analysis method of evidence-based medicine, aims to increase the sample size by comprehensively analyzing the research results of multiple small samples on the same subject, thus improving the research efficiency of the original results and making the conclusions more representative ( 14 ). It is crucial to offer breast cancer patients information on the benefits and risks of AFT to further improve their quality of life.…”

Section: Introductionmentioning

confidence: 99%

The prognosis outcomes of autologous fat transfer for breast reconstruction after breast cancer surgery: a systematic review and meta-analysis of cohort studies

Tian¹,

Chu²,

Zhang³

et al. 2022

Gland Surg

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Background: Autologous fat transfer (AFT) is a minimally invasive technique that employs a patient's own fat to correct disfiguring sequelae for breast reconstruction in postoperative breast cancer patients. However, the results of studies on this topic were controversial. In order to explore the effect of AFT on breast reconstruction after breast cancer surgery, we included cohort studies and conducted a meta-analysis.Methods: A literature search was conducted using PubMed, Embase, Cochrane Library, and Web of Science databases for relevant studies published up to September 14, 2020. We identified the eligible studies based on the PICOS principles, populations (patients diagnosed with breast cancer), interventions (patients undergoing AFT after breast cancer surgery), controls (patients who did not receive AFT after breast cancer surgery), outcomes [local recurrence (LR) rate, regional recurrence (RRR) rate, locoregional recurrence (LRR) rate, distant metastasis rate, systemic recurrence (SR) rate, and total death rate], study design (cohort studies). The I 2 statistic was conducted to estimate heterogeneity. Relative risks (RRs) with 95% confidence intervals (CIs) were presented to evaluate whether AFT compromises oncological safety in breast reconstruction. Funnel plots and Egger's test were adopted to assess publication bias. Quality assessment for the included studies using the Newcastle-Ottawa Scale (NOS).Results: Twenty-two cohort studies involving 9,971 postoperative patients with breast cancer were identified, with 3,622 receiving AFT being the experimental group, and 6,349 not receiving AFT in the control group. The overall quality of the included studies was rated as high. No significant differences in the

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Section: Introductionmentioning

confidence: 99%

The prognosis outcomes of autologous fat transfer for breast reconstruction after breast cancer surgery: a systematic review and meta-analysis of cohort studies

Tian¹,

Chu²,

Zhang³

et al. 2022

Gland Surg

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“…Zhang Jihua’s team predicted the action target of traditional Chinese medicine (Tian et al, 2017). Hao Yibin’s team conducted in-depth exploration of colorectal cancer regulation mechanism (Hao et al, 2017). The research group plans to build a more complete colorectal cancer regulatory network on this basis by combining p42.3.…”

Section: Introductionmentioning

confidence: 99%

Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein

Hao¹,

Zhang²,

Shan³

et al. 2017

Saudi Journal of Biological Sciences

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to establish regulatory network of colorectal cancer involving p42.3 protein and to provide theoretical evidence for deep functional exploration of p42.3 protein in the onset and development of colorectal cancer. with protein similarity algorithm, reference protein set of p42.3 cell apoptosis was built according to structural features of p42.3. GO and KEGG databases were used to establish regulatory network of tumor cell apoptosis involving p42.3; meanwhile, the largest possible working pathway that involves p42.3 protein was screened out based on Bayesian network theory. Besides, GO and KEGG were used to build regulatory network on early diagnosis gene markers for colorectal cancer including WWOX, K-ras, COX-2, p53, APC, DCC and PTEN, at the same time, a regulatory network of colorectal cancer cell apoptosis which involves p42.3 was established. cell apoptotic regulatory network that p42.3 participates in primarily consists of Bcl-2 family genes and the largest possible pathway is p42.3 → FKBP → Bcl-2 centered as FKBP protein. Combined with colorectal cancer regulatory network that involves early diagnosis gene markers, it can be predicted that p42.3 is most likely to regulate the colorectal cancer cell apoptosis through FKBP → Bcl-2 → Bax → caspase-9 → caspase-3 pathway. the colorectal cancer apoptosis network based on p42.3 established in the study provides theoretical evidence for deep exploration of p42.3 regulatory mechanism and molecular targeting treatment of colorectal cancer.

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WITHDRAWN: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer

Cited by 2 publications

References 21 publications

The prognosis outcomes of autologous fat transfer for breast reconstruction after breast cancer surgery: a systematic review and meta-analysis of cohort studies

The prognosis outcomes of autologous fat transfer for breast reconstruction after breast cancer surgery: a systematic review and meta-analysis of cohort studies

Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein

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