WITHDRAWN: Preoperative duloxetine to prevent postoperative shoulder pain after gynecologic laparoscopy: a randomized controlled trial

Elfadl, Ghada Mohammad Abo; Osman, Ayman Mamdouh; Ghalyoom, Mina Fayez; Al-Rab, Nawal Abdel-Aziz Gad; Bahloul, Mustafa

doi:10.1016/j.bjane.2021.07.035

Cited by 4 publications

(15 citation statements)

References 20 publications

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“…The primary outcome of the included study is pain scores at different timelines, 24,25,28,32,36,39–41,43,44,46,48 total rescue analgesia requirements at different timelines, 20–22,26,27,29,33,35,38,42,43,46,47 Quality of recovery score QoR‐40, 23,31 cognitive functions, 28 duration of spinal anesthesia 30 and time to first rescue analgesia 32,37,45 …”

Section: Resultsmentioning

confidence: 99%

“…Pain assessment in studies was done with pain scores at different timelines at rest and movement, 20–30,33–41,48 time to first rescue analgesia, 21,26,28,29,32–35,37,38,41 and total Rescue analgesia consumed. Rescue analgesia in different studies was morphine, 20,22,23,26,30,31,35,38,39,42,48 pethidine, 21,29,36 fentanyl, 27 paracetamol, 21,31,34,41,43–45,47 diclofenac sodium, 43 oral celecoxib 46–48 and tramadol 40,44–46 …”

Section: Resultsmentioning

confidence: 99%

“…Other outcomes besides pain assessment studied were patient satisfaction 21,25,26,29,33,39,41 on the Likert scale and Quality of recovery score (QoR‐40 score) at the different timelines, 23,31,35,36,38 postoperative anxiety, and depression, 25 compliance with drugs intake 25,47 postoperative cognitive functions, 28 serum cortisol level, 29 duration of spinal block, 30 lengths of hospital stay, 31,39 time to ambulation, 33 Ramsay sedation score, 35,44 Aldrete score, 35 time to unassisted mobilization, 43 hemoglobin and thromboelastogram parameters for risk of bleeding, 46 orthopedic recovery outcome 47 and range of movement 48 …”

Section: Resultsmentioning

confidence: 99%

“…32,37,45 Pain assessment in studies was done with pain scores at different timelines at rest and movement, [20][21][22][23][24][25][26][27][28][29][30][33][34][35][36][37][38][39][40][41]48 time to first rescue analgesia, 21,26,28,29,[32][33][34][35]37,38,41 and total Rescue analgesia consumed. Rescue analgesia in different studies was morphine, 20,22,23,26,30,31,35,38,39,42,48 pethidine, 21,29,36 fentanyl, 27 paracetamol,…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Duloxetine or placebo was given for 1 day just before the operation, 29,32,[34][35][36]38,40,41,43,44 for two consecutive days around the day of surgery, 20,23,[26][27][28]31,37,42,45 for 5-7 days, 24,30,33,46 for 2 weeks, 22,25,39,47,48 and 2 weeks before to 2 weeks after surgery. 21 The choice of anesthesia was general anesthesia , 21,22,24,[26][27][28][29][31][32][33][34][35][36][37][41][42][43][44][45][46]48 general anesthesia or subarachnoid block, 59 gene...…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Postoperative acute pain management with duloxetine as compared to placebo: A systematic review with meta‐analysis of randomized clinical trials

Govil¹,

Arora²,

Parag³

et al. 2023

Pain Practice

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BackgroundDuloxetine has been used as an adjunct in multimodal analgesia for acute postoperative pain in clinical studies. This meta‐analysis aims to conclude whether oral duloxetine, when given perioperatively, is any better than a placebo in managing postoperative pain. Effects of duloxetine on postoperative pain scores, time to first rescue analgesia, postoperative rescue analgesia consumption, side effects attributable to duloxetine, and patient satisfaction profile were assessed.MethodMEDLINE, Web of Science, EMBASE, Scholar Google, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched with keywords including “Duloxetine” AND “postoperative pain”, “Duloxetine” AND “acute pain” and with “Duloxetine” till October 2022. This meta‐analysis included randomized clinical trials in which perioperative duloxetine 60 mg per oral was administered not more than 7 days before surgery and for at least 24 after surgery but not more than 14 days after surgery. All RCTs in which the comparator is placebo and outcomes related to analgesic efficacy like pain scores, opioid consumption, and side effects of duloxetine until 48 h postoperatively were included. Data were extracted from the studies and a risk of bias summary was formed using the Cochrane Collaboration tool. Effect sizes were given as standardized mean differences for continuous outcomes and risk ratios (RR) by the Mantel–Haenszel test for the categorical outcome. Confirmation of publication bias was done by Egger's regression test (p < 0.05). If publication bias or heterogeneity was detected, the trim‐and‐fill method was used to calculate the adjusted effect size. Sensitivity analysis was done by leaving one out method after excluding the study with a high risk of bias. Subgroup analysis was done based on the type of surgery and gender. The study was prospectively registered in the PROSPERO under the registration number CRD42019139559.Findings29 studies with 2043 patients met the inclusion criteria and were reviewed for this meta‐analysis. Postoperative pain scores at 24 h [Std. Mean Difference (95% CI); −0.69 (−1.07, −0.32)] and at 48 h [−1.13 (−1.68, −0.58)] are significantly less with duloxetine (p‐value < 0.05). Time to first rescue analgesia was significantly more in patients where duloxetine was administered [1.27 (1.10, 1.45); p‐value > 0.05]. Opioid consumption up to 24 h [−1.82 (−2.46, −1.18)] and 48 h [−2.48 (−3.46, −1.50)] was significantly less (p‐value < 0.05) in patients who received duloxetine. Complications and recovery profiles were similar in patients receiving either duloxetine or a placebo.InterpretationBased on GRADE findings, we conclude that there is low to moderate evidence to advocate the use of duloxetine for managing postoperative pain. Further trials are needed to replicate or refute these results based on robust methodology.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Postoperative acute pain management with duloxetine as compared to placebo: A systematic review with meta‐analysis of randomized clinical trials

Govil¹,

Arora²,

Parag³

et al. 2023

Pain Practice

View full text Add to dashboard Cite

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The effects of a short-term perioperative duloxetine treatment on post-colectomy pain: A randomized, controlled clinical trial

Erdmann¹,

Gerber²,

Gaspareto³

et al. 2022

Journal of Clinical Anesthesia

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Comparing the effect of transcutaneous electrical nerve stimulation and massage therapy on post laparoscopic shoulder pain: a randomized clinical trial

Mottahedi,

Shamsi,

Babani

et al. 2023

BMC Musculoskelet Disord

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Background Shoulder pain is a common clinical problem after laparoscopic surgeries. The use of non-pharmacological massage and transcutaneous electrical nerve stimulation (TENS) as an adjunct to routine treatment is increasing to provide optimal pain relief. Therefore, we aimed to determine the effect of TENS and massage therapy on post laparoscopic shoulder pain (PLSP). Methods This study was conducted on 138 patients who underwent laparoscopic cholecystectomy. Patients were randomly divided into three groups: massage plus conventional pharmacological treatment (n = 46), TENS plus conventional pharmacological treatment (n = 46), and conventional pharmacological treatment (n = 46). Massage and TENS were performed three consecutive times after the patients regained consciousness in the inpatient wards. The intensity of Shoulder pain was evaluated using a visual analog scale before and 20 min after each treatment. Results Both massage therapy and TENS led to a significant reduction in the intensity of PLPS compared to the control group in all three measured times (p < 0.001). However, no significant difference was observed between TENS and massage at any of the three-time points. Conclusions This study’s findings demonstrated that massage and TENS techniques could reduce PLSP. Trial registration Registered in the Iranian registry of clinical trials (www.irct.ir) in 05/02/2022 with the following code: IRCT20200206046395N1.

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WITHDRAWN: Preoperative duloxetine to prevent postoperative shoulder pain after gynecologic laparoscopy: a randomized controlled trial

Cited by 4 publications

References 20 publications

Postoperative acute pain management with duloxetine as compared to placebo: A systematic review with meta‐analysis of randomized clinical trials

Postoperative acute pain management with duloxetine as compared to placebo: A systematic review with meta‐analysis of randomized clinical trials

The effects of a short-term perioperative duloxetine treatment on post-colectomy pain: A randomized, controlled clinical trial

Comparing the effect of transcutaneous electrical nerve stimulation and massage therapy on post laparoscopic shoulder pain: a randomized clinical trial

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