Witkop′s tooth and nail syndrome: A multifaceted approach to dental management

Abstract

Witkop's tooth and nail syndrome is a rare autosomal dominant disorder of ectodermal dysplasia characterized by hypodontia and nail dysplasia. Mutations in MSX-1 have been shown to be associated with this syndrome. There is failure of development and eruption of the dentition. Tooth shape may vary; the most common forms are conical and narrow crowns. The nails may be spoon shaped and slow growing and affect both finger and toe nails. The nail involvement is more severe in childhood. The present case describes a 14-year-old boy who showed the characteristic features of Witkop's syndrome. A multifaceted approach to the dental management of the patient is discussed.

Tooth and Nail Syndrome- A rare case report

“…The affected woman in the current case study is normothermic, has normal hair development and pattern, but has damaged (dysplastic) toenails and fingernails. [5] An intraoral clinical and radiographic examination revealed that 18 permanent teeth were missing due to birth defects. The extraoral and intraoral findings of the current case report are comparable to those of previously reported research.…”