Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression

Nagy, Irina I.; Railo, Antti; Rapila, Risto; Hast, Terhi; Sormunen, Raija; Tavi, Pasi; Räsänen, Juha; Vainio, Seppo

doi:10.1093/cvr/cvp254

Cited by 75 publications

(74 citation statements)

References 44 publications

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“…Of interest, Wnt11R is a true ortholog of other vertebrate Wnt11 genes . Genetic analyses have demonstrated a role for Wnt11 in the ureteric branching of the mouse kidney (Majumdar et al, 2003) and in heart morphogenesis (Nagy et al, 2010), but its role in NC development has not been examined. Consistent with the role in NC specification, Xenopus Wnt11R is expressed in the neural plate, adjacent to the NC territory (Matthews et al, 2008a).…”

Section: Discussionmentioning

confidence: 99%

Neural crest specification by noncanonical Wnt signaling and PAR-1

Ossipova

Sokol

2011

Development

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SUMMARYNeural crest (NC) cells are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal transition and migrate to diverse locations in vertebrate embryos to give rise to many cell types. Multiple signaling factors, including Wnt proteins, operate during early embryonic development to induce the NC cell fate. Whereas the requirement for the Wnt/b-catenin pathway in NC specification has been well established, a similar role for Wnt proteins that do not stabilize bcatenin has remained unclear. Our gain-and loss-of-function experiments implicate Wnt11-like proteins in NC specification in Xenopus embryos. In support of this conclusion, modulation of b-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premigratory NC. Morpholino-mediated depletion experiments suggest that Wnt11R, a Wnt protein that is expressed in neuroectoderm adjacent to the NC territory, is required for NC formation. Wnt11-like signals might specify NC by altering the localization and activity of the serine/threonine polarity kinase PAR-1 (also known as microtubule-associated regulatory kinase or MARK), which itself plays an essential role in NC formation. Consistent with this model, PAR-1 RNA rescues NC markers in embryos in which noncanonical Wnt signaling has been blocked. These experiments identify novel roles for Wnt11R and PAR-1 in NC specification and reveal an unexpected connection between morphogenesis and cell fate.

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Section: Discussionmentioning

confidence: 99%

Neural crest specification by noncanonical Wnt signaling and PAR-1

Ossipova

Sokol

2011

Development

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“…74,75 This putative functional redundancy might explain why a loss of Wnt11 results in an early cardiac phenotype in Xenopus 49,51 but not in the mouse with later phenotypes. 76,77 Slightly later, however, it might be Wnt2b that regulates proliferation of the common cardiac progenitor through a Wnt/␤-catenin pathway. 78 enter the heart tube either from the anterior site giving rise to the right ventricle and the OFT or they can enter from the posterior site contributing to the atria and the inflow tract region.…”

Section: Cardiac Specification: Positive Influence Of Noncanonical Wnmentioning

confidence: 99%

“…A detailed analysis indicated defects in N-cadherin/␤-catenin mediated cell adhesion as well. 76 Similarly, Wnt5a promotes N-cadherin-mediated cell adhesion in cardiac myocytes. 94 Besides N-cadherin, the cell adhesion molecule DM-GRASP also has been shown to be regulated by noncanonical Wnt signaling in Xenopus.…”

Section: From the Tubular Heart Tube To The Four Chambers Wnt Signalimentioning

confidence: 99%

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

Gessert

Kühl

2010

Circulation Research

360

310

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Understanding heart development on a molecular level is a prerequisite for uncovering the causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac regeneration or that involve the differentiation of resident cardiac progenitor cells or patient-specific induced pluripotent stem cells will also benefit tremendously from this knowledge. Wnt proteins have been shown to play multiple roles during cardiac differentiation and development. They are extracellular growth factors that activate different intracellular signaling branches. Here, we summarize our current understanding of how these factors affect different aspects of cardiogenesis, starting from early specification of cardiac progenitors and continuing on to later developmental steps, such as morphogenetic processes, valve formation, and establishment of the conduction system. (Circ Res. 2010;107:186-199.)

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“…The role of Wnt11 in cell motility was reported related to the directional movements of the cells in the assembling ventricular wall by modulating cell adhesion in connection with changes in the cytoskeleton (Nagy et al, 2010). A common theme is that Wnt11 acts locally to control the turnover of proteins involved in cell-cell and cell-substrate adhesion and thereby facilitate coordinated cell migration (Katoh, 2009;Uysal and Kypta, 2011).…”

Section: Discussionmentioning

confidence: 99%

Differential Wnt11 Expression Related to Wnt5a in High- and Low-grade Serous Ovarian Cancer: Implications for Migration, Adhesion and Survival

Jannesari-Ladani

Hossein²,

Izadi-Mood³

2014

Asian Pacific Journal of Cancer Prevention

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Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression

Abstract: We conclude that Wnt-11 signalling serves as a critical cell adhesion cue for the organization of the cardiomyocytes in the developing ventricular wall, which is essential for the establishment of a functional heart.

Cited by 75 publications

References 44 publications

Neural crest specification by noncanonical Wnt signaling and PAR-1

Neural crest specification by noncanonical Wnt signaling and PAR-1

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

Differential Wnt11 Expression Related to Wnt5a in High- and Low-grade Serous Ovarian Cancer: Implications for Migration, Adhesion and Survival

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