1994
DOI: 10.1101/gad.8.2.174
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Wnt-3a regulates somite and tailbud formation in the mouse embryo.

Abstract: Amphibian studies have implicated Wnt signaling in the regulation of mesoderm formation, although direct evidence is lacking. We have characterized the expression of 12 mammalian Wnt-genes, identifying three that are expressed during gastrulation. Only one of these, Wnt-3a, is expressed extensively in cells fated to give rise to embryonic mesoderm, at egg cylinder stages. A likely null allele of Wnt-3a was generated by gene targeting. All Wiit-3fl~/Wnt-3a~ embryos lack caudal somites, have a disrupted notochor… Show more

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Cited by 731 publications
(481 citation statements)
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“…9 in Sasaki and Hogan, 1993;Takada et al, 1994;Rossant, personal communication). Namely, a number of genes are expressed in patterns that coincide with the four levels of the primitive streak defined in the present study.…”
Section: Comparison Between the Mouse And Chick Primitive-streak Fatementioning
confidence: 97%
“…9 in Sasaki and Hogan, 1993;Takada et al, 1994;Rossant, personal communication). Namely, a number of genes are expressed in patterns that coincide with the four levels of the primitive streak defined in the present study.…”
Section: Comparison Between the Mouse And Chick Primitive-streak Fatementioning
confidence: 97%
“…The expression of the Wnt1, -3a, -6, and -7b genes, known to trigger the Wnt canonical pathway in which beta-Catenin is a key player, may provide autocrine and paracrine Wnt signals to the inner cell mass cells. Neither the gene inactivation of Wnt1 nor that of Wnt3a or Wnt7b leads to preimplantation defects, suggesting that these Wnts may play redundant roles during patterning of the preimplantation embryo (McMahon and Bradley, 1990;Takada et al, 1994;Parr et al, 2001).…”
Section: Multiple Specific Wnt Expression Patterns In the Blastocystmentioning
confidence: 99%
“…Other mouse mutants with short tails and defective somitogenesis comprise the Wnt3a and Wnt5a knockout mouse (Takada et al, 1994;Yamaguchi et al, 1999). The zebrafish mutant ogon, encoding a zebrafish homologue of Secreted Frizzled (Yabe et al, 2003), and pipetail, a hypomorphic allele of Wnt5a (Rauch et al, 1997), also exhibit short tails.…”
Section: Ror2 Is Essential For Somite Formationmentioning
confidence: 99%