Wnt-dependent Regulation of the E-cadherin Repressor Snail

Yook, Jong In; Li, Xiaoyan; Ota, Ichiro; Fearon, Eric R.; Weiss, Stephen J.

doi:10.1074/jbc.m413878200

Cited by 396 publications

(431 citation statements)

References 44 publications

Supporting

Mentioning

415

Contrasting

Unclassified

Order By: Relevance

“…Previously, Monaghan et al showed distinct and elevated expression patterns of DKK-1, -2 and -3 in tissues that mediate epithelialmesenchymal transformations and suggested that they participate in the process of EMT (Monaghan et al, 1999). Additionally, regulation of snail expression and activity by Wnt could be shown (Laux et al, 2004;Bachelder et al, 2005;Yook et al, 2005). These data is supported by our findings that snail-1 expression is downregulated after expression of DKK-3.…”

Section: Discussionsupporting

confidence: 89%

Expression of Dickkopf genes is strongly reduced in malignant melanoma

et al. 2006

View full text Add to dashboard Cite

The Dickkopf (DKK) genes were originally identified as factors inducing head formation in Xenopus. The genes code for inhibitors that are involved in Wnt signaling. We speculate that loss of DKK expression plays a role in development or progression of malignant melanoma. Thus, we evaluated melanoma cell lines and tissue samples of malignant melanoma for loss of DKK, especially DKK-3 transcription. We found that DKK-1, -2 and -3 were downregulated or lost in all cell lines and in most of the tumor samples analysed. Reduced DKK-3 expression occurred as early as in primary tumors detected by both immunohistochemical and reverse transcription-polymerase chain reaction RT-PCR analysis. Functional assays with stable DKK-3 transfected cell lines revealed that DKK-3 expression increased cell-cell adhesion and decreased cell migration. Further, downregulation of fibronectin, snail-1 and re-expression of E-cadherin was found in the DKK-3 expressing cell clones supporting a role of DKK-3 in tumor progression. Our studies thus indicate that loss of DKK-3 expression may contribute to melanoma progression.

show abstract

Section: Discussionsupporting

confidence: 89%

Expression of Dickkopf genes is strongly reduced in malignant melanoma

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Consistent with this observation, some of these repressors have been found expressed specifically at the invasive front of human invasive hepatocellular and breast carcinoma [15,16]. The expression of these repressors seems to be highly regulated by pathways, including canonical Wnt signaling, TGF-b (see below), FGF, EGF, Stat3 and nuclear factor k-B (NFk-B) signaling [17][18][19]). Notably, Snail1 is a highly unstable protein.…”

Section: Changes In Cell-cell and Cell-matrix Adhesionmentioning

confidence: 74%

Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

Kopfstein

Christofori

2006

Cell. Mol. Life Sci.

209

160

View full text Add to dashboard Cite

Abstract. The fatality of cancer predominantly results from the dissemination of primary tumor cells to distant sites and the subsequent formation of metastases. During tumor progression, some of the primary tumor cells as well as the tumor microenvironment undergo characteristic molecular changes, which are essential for the metastatic dissemination of tumor cells. In this review, we will discuss recent insights into pro-metastatic events occurring in tumor cells themselves and in the tumor stroma. Tumor cell-intrinsic alterations include the loss of cell polarity and alterations in cell-cell and cell-matrix Cell. Mol. Life Sci. 63 (2006) 449-468 1420-682X/06/040449-20 DOI 10.1007/s00018-005-5296-8 © Birkhäuser Verlag, Basel, 2006 adhesion as well as deregulated receptor kinase signaling, which together support detachment, migration and invasion of tumor cells. On the other hand, the tumor stroma, including endothelial cells, fibroblasts and cells of the immune system, is engaged in an active molecular crosstalk within the tumor microenvironment. Subsequent activation of blood vessel and lymph vessel angiogenesis together with inflammatory and immune-suppressive responses further promotes cancer cell migration and invasion, as well as initiation of the metastatic process.

show abstract

“…It is believed that during neural crest cell migration, degradation of Snail2 is controlled by polyubiquitination of the N-terminal part (Vernon and LaBonne, 2006). In addition, phosphorylation sites have been identified in Snail1 that control the nuclear localization and activity in both positive (Yang et al, 2005) and negative (Dominguez et al, 2003;Zhou et al, 2004;Yook et al, 2005) manners. However, similar sites do not appear to regulate Snail2 stability in vivo in Xenopus (Vernon and LaBonne, 2006).…”

Section: Discussionmentioning

confidence: 99%

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

Gouzi

Kim

Katsumoto

et al. 2011

Developmental Dynamics

141

124

View full text Add to dashboard Cite

During development, pancreatic endocrine cells are specified within the pancreatic epithelium. They subsequently delaminate out of the epithelium and cluster in the mesenchyme to form the islets of Langerhans. Neurogenin3 (Ngn3) is a transcription factor required for the differentiation of all endocrine cells and we investigated its role in their delamination. We observed in the mouse pancreas that most Ngn3-positive cells have lost contact with the lumen of the epithelium, showing that the delamination from the progenitor layer is initiated in endocrine progenitors. Subsequently, in both mouse and chick newly born endocrine cells at the periphery of the epithelium strongly decrease E-cadherin, break-down the basal lamina and cluster into islets of Langerhans. Repression of E-cadherin is sufficient to promote delamination from the epithelium. We further demonstrate that Ngn3 indirectly controls Snail2 protein expression post-transcriptionally to repress E-cadherin. In the chick embryo, Ngn3 independently controls epithelium delamination and differentiation programs. Developmental Dynamics 240:589-604,

show abstract

Wnt-dependent Regulation of the E-cadherin Repressor Snail

Cited by 396 publications

References 44 publications

Expression of Dickkopf genes is strongly reduced in malignant melanoma

Expression of Dickkopf genes is strongly reduced in malignant melanoma

Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

Contact Info

Product

Resources

About