2015
DOI: 10.1080/15476278.2015.1086052
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Wnt signaling induces epithelial differentiation during cutaneous wound healing

Abstract: ABSTRACT. Cutaneous wound repair in adult mammals typically does not regenerate original dermal architecture. Skin that has undergone repair following injury is not identical to intact uninjured skin. This disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development and thus we seek a deeper understanding of the role that Wnt signaling plays in the mechanisms of skin repair in both fetal and adult wounds. The influence of secrete… Show more

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Cited by 77 publications
(72 citation statements)
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“…The latter has been shown in bacteria-induced injury of the urogenital tract (97) during which activation of Wnt/beta-catenin signaling promotes the regenerative response to bacterial injury. This is well in line with the observation that Wnt signaling induces epithelial differentiation during cutaneous wound healing (98). …”
Section: Opposing Roles Of Wnt5a and Wnt/beta-catenin Signaling In Insupporting
confidence: 91%
“…The latter has been shown in bacteria-induced injury of the urogenital tract (97) during which activation of Wnt/beta-catenin signaling promotes the regenerative response to bacterial injury. This is well in line with the observation that Wnt signaling induces epithelial differentiation during cutaneous wound healing (98). …”
Section: Opposing Roles Of Wnt5a and Wnt/beta-catenin Signaling In Insupporting
confidence: 91%
“…β-catenin subsequently translocates to the nucleus to exert its effects as a transcriptional co-activator. (Houschyar, et al, 2015) This section will focus on the influence of Wnt signaling in wound healing as it pertains to scar formation. For more in-depth review of the role of Wnt signaling in tissue renewal and regeneration, the reader is directed to the following review article (Clevers, et al, 2014).…”
Section: Recent Advances In Scarless Wound Healing Researchmentioning
confidence: 99%
“…In the canonical wnt pathway, in absence of wnt ligand, β-catenin is degraded via complex of axin, apc and GSK3, p2a, CK1α. Alternatively, level of β-catenin can be stimulated by growth factor such as TGFβ in fibroblast which is released in early phase of wound repair [53]. Canonical wnt signaling involves accumulation and translocation of β-catenin into nucleus [53,54].…”
Section: Plos Onementioning
confidence: 99%
“…Alternatively, level of β-catenin can be stimulated by growth factor such as TGFβ in fibroblast which is released in early phase of wound repair [53]. Canonical wnt signaling involves accumulation and translocation of β-catenin into nucleus [53,54]. In the present study, exposure of 0.25 w/cm 2 532 nm laser, caused repression of axin2 which led to β-catenin stabilization and in turn β-catenin repressed its target gene ccnd1 associate with de-differentiation of epithelial cells.…”
Section: Plos Onementioning
confidence: 99%
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