Wnt/β-catenin signalling plays diverse functions during the process of fibrotic remodelling in the exocrine pancreas

Bläuer, Merja; Laaninen, Matias; Sand, Juhani; Laukkarinen, Johanna

doi:10.1016/j.pan.2019.02.003

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…Interestingly, this distribution pattern can be modeled in vitro. PSCs express β-catenin in monocultures, but when cocultured with PACs, the levels of SFRP4 increase compared to monoculture, and thus PSCs do not exhibit nuclear distribution of β-catenin (Blauer et al, 2019). The above indicates that, in terms of Wnt signaling, a monoculture of PSCs reflects advanced stages of fibrosis, whereas a co-culture of PACs-PSCs has the expression pattern seen in moderate fibrosis.…”

Section: Wnt Signaling Pathwaymentioning

confidence: 93%

“…The distribution of these factors is dependent on the condition of the tissue -that is it changes upon tissue damage and in fibrosis. An analysis of human samples revealed that in the non-fibrotic pancreatic tissue, β-catenin is mainly located at the cell membrane of PACs, inhibitory SFRP4 is present in these cells, and Wnt2 is expressed at a low level (Blauer et al, 2019). In moderate fibrosis, the expression of Wnt2 in PACs increases, and β-catenin can now be found in the acinar nuclei indicating transcriptional activation; whereas in advanced fibrosis, β-catenin mostly localizes to PSCs (Blauer et al, 2019).…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

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Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances

et al. 2020

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The interest in pancreatic stellate cells (PSCs) has been steadily growing over the past two decades due mainly to the central role these cells have in the desmoplastic reaction associated with diseases of the pancreas, such as pancreatitis or pancreatic cancer. In recent years, the scientific community has devoted substantial efforts to understanding the signaling pathways that govern PSC activation and interactions with neoplastic cells. This mini review aims to summarize some very recent findings on signaling in PSCs and highlight their impact to the field.

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Section: Wnt Signaling Pathwaymentioning

confidence: 93%

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances

et al. 2020

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“…Interestingly, this distribution pattern can be modeled in vitro. PSCs express ß-catenin in monocultures, but when co cultured with PACs, the levels of SFRP4 increase compared to monoculture, and thus PSCs do not exhibit nuclear distribution of ß-catenin (Blauer et al, 2019) . The above indicates that, in terms of W nt signaling, a monoculture of PSCs reflects advanced stages of fibrosis, whereas a co-culture of PACs-PSCs has the expression pattern seen in moderate fibrosis.…”

Section: Wnt Signaling Pathwaymentioning

confidence: 98%

“…The distribution of these factors is dependent on the condition o f the tissue -that is it changes upon tissue damage and in fibrosis. An analysis of human samples revealed that in the non-fibrotic pancreatic tissue, ß-catenin is mainly located at the cell membrane o f PACs, inhibitory SFRP4 is present in these cells, and W nt2 is expressed at a low level (Blauer et al, 2019) . In moderate fibrosis, the expression of W nt2 in PACs increases, and ß-catenin can now be found in the acinar nuclei indicating transcriptional activation; whereas in advanced fibrosis, ß-catenin mostly localizes to PSCs (Blauer et al, 2019) .…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Spotlight on the Background Actors - Physiology and Pathophysiology of Supporting, Accessory and Less Common Cell Types in the Gastrointestinal Tract

2020

Frontiers Research Topics

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Frontiers is m ore than ju st an open-access publisher o f scholarly articles: it is a pioneering approach to the w orld o f academia, radically im proving the way scholarly research is managed. The grand vision o f Frontiers is a w orld w here all people have an equal o p p o rtu n ity to seek, share and generate knowledge. Frontiers provides im m ediate and perm anent online open access to all its publications, but this alone is not enough to realize o ur grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a m u lti-tie r and interdisciplinary set o f open-access, online journals, prom ising a paradigm shift fro m the current review, selection and dissem ination processes in academ ic publishing. All Frontiers journals are driven by researchers fo r researchers; therefore, they constitute a service to the scholarly com m unity. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific com m unities of scholars, and gradually clim bing up to broader public understanding, thus serving the interests o f the lay society, too. Dedication to QualityEach Frontiers article is a landm ark o f the highest quality, thanks to genuinely collaborative interactions between authors and review editors, w h o include some o f the world's best academicians. Research m ust be certified by peers before entering a stream o f know ledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the m ost rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the m ost outstanding research, evaluated w ith no bias fro m both the academ ic and social p oint o f view. By applying the m ost advanced inform ation technologies, Frontiers is catapulting scholarly publishing into a new generation. W hat are Frontiers Research Topics? Frontiers Research Topics are very popular tradem arks o f the Frontiers Journals Series: they are collections o f at least ten articles, all centered on a particular subject. W ith the ir unique m ix o f varied co n trib u tio n s fro m O riginal Research to Review Articles, Frontiers Research Topics unify the m ost influential researchers, the latest key findings and historical advances in a hot research area! Find o u t m ore on how to host y o u r ow n Frontiers Research Topic or co n tribute to one as an author by conta ctin g the Frontiers Editorial

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“…This dynamic process drives the fibrotic progression in CP [86,87]. The Wnt/β-catenin signaling pathway emerges as a pivotal participant in the course of pancreatic fibrosis and remodeling processes [88]. The Wnt signal is activated in damaged acinar cells, orchestrating acinar cell regeneration and proliferation, while beta-catenin activation of this pathway within both acinar cells and PSCs drives the fibrotic process [89,90].…”

Section: Acinar-cell-induced Activation Of Pscsmentioning

confidence: 99%

Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis

Kong,

Pan,

2024

Biomedicines

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In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs) emerge as central figures. These cells, initially in a dormant state characterized by the storage of vitamin A lipid droplets within the chronic pancreatitis microenvironment, undergo a profound transformation into an activated state, typified by the secretion of an abundant extracellular matrix, including α-smooth muscle actin (α-SMA). This review delves into the myriad factors that trigger PSC activation within the context of chronic pancreatitis. These factors encompass alcohol, cigarette smoke, hyperglycemia, mechanical stress, acinar cell injury, and inflammatory cells, with a focus on elucidating their underlying mechanisms. Additionally, we explore the regulatory factors that play significant roles during PSC activation, such as TGF-β, CTGF, IL-10, PDGF, among others. The investigation into these regulatory factors and pathways involved in PSC activation holds promise in identifying potential therapeutic targets for ameliorating fibrosis in chronic pancreatitis. We provide a summary of recent research findings pertaining to the modulation of PSC activation, covering essential genes and innovative regulatory mediators designed to counteract PSC activation. We anticipate that this research will stimulate further insights into PSC activation and the mechanisms of pancreatic fibrosis, ultimately leading to the discovery of groundbreaking therapies targeting cellular and molecular responses within these processes.

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Wnt/β-catenin signalling plays diverse functions during the process of fibrotic remodelling in the exocrine pancreas

Cited by 9 publications

References 46 publications

Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances

Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances

Spotlight on the Background Actors - Physiology and Pathophysiology of Supporting, Accessory and Less Common Cell Types in the Gastrointestinal Tract

Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis

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