Women In Steady Exercise Research (WISER) Sister: Study design and methods

Schmitz, Kathryn H.; Williams, Nancy I.; Kontos, Despina; Kurzer, Mindy S.; Schnall, Mitchell D.; Domchek, Susan M.; Galantino, Mary Lou; Hwang, Wei Ting; Morales, Knashawn H.; Wu, Shandong; DiGiovanni, Laura; Salvatore, Domenick; Fenderson, Desire’; Good, Jerene; Grant, Lorita L.; Bryan, Cathy; Adelman, Jess

doi:10.1016/j.cct.2014.12.016

Cited by 20 publications

(51 citation statements)

References 108 publications

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“…Complete study design and methods are available and have been previously published (18). In the Women In Steady Exercise Research (WISER) Sister study, conducted at the University of Pennsylvania (Philadelphia, PA), premenopausal women with an elevated risk for breast cancer were recruited nationally for a 5-menstrual-cycle-long exercise intervention.…”

Section: Methodsmentioning

confidence: 99%

“…Through these efforts, 1,025 women contacted the WISER Sister study team with interest in participating and were eligible on the basis of initial screening. Following full screening for eligibility, 217 women were eligible for the WISER Sister study, 162 women consented, 139 women were randomized, and 137 had available blood samples for adipokine analysis (18). Of the 137 women, 23% were local participants (residing within 75 miles of the University of Pennsylvania) and 77% were longdistance participants.…”

Section: Methodsmentioning

confidence: 99%

“…The high-dose exercise group started at 150 min/wk and increased 20 to 25 minutes every 2 weeks until reaching 300 minutes. Further detailed descriptions of the intervention and study parameters have been presented by Schmitz and colleagues (18).…”

Section: Methodsmentioning

confidence: 99%

“…Dietary intake was measured through 3-day dietary records, and participants were asked to maintain their normal caloric intake throughout the study. These metrics were completed at baseline and follow-up as previously described (18).…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Sturgeon

DiGiovanni

Good

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n ¼ 137) with an elevated risk for breast cancer.Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n ¼ 44) or high-dose exercise (300 min/wk; n ¼ 48) with a control group asked to maintain usual activity levels (n ¼ 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Sturgeon

DiGiovanni

Good

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Figure 1 presents the Consort flow diagram and final distribution of 139 randomized participants. Further details of recruitment are provided elsewhere [27]. …”

Section: Methodsmentioning

confidence: 99%

Dose–response effects of aerobic exercise on estrogen among women at high risk for breast cancer: a randomized controlled trial

Schmitz

Williams

Kontos

et al. 2015

Breast Cancer Res Treat

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Medical and surgical interventions for elevated breast cancer risk (e.g., BRCA1/2 mutation, family history) focus on reducing estrogen exposure. Women at elevated risk may be interested in less aggressive approaches to risk reduction. For example, exercise might reduce estrogen, yet has fewer serious side effects and less negative impact than surgery or hormonal medications. Randomized controlled trial. Increased risk defined by risk prediction models or BRCA mutation status. Eligibility: Age 18–50, eumenorrheic, non-smokers, and body mass index (BMI) between 21 and 50 kg/m2. 139 were randomized. Treadmill exercise: 150 or 300 min/week, five menstrual cycles. Control group maintained exercise<75 min/week. Primary outcome: Area under curve (AUC) for urinary estrogen. Secondary measures: urinary progesterone, quantitative digitized breast dynamic contrast-enhanced magnetic resonance imaging background parenchymal enhancement. Mean age 34 years, mean BMI 26.8 kg/m2. A linear dose-response relationship was observed such that every 100 min of exercise is associated with 3.6 % lower follicular phase estrogen AUC (linear trend test, p = 0.03). No changes in luteal phase estrogen or progesterone levels. There was also a dose–response effect noted: for every 100 min of exercise, there was a 9.7 % decrease in background parenchymal enhancement as measured by imaging (linear trend test, p = 0.009). Linear dose–response effect observed to reduce follicular phase estrogen exposure measured via urine and hormone sensitive breast tissue as measured by imaging. Future research should explore maintenance of effects and extent to which findings are repeatable in lower risk women. Given the high benefit to risk ratio, clinicians can inform young women at increased risk that exercise may blunt estrogen exposure while considering whether to try other preventive therapies.

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Interventions for promoting habitual exercise in people living with and beyond cancer

Turner

Steed

Quirk

et al. 2018

Cochrane Database of Systematic Reviews

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Women In Steady Exercise Research (WISER) Sister: Study design and methods

Cited by 20 publications

References 108 publications

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Dose–response effects of aerobic exercise on estrogen among women at high risk for breast cancer: a randomized controlled trial

Interventions for promoting habitual exercise in people living with and beyond cancer

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