Women infected with human immunodeficiency virus type 1 have poorer assisted reproduction outcomes: a case-control study

Stora, C.; Epelboin, Sylvie; Devouche, Émmanuel; Matheron, Sophie; Epelboin, Loïc; Yazbeck, Chadi; Damond, Florence; Longuet, P; Dzineku, Frederick; Rajguru, Mandovi; Delaroche, Lucie; Mandelbrot, Laurent; Luton, Dominique; Patrat, Catherine

doi:10.1016/j.fertnstert.2015.12.138

Cited by 23 publications

(13 citation statements)

References 37 publications

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“…In a similar line of study, another group did not find any differences in AMH levels and antral follicles count between HIV-1-positive and non-infected women [28]. These authors did not note any differences in ovarian stimulation, duration, total gonadotropins units administered, except for a difference in E 2 levels, but lower pregnancy rates were observed [28], in line with the results we obtained in this work. Except for AMH levels that were reduced in HIV subgroup, no other differences were observed for the number of antral follicles and the concentrations of FSH in relation to controls, which suggests that all groups possess similar ovarian reserve.…”

Section: Discussionsupporting

confidence: 89%

“…The number of clinical pregnancies in HIV-positive women also did not change [13] [27]. In a similar line of study, another group did not find any differences in AMH levels and antral follicles count between HIV-1-positive and non-infected women [28]. These authors did not note any differences in ovarian stimulation, duration, total gonadotropins units administered, except for a difference in E 2 levels, but lower pregnancy rates were observed [28], in line with the results we obtained in this work.…”

Section: Discussionmentioning

confidence: 90%

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Fertility Care Provided by a Public Health Hospital to Viral-Infected Couples: A Case-Control Study

Figueiredo¹,

Correia²,

Pinto³

et al. 2021

OJOG

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Objective: To evaluate the results of ART (clinical pregnancies and baby home rates) in couples infected with HBV, HCV, HIV or mixed in a Referral center. Patients: The study is a retrospective case-control study comprising 1587 cycles/1064 couples in the control group and 237 cycles/164 couples in the infected group, submitted to in vitro fertilization, intracytoplasmic sperm injection and embryo transfer. Two branches from the infected group were created: the HIV subgroup, comprising couples with one or both partners infected with HIV-1 (84 cycles/67 couples), and the HCV subgroup, including at least one partner infected with HCV (45 cycles/29 couples). Results: The infected group presented higher infertility duration (P < 0.001) and so did the HCV subgroup (P < 0.001). Tubal infertility was increased in the infected group (P < 0.001), and in the HIV (P < 0.001) and HCV (P = 0.01) subgroups. Oocytes and oocytes in metaphase II numbers were lower in the infected group, but not in the HIV and HCV subgroups. Clinical pregnancy rate was lower in the infected group (25.74%) when compared to the control (34.66%), probably due to the contribution of HCV individuals (17.78%), but not of HIV (28.57%). Baby home rate was lower in the infected group (21.52%) relative to the control group (28.42%), but no differences were found in the HIV (27.38%) and HCV (15.56%) subgroups. Conclusions: Despite the low clinical pregnancy rate in the HCV subgroup, baby home rates did not change from control. These data seem promising for couples with viral infections who wish to conceive.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Fertility Care Provided by a Public Health Hospital to Viral-Infected Couples: A Case-Control Study

Figueiredo¹,

Correia²,

Pinto³

et al. 2021

OJOG

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“…In a women's age-adjusted study in 2005, Terriou et al (22) showed that the total gonadotropin dose, the duration of stimulation, and the cancellation rate were significantly higher, and the clinical pregnancy rate was much lower in the ''women HIV'' group compared with controls. In 2016, in a retrospective case-control study, Stora et al (19) compared 82 couples who were HIV-positive with 82 seronegative couples standardized on several criteria (age of the woman, etiology and type of infertility, the rank and technique of the IVF cycle). In the ''women HIV'' group, implantation rate, clinical pregnancy rate (by transfer and by oocyte retrieval), and live birth rate (by transfer) were significantly lower compared with those of controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

et al. 2021

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“…14 If conception is not achieved within 6 to 12 months, couples should be referred to a specialist for investigation as infertility rates are higher in the seropositive population with lower rates of implantation (10% vs 21%), pregnancy (12% vs 32%) and live-births (7% vs 19%) compared to uninfected controls. 15 Sperm washing followed by intrauterine insemination (IUI), in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is considered safe, with a recent meta-analysis summarizing more than 40 trials in assisted reproductive cycles revealed no documented cases of HIV transmission. 16 Regardless of method of conception, it is recommended that individuals living with HIV initiate cART and achieve viral suppression prior to pregnancy.…”

Section: Pregnancy Planning Considerationsmentioning

confidence: 99%

HIV Infection in Pregnant Women: A 2020 Update

Harris

Yudin

2020

Prenatal Diagnosis

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Acquired immunodeficiency syndrome (AIDS) was first described in 1981, and continues to be one of the worst global health pandemics in recorded history. Concerted international efforts have helped to increase awareness of human immunodeficiency (HIV) status, improve access to treatment and continuation of therapy to achieve viral suppression with a goal of ending the AIDS epidemic by 2030. The clinical outcomes for patients living with HIV on combined antiretroviral therapy are considerably improved with prolonged life expectancy and superior quality of life. Further, perinatal transmission rates have dramatically decreased with elimination of mother to child transmission of HIV in a growing number of countries worldwide. However, there have been significant reductions in the pace of progress in treatment expansion for pregnant women with failure to meet global targets in 2018. In this review, we will highlight recent advances and challenges ahead in 2020 for three areas of perinatal care for women with HIV in developed countries: (a) pregnancy planning considerations, (b) impact of antiviral medications on perinatal outcomes, and (c) infant feeding practices. The promise of a HIV-free generation is on the horizon and continued international efforts in preventing perinatal transmission are an important component of this achievement.

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Women infected with human immunodeficiency virus type 1 have poorer assisted reproduction outcomes: a case-control study

Cited by 23 publications

References 37 publications

Fertility Care Provided by a Public Health Hospital to Viral-Infected Couples: A Case-Control Study

Fertility Care Provided by a Public Health Hospital to Viral-Infected Couples: A Case-Control Study

Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

HIV Infection in Pregnant Women: A 2020 Update

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