Women's reproductive health in the Sakha Republic (Yakutia)

Douglas, N.I.; Pavlova, Tatiana U; Бурцева, Т.Е.; Rad, Yana G; Петрова, П. Г.; Odland, Jon Øyvind

doi:10.3402/ijch.v73.25872

Cited by 5 publications

(5 citation statements)

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“…The interactions of the genes with induced abortions and chronic endometritis were analyzed for their possible effect on UL. Induced abortions and chronic endometritis were included in the analysis because (i) they were determined as risk factors for UL in the study sample (Table 1), (ii) induced abortions are a common birth control method of women in Russia as compared with other countries (Sedgh et al, 2007), and (iii) induced abortions are a common cause of post-abortion endometritis and, subsequently, chronic endometritis in Russian women (Douglas et al, 2014). The analysis was performed using MB-MDR with adjustment for covariates (age, BMI, family history of UL, and history of infertility) and multiple comparisons (1,000 permutations) as described above.…”

Section: Discussionmentioning

confidence: 99%

“…Induced abortions are common birth control method in Russia (and generally in the former USSR) (Sedgh et al, 2007;David et al, 2007;Douglas et al, 2014), and Russia (along with Cuba) is a leader by this indicator in the world (Sedgh et al, 2007). Induced abortions in the first trimester of pregnancy may cause multiple health complications, including PCOS, hyperprolactinemia, anovulatory menstruation, disorders of the luteal phase of the menstrual cycle, and postabortion endometritis (Douglas et al, 2014). Induced recurring abortions result in injuries of the uterus.…”

Section: Discussionmentioning

confidence: 99%

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Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma

et al. 2021

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Age at menarche (AAM) is an important marker of the pubertal development and function of the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of uterine leiomyoma (UL). However, while more than 350 loci for AAM have been determined by genome-wide association studies (GWASs) to date, no studies of these loci for their association with UL have been conducted so far. In this study, we analyzed 52 candidate loci for AAM for possible association with UL in a sample of 569 patients and 981 controls. The results of the study suggested that 23 out of the 52 studied polymorphisms had association with UL. Locus rs7759938 LIN28B was individually associated with the disease according to the dominant model. Twenty loci were associated with UL within 11 most significant models of intergenic interactions. Nine loci involved in 16 most significant models of interactions between single-nucleotide polymorphism (SNP), induced abortions, and chronic endometritis were associated with UL. Among the 23 loci associated with UL, 16 manifested association also with either AAM (7 SNPs) or height and/or body mass index (BMI) (13 SNPs). The above 23 SNPs and 514 SNPs linked to them have non-synonymous, regulatory, and expression quantitative trait locus (eQTL) significance for 35 genes, which play roles in the pathways related to development of the female reproductive organs and hormone-mediated signaling [false discovery rate (FDR) ≤ 0.05]. This is the first study reporting associations of candidate genes for AAM with UL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma

et al. 2021

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“…The potential sensitive periods include gestation (the final 20 weeks), infancy (birth to less than 2 years old), early childhood (2 years old to less than 7 years old), middle childhood (7 years old to less than 12 years old), and adolescence (12 years old to less than 17 years old). The timing of the potential sensitive periods was chosen based on previous literature describing changes in adipose tissue physiology across development and the timing of puberty among Yakut among women (Douglas et al, 2014). for each participant the mean temperature of each potential sensitive period.…”

Section: Selection Of Possible Sensitive Periodsmentioning

confidence: 99%

“…The potential sensitive periods include gestation (the final 20 weeks), infancy (birth to less than 2 years old), early childhood (2 years old to less than 7 years old), middle childhood (7 years old to less than 12 years old), and adolescence (12 years old to less than 17 years old). The timing of the potential sensitive periods was chosen based on previous literature describing changes in adipose tissue physiology across development and the timing of puberty among Yakut among women(Douglas et al, 2014).2.6 | Ambient temperature exposureThe NOAA Climate Data Online (NOAA National Center for Environmental Information) database maintains daily climate data captured at a weather station in Yakutsk, Russia beginning on March 3, 1888. We downloaded a data file that included average daily temperature in Yakutsk from 1950 to 2016.…”

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confidence: 99%

Evidence for a sensitive period of plasticity in brown adipose tissue during early childhood among indigenousSiberians

Lévy

Климова

Zakharova

et al. 2021

American J Phys Anthropol

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Objectives: Evolutionary theorists have debated the adaptive significance of developmental plasticity in organisms with long lifespans such as humans. This debate in part stems from uncertainty regarding the timing of sensitive periods. Does sensitivity to environmental signals fluctuate across development or does it steadily decline?We investigated developmental plasticity in brown adipose tissue (BAT) among indigenous Siberians in order to explore the timing of phenotypic sensitivity to cold stress.Methods: BAT thermogenesis was quantified using infrared thermal imaging in 78 adults (25 men; 33 women). Cold exposure during gestation, infancy, early childhood, middle childhood, and adolescence was quantified using: (1) the average ambient temperature across each period; (2) the number of times daily temperature dropped below À40 F during each period. We also assessed past cold exposure with a retrospective survey of participation in outdoor activities.Results: Adult BAT thermogenesis was significantly associated with the average temperature (p = 0.021), the number of times it was below À40 F (p = 0.026), and participation in winter outdoor activities (p = 0.037) during early childhood. Conclusions: Our results suggest that early childhood represents an important stage for developmental plasticity, and that culture may play a critical role in shaping the timing of environmental signals. The findings highlight a new pathway through which the local consequences of global climate change may influence human biology, and they suggest that ambient temperature may represent an understudied component of the developmental origins of health and disease.

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“…В исследовании, проведен ном Douglas N.l. et al [30] установлено, что артифи циальные аборты в первом триместре беременно сти обуславливают развитие гиперпролактинемии, синдрома поликистозных яичников, ановуляторной менструации, нарушений лютеиновой фазы менстру ального цикла, постабортного эндометрита, иммуно логических нарушений.…”

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Endometrial hyperplastic processes: etiopathogenesis, risk factors, polymorphism of candidate genes

Ponomarenko¹,

Polonikov²,

Churnosov³

2019

Akusherstvo i ginekologiia

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Вклад авторов. Пономаренко И.В., Полоников А.В., Чурносов М.И.: разработка дизайна исследования, получение дан ных для анализа, обзор публикаций по теме статьи, анализ полученных данных, написание текста рукописи. Конфликт интересов. Авторы заявляют об отсутствии возможных конфликтов интересов. Финансирование. Исследование проведено без спонсорской поддержки.

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Women's reproductive health in the Sakha Republic (Yakutia)

Cited by 5 publications

References 31 publications

Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma

Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma

Evidence for a sensitive period of plasticity in brown adipose tissue during early childhood among indigenousSiberians

Endometrial hyperplastic processes: etiopathogenesis, risk factors, polymorphism of candidate genes

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