Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone

Seifer, David B.; Scott, Richard T.; Bergh, Paul A.; Abrogast, Laura K; Friedman, Chad I.; Mack, Caryn K; Danforth, Douglas R.

doi:10.1016/s0015-0282(99)00193-4

Cited by 143 publications

(62 citation statements)

References 8 publications

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“…Patients with high serum levels of FSH on day 3 had granulosa cells of diminished capacity for secreting dimeric inhibins (9). Furthermore, women with declining ovarian reserve had decreased day 3 serum inhibin B levels despite having normal day 3 basal FSH levels (12). Inhibin B was found to be inversely correlated with age and FSH in women 39-52 years of age with regular menstrual cycles (10).…”

Section: Discussionmentioning

confidence: 99%

“…All of these tests are indirect measurements of ovarian reserve and have their own limitations. Inhibin B, a direct product of granulosa cells which might indicate the number of developing follicles, has been suggested as a direct biochemical marker of ovarian reserve (12,24). Recently, transvaginal ultrasound measurement of early follicular phase ovarian antral follicle counts and ovarian volume has been used to predict the response to ovulation induction in infertile women (14,15).…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that follicular phase inhibin B correlates inversely with both age and follicular phase FSH in perimenopausal women (10). Recent reports have demonstrated normal basal FSH but decreased serum inhibin B concentrations in women with poor ovarian responsiveness and clinical outcomes in assisted reproduction treatment cycles (11,12). Others have failed to find clinical value for inhibin B as an ovarian reserve test (13).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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“…Basal FSH, estradiol, and inhibin B have been used in IVF cycles to predict ovarian response and pregnancy rates, but they have limited use since they have a low predictive value, show cycle-dependent variations, may be subject to disparities between laboratory assays, and lack clear cut-off values [3,10,38,[54][55][56]. The number of antral follicles in the early follicular phase directly correlates with ovarian reserve [21] and decreased antral follicle numbers on basal ultrasound is a sign of ovarian aging, which is a feature observed prior to an increase in FSH levels [53].…”

Section: Introductionmentioning

confidence: 99%

Antral follicle count determines poor ovarian response better than anti-müllerian hormone but age is the only predictor for live birth in in vitro fertilization cycles

Mutlu

Erdem

et al. 2013

J Assist Reprod Genet

109

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Purpose To determine the predictive value of serum antimüllerian hormone (AMH) concentrations and antral follicle counts (AFC), on ovarian response and live birth rates after IVF and compare with age and basal FSH. Methods Basal levels of AMH, FSH and antral follicle count were measured in 192 patients prior to IVF treatment. The predictive value of these parameters were evaluated in terms of retrieved oocyte number and live birth rates. Results Poor responders in IVF were older, had lower AFC and AMH but higher basal FSH levels. In multivariate analysis AFC was the best and only independent parameter among other parameters and AMH was better than age and basal FSH to predict poor response to ovarian stimulation. Addition of AMH, basal FSH, age and total gonadotropin dose to AFC did not improve its prognostic reliability. Area under curve (AUC) for each parameter according to ROC analysis also revealed that AFC performed better in poor response prediction compared with AMH, basal FSH and age. The cut-off point for mean AMH and AFC in discriminating the best between poor and normal ovarian response cycles was 0.94 ng/mL (with a sensitivity of 70 % and a specificity of 86 %) and 5.5 (with a sensitivity of 91 % and a specificity of 91 %), respectively. However, age was the only independent predictor of live birth in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion AFC is better than AMH to predict poor ovarian response. Although AMH and AFC could be used to predict ovarian response they had limited value in live birth prediction. The only significant predictor of the probability of achieving a live birth was age.

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“…Anti-mullerian hormone (AMH) has a crucial role in maintaining ovarian reserve and modifying the follicle response to gonadotropins (11). Over the past decades, AMH is considered as one of the most reliable markers for ovarian reserve (12). Accumulating evidence in the literature suggests that vitamin D has been involved in ovarian reserve status, in vitro fertilization (IVF) outcomes, features of polycystic ovarian syndrome (PCOS) and endometriosis.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Görkem

Küçükler²,

Toğrul³

et al. 2017

Gynecol Obstet Reprod Med

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OBJECTIVE:To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns. STUDY DESIGN:This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxyprogesterone (17 (OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25 (OH) D) levels were analyzed. RESULTS:No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p>0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25 (OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively). CONCLUSIONS:There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.

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Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone

Cited by 143 publications

References 8 publications

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Antral follicle count determines poor ovarian response better than anti-müllerian hormone but age is the only predictor for live birth in in vitro fertilization cycles

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

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