Wood-Derived Hybrid Scaffold with Highly Anisotropic Features on Mechanics and Liquid Transport toward Cell Migration and Alignment

Yu, Peng; Wang, Dingqian; Chen, Zhuoxin; Cui, Qinke; Hu, Bohan; Zhang, Dongyue; Li, Yanyan; Chu, Hetao; Li, Jianshu

doi:10.1021/acsami.0c00646

Cited by 24 publications

(28 citation statements)

References 42 publications

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“…The ideal scaffolds for biological applications should provide biocompatibility, porosity, favorable mechanical properties, and bioresorbability. [232] Liu et al [233] prepared wood-derived hybrid scaffolds for bone tissue engineering. In this work, the aligned and porous DW was explored as a possible biomimetic scaffold via in situ deposition of hydroxyapatite (HAp) nanoparticles and vacuum inflated polycaprolactone (PCL).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Delignified Wood from Understanding the Hierarchically Aligned Cellulosic Structures to Creating Novel Functional Materials: A Review

Kumar

Jyske

Petrič

2021

Advanced Sustainable Systems

104

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performance environmentally friendly materials. This is because new processes will be required that allow control on all hierarchical levels. Wood is well defined as a biological engineering material with a complex hierarchical structure of organic material based on cellulose fibrils embedded in a matrix of hemicelluloses and lignin. [1,2] Wood has long been used as a construction material, as well as for pulp and paper production. These applications are highly dependent on the properties of lignin in wood. Removal of lignin is the key step in pulp and paper production, in addition to the conversion of biomass to liquid biofuels. Lignin was first discovered in wood by Anselme Payen in 1839, [3] as the incrusting material that must be removed to isolate the useful fibers in wood. Research pertaining to wood nanotechnology or functional wood materials is a rapidly emerging field. Functional wood materials are mostly fabricated by treating hierarchical natural templates (wood cell wall) by chemical and thermal means. These treatments selectively modify the wood cell wall structure (fine pore spaces and inner lumen surface area) for different applications. [4] The pore region and inner lumen surface have actively been modified to enhance the bulk properties of wood using organic chemicals, [5] inorganic chemicals, organic-inorganic chemicals, [6,7] and thermal methods. [8] Hybrid wood scaffolds have been prepared for diverse applications such as magnetic wood, [9,10] as well as wood-mineral and wood-metal hybrids. [11] Recent research on delignified wood (DW) has emerged from the classical pulp production method. In the preparation of DW, the embedded lignin is removed from the wood cell wall structure, while maintaining the natural hierarchical cellulosic structure. [12] Initially, DW was prepared in order to understand the unknown ultrastructure of wood cell walls. However, since 2015, research in this area has rapidly expanded to focus on the development of wood-based functional scaffolds. Within the literature, DW is predominantly prepared using alkaline delignification methods such as Kraft pulping (a mixture of sodium hydroxide (NaOH) and sodium sulfite (Na 2 SO 3 )) heated to boiling temperature), followed by bleaching using hydrogen peroxide (H 2 O 2 ) to remove the lignin. DW is chemically hydrophilic due to the presence and exposure of hydroxyl groups and possible sites for DW functionalization. DW scaffolds have been functionalized

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Tunable Woodmentioning

confidence: 99%

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Delignified Wood from Understanding the Hierarchically Aligned Cellulosic Structures to Creating Novel Functional Materials: A Review

Kumar

Jyske

Petrič

2021

Advanced Sustainable Systems

104

View full text Add to dashboard Cite

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Section: Biomedical Applicationsmentioning

confidence: 99%

“…The HEK293 cells successfully adhered and proliferated on hydrogel showing their excellent attachment and biocompatibility (Figure 15B). 120 Copyright 2020, American Chemical Society Bones in living animals possess high strength, anisotropic mechanical properties, porous structure for cell adhesion, and interconnected vessels for ionic and molecular transport, quite similar to wood. These features provide bone with oriented cell migration, exceptional proliferation, and in-situ vascularization features.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Transforming wood as next‐generation structural and functional materials for a sustainable future

Farid

Rafiq

Ali

et al. 2021

EcoMat

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Wood as an ecofriendly and renewable natural material has been extensively modified through various delignification protocols to preserve its natural structure and fiber direction. The increased porosity and permeability of wood scaffold thus provide excellent opportunities for material infiltration and densification. Wood features in hierarchical structure and biocompatibility are combined with cutting‐edge processings to overcome the weaknesses for vast applications. These new modifications have explored the great potentials of wood as a next‐generation structural and functional material. This review updates the state‐of‐the‐art physicochemical modifications and strategies to prepare versatile wood hydrogels, aerogels, membranes, and fibers with different physicochemical features. Discussion is elaborated to explore the immense breadth of wood as next‐generation material for applications in biomedical, energy storage, sensors, separation, and buildings. Finally, the main challenges of wood scaffold engineering are represented along with potential solutions and directions for developing wood‐based high‐performance structural and functional materials.

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Highly Elastic and Anisotropic Wood‐Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair

Chen

Sun

et al. 2023

Adv Healthcare Materials

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Scaffold‐based tissue engineering is a promising strategy to address the rapidly growing demand for bone implants, but developing scaffolds with bone extracellular matrix‐like structures, suitable mechanical properties, and multiple biological activities remains a huge challenge. Here, it is aimed to develop a wood‐derived composite scaffold with an anisotropic porous structure, high elasticity, and good antibacterial, osteogenic, and angiogenic activities. First, natural wood is treated with an alkaline solution to obtain a wood‐derived scaffold with an oriented cellulose skeleton and high elasticity, which can not only simulate collagen fiber skeleton in bone tissue but also greatly improve the convenience of clinical implantation. Subsequently, chitosan quaternary ammonium salt (CQS) and dimethyloxalylglycine (DMOG) are further modified on the wood‐derived elastic scaffold through a polydopamine layer. Among them, CQS endows the scaffold with good antibacterial activity, while DMOG significantly improves the scaffold's osteogenic and angiogenic activities. Interestingly, the mechanical characteristics of the scaffolds and the modified DMOG can synergistically enhance the expression of yes‐associated protein/transcriptional co‐activator with PDZ binding motif signaling pathway, thereby effectively promoting osteogenic differentiation. Therefore, this wood‐derived composite scaffold is expected to have potential application in the treatment of bone defects.

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Wood-Derived Hybrid Scaffold with Highly Anisotropic Features on Mechanics and Liquid Transport toward Cell Migration and Alignment

Cited by 24 publications

References 42 publications

Delignified Wood from Understanding the Hierarchically Aligned Cellulosic Structures to Creating Novel Functional Materials: A Review

Delignified Wood from Understanding the Hierarchically Aligned Cellulosic Structures to Creating Novel Functional Materials: A Review

Transforming wood as next‐generation structural and functional materials for a sustainable future

Highly Elastic and Anisotropic Wood‐Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair

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