While work-home interaction has been studied as a mediator between work factors and outcomes, less is known about work-home interaction as a mediator between work factors and mental and physical health. This study analyzes, from a Job Demands-Resources Model framework, whether negative work-home interaction mediates the relationship between job demands and mental/physical health complaints and whether positive work-home interaction mediates the relationship between job resources and health complaints. The statistical results supported our hypotheses, indicating that negative work-home interaction mediated the relationship between job demands (i.e., job insecurity, overload) and health complaints and that positive work-home interaction mediated the relationship between job resources (i.e., growth opportunities, advancement, organizational support) and mental health complaints. These findings broaden the JD-R framework by furthering the understanding of the mechanisms by which work-home interaction impacts an end outcome of interest to organizational psychology -employee health.Keywords work-life interaction, work factors, mental health, physical health.