Work-related musculoskeletal disorder (WRMD) complications are common in surgeons in general, but they are much higher in orthopedic surgeons. Numerous studies have explored the prevalence of WRMD among orthopedic surgeons internationally. However, little research has been carried out in Saudi Arabia on this matter. This review aimed to investigate it. A consistent and systematic search method was carried out to establish studies reporting the prevalence of WRMD among orthopedic surgeons in Saudi Arabia. The search comprised published research from 2000 to June 2024. Nine eligible studies were incorporated for analysis, which involved 490 participants. The prevalence documented in these studies has exhibited an upward trend in recent years, with reported rates ranging from 36% to 90.3%. The most frequent anatomic site is found to be the lower back. There is a significant association between WRMD, smoking, and increasing age. The prevalence of WRMD is elevated among orthopedics based on existing information in the literature. Hospitals, along with orthopedic residency programs offering orthopedic-specialized ergonomics or occupational injury lectures as well as workshops, may help equip surgeons with the necessary knowledge and skills for addressing this issue.