SUMMARY A retrospective cohort study of hypertensive employees to evaluate the impact of worksite antihypertensive treatment (WST) on cardiovascular disease (CVD) over S'/i years is reported. In a union-sponsored screening from August 1973 to February 1974 hypertensives (S= 160 and/or 95 mm Hg, or on medication) were identified. Of these, standardized criteria were met by 344, of whom 150 chose WST and 194 referred care (RC). The study groups were similar in age and sex composition. Union hospitalization and death records through 1982 revealed that CVD rates were fewer in WST than RC (3.0 vs 5.4/100 person-years; p < 0.01). By contrast, nonCVD rates were similar (8.1 vs 9.6). All-cause mortality rate in WST (0.89) was significantly (p < 0.05) lower than that in RC (1.81), as was the standard mortality ratio (55.1), based on U.S. mortality in 1978. CVD mortality was also lower (0.48 vs 1.10; NS). Persons with an initial blood pressure (BP) < 160/95 mm Hg had CVD event rates that were low and similar in WST and RC (3.6 vs 3.5). However, among those with elevated BP at entry, WST subjects fared significantly better than RC (2.8 vs 6.1; p < 0.001). Furthermore, in WST, previously treated patients with elevated BP at screening experienced one-third the CVD morbidity of their counterparts in RC (3.1 vs 10.8; p < 0.01). These results extend previous evidence that WST is an effective method to achieve BP control and demonstrate that this approach to the management of hypertension alters health outcomes favorably and significantly. had demonstrated that blood pressure (BP) control reduced the incidence of cardiovascular disease (CVD). '~3 At the same time, it was apparent that, despite availability of effective antihypertensive therapy, large numbers of identified and treated hypertensives were not achieving BP control. 4 " 7 In an attempt to overcome this deficiency, several modifications of conventional approaches to the management of hypertension evolved. Among these, programs to provide worksite-based antihypertension treatment attained widespread acceptance. Early studies demonstrated that systematic, protocol-directed care provided at the worksite, primarily under the aegis of a nurse, was safe, acceptable, and achieved a high degree of BP control.8 -9 Subsequent studies demonstrated that such systematic approaches to care were actually more effective than those conventionally available in the community.10 " The assumption that better BP control would be matched by greater reduction in CVD events has encouraged expansion of these and similar programs. However, recent findings indicate that greater BP control is not invariably associated with better health outcomes.12 Therefore, it is of more than academic interest to evaluate the effectiveness of worksite antihypertensive therapy in terms of its impact on CVD morbidity and mortality.To this end, we have applied the method of a retrospective cohort study to compare, over an 8'/2-year period, the morbidity and mortality of hypertensive storeworkers who joined a ...