Background: Worldwide, studies show that nurses’ health is related to some work environment factors; however, data on nursing tasks’ allocation and self-perceived workload are lacking, particularly for Lebanese nurses. We assessed the relationship of several work environment factors (overall workload and specific temporal, physical, mental, effort, frustration, and performance demands (NASA Task Load Index), staffing resources adequacy and leadership (Practice Environment Scale of Nursing Work Index), teamwork climate (Safety Attitudes Questionnaire), and nursing task allocation (Basel Extent of Rationing of Nursing Care) with self-reported musculoskeletal, cardiovascular, skin, and mental health diseases (Work Ability Index) and emotional exhaustion (Maslach Burnout Inventory) among Lebanese nurses. Methods: A cross-sectional self-report survey was distributed to all 289 registered nurses (RNs) in the medical, surgical, and pediatric units in two university-affiliated hospitals in Lebanon; 170 RNs provided complete data. Adjusted multivariable logistic regression models were used to assess the relationship of work environment factors with health conditions. Results: The most prevalent outcomes were musculoskeletal disease (69%), emotional exhaustion (59%), and mental health problems (56%); 70% of RNs had ≥2 and 35.29% had ≥4 co-occurring health problems. Musculoskeletal disorders were associated with higher overall (OR=1.36 (95%CI=1.03, 1.80)), temporal (OR=1.30 (95%CI=1.09, 1.55)), and physical demands (OR=1.20 (95%CI=1.03, 1.49)), more nursing tasks allocation to RNs (OR=1.11 (95%CI=1.01, 1.23)) and lower teamwork climate (OR=0.60 (95%CI=0.36, 0.98). Higher odds of mental/emotional problems were related to higher overall, temporal, frustration, and effort demands, and lower teamwork climate, performance satisfaction, and resources adequacy (increased odds ranging from 18% to 88%). Work-environment factors were related to higher co-occurrence of health problems. Conclusions: Results show high health burden and co-morbidity among Lebanese RNs and highlight the value of more comprehensive approaches towards improving many work environment factors (including team climate, various components of workload, resources, and nursing tasks’ allocation) to reduce this burden.