The coming decades are expected to be extremely challenging for organizations. On the one hand, there are the United Nations Sustainable Development goals to end poverty, protect the planet and improve the lives and prospects of everyone. On the other hand, organizations are expected to have to deal with an increasing number of megatrends and disruptors, many of which are already having an impact. To help organizations in their priority setting and decision-making so they can contribute to the development goals (specifically Goal 8: decent work and economic growth), a descriptive literature review was undertaken to identify which megatrends and disruptors will impact the future of organizations and in what ways they are expected do this. From the literature, thirteen megatrends and one disruptor emerged, and for each of these their postulated impact and consequences for organizations as described in the literature were gathered. The study reveals that there is ample attention given to megatrends in the academic literature but that not much can be found about dealing with disruptors. As a consequence, academic literature currently falls short in suggesting ways in which organizations can deal with disruptors. Managerial literature offers more suggestions in this respect.