Workshop on trichothecenes with a focus on DON: summary report

Larsen, John Christian; Hunt, Josephine P.; Perrin, Irène; Ruckenbauer, P.

doi:10.1016/j.toxlet.2004.04.020

Cited by 154 publications

(94 citation statements)

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“…Based on a much expanded database, the JECFA established a PMTI that was slightly lower in 2001 (Canady et al 2001). These factors (and others discussed in the following section) led to a series of recommendations on future research on DON at an ILSI-EU meeting held in Dublin (Larsen et al 2004). In relation to either increasing or decreasing the PMTDI, two issues were raised that deserve repeating.…”

Section: Introductionmentioning

confidence: 98%

“…The Provisional Maximum Tolerable Daily Intake (PMTDI) of the Joint Expert Committee on Food Additives and Contaminants of the World Health Organization/Food and Agricultural Organization (JECFA) for T-2/HT-2 toxin of 0.6 mg kg À1 bw has a larger safety factor than would normally be indicated. This is primarily due to a lack of experimental data (Larsen et al 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Under epidemic conditions, agronomic practices have modest impact on disease (Miller 1994;Schaafsma et al 2001;Hooker et al 2005;Koch et al 2006;Miller et al 1998). As far as can be seen, only countries that enforce clear requirements, such as reductions in Fusarium head blight (including DON measurements) (Wilde et al 2007), have been able to reduce toxin amounts in the harvested crop (Snijders 2004; see also Larsen et al 2004).…”

Section: Introductionmentioning

confidence: 99%

“…It was also agreed that the ethical problems in doing a human study would be profound, indicating that perhaps a non-human primate study would be desirable (Larsen et al 2004), in my opinion, would be less important than determining the mechanism of neurotoxicity. There are human clinical data available from the use of another trichothecene, DAS (also known as anguidine), as a chemotherapy agent in many studies.…”

Section: Introductionmentioning

confidence: 99%

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Mycotoxins in small grains and maize: Old problems, new challenges

Miller

2008

Food Additives & Contaminants: Part A

204

135

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This paper reviews the challenges relating to chronic contamination of small grains and maize with deoxynivalenol and related compounds, fumonisin and the use of ensiled cereals in cool dairy areas. Uncertainties in the tolerable daily intakes for deoxynivalenol and fumonisin are discussed as they have the potential to affect current regulatory limits. In addition, climate change is resulting in more extreme rainfall and drought events which favour formation of deoxynivalenol and fumonisin, respectively. The development and refinement of models for predicting mycotoxin accumulation from weather data will become an essential tool for managing these events. Such models are also important for providing timely food aid to developing countries, which experience increased occurrence of acute toxicities, especially in children. Chronic contamination of silage in some areas with some Penicillium toxins deserves more attention in terms of their economic effects and possible implications for the purity of milk.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mycotoxins in small grains and maize: Old problems, new challenges

Miller

2008

Food Additives & Contaminants: Part A

204

135

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“…El mecanismo de toxicidad de los tricotocenos, es la inhibición de la síntesis de proteínas, así como de la síntesis de ADN y ARN (18), por la unión de los TCT a la peptidil transferasa, parte integral de la subunidad 60S del ribosoma (3,19,20).…”

Section: Tricoticenos (Tct)unclassified

Micotoxinas en la Salud Pública

Duarte-Vogel¹,

Villamil-Jiménez²

2006

Rev. salud pública

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RESUMENLas micotoxinas constituyen un problema en el ámbito mundial por su alta incidencia y niveles de ocurrencia en los alimentos para humanos y animales. Las condiciones de colonización de los sustratos por hongos micotoxigénicos así como su posterior contaminación con micotoxinas juegan un papel fundamental en las estrategias de vigilancia y control. Entre los principales hongos micotoxigénicos se encuentran los géneros Aspergillus spp., Penicillium spp. y Fusarium spp. Dentro de las familias más importantes de micotoxinas se encuentran: las aflatoxinas, los tricoticenos, la ocratoxina A, las fumonisinas y la zearalenona. Los diferentes mecanismos de acción tóxica de estas micotoxinas constituyen un riesgo para la salud humana y animal constituyéndose en una problemática de salud pública. En Colombia la situación es compleja dada la deficiente investigación al respecto, los estudios realizados en el país han demostrado que la contaminación de alimentos por algunas micotoxinas es significativa y que se deben formular políticas sanitarias para afrontar este limitante. Se discute el riesgo potencial de las micotoxinas para la salud pública, las dificultades en el diagnóstico y la legislación así como las implicaciones en la seguridad e inocuidad alimentaria.Palabras Clave: Micotoxinas, salud pública, abastecimiento de alimentos, medicina veterinaria (fuente: DeCS, BIREME). ABSTRACT Micotoxins in Public HealthMycotoxins have become a worldwide problem due to their high incidence and levels of occurrence in human food and animal feed. The conditions for colonising substrates by mycotoxigenic fungus and later contamination by mycotoxins play an important role in surveillance and control strategies. The main mycotoxigenic funguses are the Aspergillus spp., Penicillium spp. and 129

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Deoxynivalenol as potential modulator of human steroidogenesis

Urbanek

Habrowska-Górczyńska

Kowalska

et al. 2018

J of Applied Toxicology

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Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.

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Workshop on trichothecenes with a focus on DON: summary report

Cited by 154 publications

References 0 publications

Mycotoxins in small grains and maize: Old problems, new challenges

Mycotoxins in small grains and maize: Old problems, new challenges

Micotoxinas en la Salud Pública

Deoxynivalenol as potential modulator of human steroidogenesis

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