Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes

Yoshino, Mihoko; Yoshino, Jun; Smith, Gordon I.; Stein, Richard I.; Bittel, Adam J.; Bittel, Daniel C.; Reeds, Dominic N.; Sinacore, David R.; Cade, W. Todd; Patterson, Bruce W.; Cho, Kevin; Patti, Gary J.; Mittendorfer, Bettina; Klein, Samuel

doi:10.1016/j.cmet.2022.08.012

Cited by 11 publications

(10 citation statements)

References 71 publications

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“… 2 , 8 , 9 The degree of weight loss observed by Yoshino et al. 1 (17% from baseline) is also very high compared to other studies in the field, which report losses of ∼1%–5% from baseline. It is also striking that every subject in the intensive group lost weight, with the lowest amount of weight loss being 6% and the highest being 29%.…”

Section: Main Textmentioning

confidence: 65%

“…In a recent randomized controlled trial by Yoshino et al., 1 adults with obesity and type 2 diabetes were assigned to one of two work-based interventions: intensive lifestyle therapy or standard care. The intensive therapy group met weekly with a dietitian to receive personalized diet and behavioral weight loss counseling.…”

Section: Main Textmentioning

confidence: 99%

“…Challenges aside, the study by Yoshino et al. 1 highlights the potential of worksite wellness programs to assist employees in managing their weight and improving metabolic health outcomes. This trial suggests that intensive work-based programs can play a critical role in helping to combat the obesity and diabetes epidemic.…”

Section: Main Textmentioning

confidence: 99%

“… In a randomized controlled trial, Yoshino et al. 1 examined the effects of a worksite-based intensive lifestyle therapy on body weight, glycemic control, and diabetes remission, in adults with obesity and type 2 diabetes. …”

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confidence: 99%

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Worksite-based intensive lifestyle therapies for diabetes remission

Varady

Lin

Oddo

2022

Cell Reports Medicine

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Section: Main Textmentioning

confidence: 65%

Section: Main Textmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

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confidence: 99%

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Worksite-based intensive lifestyle therapies for diabetes remission

Varady

Lin

Oddo

2022

Cell Reports Medicine

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“…Note that the time stamps in OhioT1DM dataset are pre-processed to avoid privacy leakage, hence they do not represent the real collection time. Inspired by observed fluctuation of metabolic reaction rates in oral glucose tolerance test (OGTT) (49), we adopted a time-varying parameters setting for SBINN to improve the flexibility of our model. Interestingly, while patient 588 and patient 591 followed similar insulin infusion and carb intakes, the only lifestyle difference in the exercise intensity seemingly changed the outcomes of their glucose management (Fig.…”

Section: Resultsmentioning

confidence: 99%

Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes

Deng

Arao

Mantzoros

et al. 2022

Preprint

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Due to insufficient insulin secretion, patients with type 1 diabetes mellitus (T1DM) are prone to blood glucose fluctuations ranging from hypoglycemia to hyperglycemia. While dangerous hypoglycemia may lead to coma immediately, chronic hyperglycemia increases patients' risks for cardiorenal and vascular diseases in the long run. In principle, an artificial pancreas - a closed-loop insulin delivery system requiring patients manually input insulin dosage according to the upcoming meals - could supply exogenous insulin to control the glucose levels and hence reduce the risks from hyperglycemia. However, insulin overdosing in some type 1 diabetic patients, who are physically active, can lead to unexpected hypoglycemia beyond the control of common artificial pancreas. Therefore, it is important to take into account the glucose decrease due to physical exercise when designing the next-generation artificial pancreas. In this work, we develop a deep reinforcement learning algorithm using a T1DM dataset, containing data from wearable devices, to automate insulin dosing for patients with T1DM. In particular, we build patient-specific computational models using systems biology informed neural networks (SBINN), to mimic the glucose-insulin dynamics for a few patients from the dataset, by simultaneously considering patient-specific carbohydrate intake and physical exercise intensity.

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Long‐Term High‐Fat Diet Decreases Renal Insulin‐Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway

Huang

Chen

et al. 2023

Molecular Nutrition Food Res

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Scope Long‐term high‐fat diet (HFD) causes insulin resistance, which is a primary etiological factor in the development of obesity and type 2 diabetes mellitus. Impaired insulin clearance is not only a consequence but also a cause of insulin resistance. The kidney is a major site of insulin clearance, where the insulin‐degrading enzyme (IDE) plays a vital role in the proximal tubule. Thus, the study investigates the role of renal IDE in the regulation of insulin resistance in HFD‐induced obese mice. Methods and results Twenty four‐weeks of HFD in C57BL/6 mice causes insulin resistance and impaires insulin clearance, accompanied by a decrease in renal IDE expression and activity. Palmitic acid decreases IDE mRNA and protein expressions in HK‐2 cells. RNA‐Seq analysis found that the PPAR pathway is involved. 24‐weeks of HFD decreases renal PPARγ, but not PPARα or PPARβ/δ mRNA expression. The inhibition of IDE expression by palmitic acid is prevented by the PPARγ agonist rosiglitazone. The amount of PPARγ bound to the promoters of IDE is decreased in palmitic acid‐treated cells. Rosiglitazone improves insulin clearance and insulin resistance and increases renal IDE expression in HFD fed‐mice. Conclusion Long‐term HFD decreases renal IDE expression and activity, and causes insulin resistance, which involves PPARγ.

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Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes

Cited by 11 publications

References 71 publications

Worksite-based intensive lifestyle therapies for diabetes remission

Worksite-based intensive lifestyle therapies for diabetes remission

Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes

Long‐Term High‐Fat Diet Decreases Renal Insulin‐Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway

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