Worldwide incidence of cervical lesions: a systematic review

Ting, Jie; Rositch, Anne F.; Taylor, Stephen; Rahangdale, Lisa; Soeters, Heidi M.; Sun, Xuezheng; Smith, Jennifer S.

doi:10.1017/s0950268814001356

Cited by 19 publications

(21 citation statements)

References 85 publications

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“…HPV 16 is described as responsible for the majority of HPV-associated cancers [3,4,6,17]. Our results demonstrated that HPV 16 was the most frequent type found in women from South Bahia (29%, 95% CI 20·7-38·9), similar with findings reported by Oliveira-Silva in Rio de Janeiro (28%).…”

Section: Discussionsupporting

confidence: 89%

“…The incidence rates of cervical cancer have declined over the past three decades in most developing countries, due mainly to prevention programs implemented. Methods that allow early screening are extremely important for defining treatment and containing the infection [3][4][5][6][7]. The high prevalence found in this study could be associated with the combination of different methodologies employed, the sampling number and the sample source (public health units).…”

Section: Discussionmentioning

confidence: 98%

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Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Gadelha

Dmv

et al. 2017

Epidemiol. Infect.

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The aim of this study was to determine the prevalence and risk factors for human papillomavirus (HPV) infection in the Southern region of the State of Bahia, evaluating the performance of alternative complementary methods for cervical lesion detection. Cervical samples from women who attended healthcare units were collected and diagnosed by visual inspection, cervical cytology and nested polymerase chain reaction (PCR). Moreover, hemi-nested PCR was performed to detect different HPV genotypes. The prevalence of HPV infection was 47·7%, with genotype 16 detected in most cases. Infection was associated with dyspareunia and bleeding (P < 0·001, odds ratio (OR) 5·6, 95% confidence interval (CI) 2·815-11·14) and hormonal contraceptive use (P = 0·007, OR 2·33, 95% CI 1·25-4·34). There was a positive correlation between positive PCR and positive visual inspection, cervical cytology and symptoms reported. Furthermore, visual inspection was twice as specific, and had a greater positive predictive value than cytology. We showed a high prevalence of HPV infection in Southern Bahia, with HPV 16 being the most common type, and visual inspection being most effective at detecting HPV lesions, corroborating the suggestion that it can be applied in routine gynecologic examinations for low-income populations.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Gadelha

Dmv

et al. 2017

Epidemiol. Infect.

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“…There is a gap of 10–20 years between pre-cancer and cancer which offers an opportunity to screen, detect and treat pre-cancer and avoid its progression to cancer. Immunocompromised women, however, progress more frequently and more quickly to pre-cancer and cancer [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Ahmed

Bensumaidea

Ashankyty

2015

Infect Agents Cancer

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BackgroundIdentification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer.MethodologyA total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).ResultsOf the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %. Conclusion: HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

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“…In the year 2018, 570,000 new cases of CC and 311,000 CC-associated deaths were reported worldwide. Intriguingly, 87 % of all cases occurred in developing countries [2]. The Xinjiang region has one of the highest rates of CC incidence in China, and the CC incidence can be up to 3.4 times greater in Uyghur woman than in Han women [3][4].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of GNB2L1 is associated with poor prognosis in cervical cancer patients

Qi¹,

Xu²,

Tuerxun³

et al. 2019

Preprint

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Background: Among women, cervical cancer (CC) is the fourth most prevalent cancer worldwide. Multiple bio-makers have been identified for tumor diagnosis and prognosis. However, no single bio-maker for CC detection exists that is both highly sensitive and specific. In this report, we explored the role of guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1) in CC progression in Uyghur women. Methods: In the present study, 132 patients with cervical squamous cell carcinoma (CSCC), 56 cases with cervical intraepithelial neoplasia (CIN) were enrolled. GNB2L1 mRNA and protein expression levels were analyzed in CSCC, CIN, and normal cervical (NC) tissues and in CC cell lines using qRT-PCR, western blot, and immunohistochemistry. Stable GNB2L1-knockdown CC cells (shGNB2L1) were also created and lipid accumulation was measured with Oil Red O staining. Additionally, changes in GNB2L1 gene copy number were investigated with qRT-PCR and sequencing. A gene regulatory network was constructed using the STRING database. Finally, patient survival was assessed with Kaplan‑Meier and log-rank tests. Results: Our results indicated that GNB2L1 mRNA and protein are overexpressed in CSCC tumor tissues when compared to CIN and NC tissues. GNB2L1 expression was associated with the degree of cell differentiation (P = 0.001), lymph node metastasis (P = 0.049), and the clinical stage (P = 0.017). Oil Red O staining showed that lipid levels were lower in shGNB2L1 cells, and that GNB2L1 DNA copy number in CC tissues (29,7200 ± 9,815.061) was significantly higher when compared to NC tissues (19,5100 ± 5,676.392 [T=-2.770, P = 0.009]). Furthermore, patients with CSCC and high GNB2L1 expression demonstrated shorter overall survival times when compared to patients with low GNB2L1 expression (P = 0.002). Multivariate analysis indicated that GNB2L1 overexpression is an independent prognostic factor in patients with CSCC. Conclusions: Overexpression of GNB2L1 may contribute to tumor progression; therefore, it is a potential prognostic biomarker for CSCC patients.

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Worldwide incidence of cervical lesions: a systematic review

Cited by 19 publications

References 85 publications

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Overexpression of GNB2L1 is associated with poor prognosis in cervical cancer patients

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