Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis

Qin, Jiabi; Sheng, Xiaoqi; Wu, Di; Gao, Shiyou; You, Yu; Yang, Tubao; Wang, Hua

doi:10.1007/s00404-016-4250-3

Cited by 136 publications

(119 citation statements)

References 74 publications

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“…A policy of single-embryo transfer in stimulated cycles becomes more popular and is currently the most effective measure to reduce the incidence of multiple pregnancies [24]. With an increasing implementation of a policy of single-transfer embryo, multiple pregnancies have reduced dramatically [27], but is still an outcome of ART that is undesirable.…”

Section: Discussionmentioning

confidence: 99%

Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

Silva

Silveira

Bertoldi

et al. 2020

BMC Pregnancy Childbirth

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Background: Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this study was to compare maternal and child-health outcomes after ART relative to natural conception. Methods: A population-based birth cohort study was carried out among pregnant women expected to deliver in 2015 in Pelotas, southern Brazil. Maternal outcomes included pregnancy complications and gestational weight gain. Gestational age, weight, intrauterine growth restriction, length and head circumference, and 1-min and 5-min Apgar, as well as health problems at birth and breastfeeding were defined as offspring outcomes. Statistical analyses were performed using linear and logistic regression. G-formula was used to perform mediation analysis. Results: The study included 4252 babies born by spontaneously pregnancies and 23 babies born after ART. Adjusted analyses showed that children conceived from ART presented lower means of gestational age (p = 0.001), birth weight (p = 0.002), length (p < 0.001), and head circumference at birth (p = 0.02). However, more than 90% of the effect of ART over these outcomes was mediated by multiple pregnancy. Conclusion: Our findings suggest that the possible negative effect on the child-health outcomes is due mainly to the higher incidence of multiple pregnancies and not because of ART. The reasons for the increase in adverse pregnancy outcomes associated with ART singleton pregnancies are still uncertain and warrants further research. Further large-population studies are needed to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

Silva

Silveira

Bertoldi

et al. 2020

BMC Pregnancy Childbirth

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“…It has been reported that the rates of stillbirths and neonatal deaths in IVF/ICSI cycles are 0.3%–1.6% and 0.3%–1.1% respectively (Bay, Boie, & Kesmodel, 2019; Magnusson et al, 2018; Qin et al, 2017; Wisborg, Ingerslev, & Henriksen, 2010). In our retrospective study, the rates of stillbirths and neonatal deaths were not significantly different between the two groups and within the range reported in the literatures.…”

Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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The present study assessed the influences of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional in vitro fertilisation cycles. This retrospective study analysed 427 and 2,728 cycles from the normal sperm morphology rate <4% and ≥4% group respectively. The clinical (total fertilisation failure, clinical pregnancy, implantation and abortion) and neonatal (sex, gestational age, preterm birth, birthweight, low birth weight, live births and birth defects of newborns) outcomes were compared. The rate of total fertilisation failure in the normal sperm morphology rate <4% group was significantly higher compared with that in the normal sperm morphology rate ≥4% group (2.8% versus 1.2%, p = .012). Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% significantly increased the total fertilisation failure rate but did not affect the clinical or neonatal outcomes.

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“…In our selection, the risk estimation was reported as OR for 15 studies [18,29,33,35,[38][39][40][41]52], RR for six studies [19,31,32,36,46,51], SIR for four studies [27,30,43,50], and HR for seven studies [17,44,[47][48][49]53,54]. [27,32,38,40,41], twenty-two studies reported tumors occurring in children aged <15 years [16,18,19,28,[30][31][32][34][35][36][38][39][40][41][42][43]45,[50][51]…”

Section: Study Characteristicsmentioning

confidence: 99%

“…According to the literature [5,54], the risk of pregnancy and neonatal birth adverse outcomes is increased by factors associated with ART procedures, such as the medications used to induce ovulation or to maintain the pregnancy in the early stages, the culture media composition, the length of time in culture, the freezing and thawing of embryos, the potential for polyspermic fertilization, the delayed fertilization of the oocyte, altered hormonal environment at the time of implantation, and the manipulation of gametes and embryos.…”

Section: Soft Tissue and Other Extraosseous Sarcomasmentioning

confidence: 99%

Cancer Risk in Children and Young Adults (Offspring) Born after Medically Assisted Reproduction: A Systematic Review and Meta-Analysis

Chiavarini

Ostorero

Naldini

et al. 2019

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Many studies have investigated the relationship between medically assisted reproduction (MAR) and health outcomes, particularly cancer, in the offspring. This meta-analysis investigated the association between MAR and childhood cancer. Data sources were PubMed, Scopus, and Web of Science up until June 2018. From the selected studies, we extracted the cancer risk estimates of the exposure of interest (MAR, assisted reproductive technology—ART, and in fitro fertilization—IVF). We conducted the meta-analysis using a random effects model. The outcomes of interest were childhood cancers, classified according to the international classification of childhood cancer (ICCC-3). In our meta-analysis (18 cohort and 15 case-control studies) the overall cancer risk was significantly increased in children conceived by MAR, ART, or IVF. MAR and ART significantly increased the risk for hematological tumors, hepatic tumors, and sarcomas (odds ratio (OR) 1.54; 95% CI 1.18–2.02 and OR 1.92; 95% CI 1.34–2.74, respectively). MAR increased acute myeloid leukemia risk (OR 1.41; 95% CI 1.02–1.95) and ART increased neural cancer risk (OR 1.21; 95% CI 1.01–1.46). Our results suggest an increased risk of cancer in children conceived by MAR. Further studies are needed to investigate the impact of fertility treatments, parental subfertility status, and their association on health outcomes in the offspring.

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Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis

Cited by 136 publications

References 74 publications

Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Cancer Risk in Children and Young Adults (Offspring) Born after Medically Assisted Reproduction: A Systematic Review and Meta-Analysis

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