Worms on the spectrum - C. elegans models in autism research

Schmeißer, Kathrin; Parker, J. Alex

doi:10.1016/j.expneurol.2017.04.007

Cited by 17 publications

(4 citation statements)

References 161 publications

(141 reference statements)

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“…Since Sydney Brenner's Nobel Prize-winning studies, using C. elegans to investigate development and function of nervous system (Brenner, 1973), the nematode contributed greatly to understanding brain physiology. For instance, worms played a great role in determining the role of synaptic proteins such as neuroligin and neurexin in ASD (Schmeisser and Parker, 2017) and used in studies of neurodegenerative diseases, like Alzheimer 's disease (AD) and Parkinson's disease (PD), shedding light on their causes and progression (Calahorro and Ruiz-Rubio, 2011).…”

Section: C Elegans In Neurosciencementioning

confidence: 99%

C. elegans as a model in developmental neurotoxicology

Ruszkiewicz

Pinkas

Miah

et al. 2018

Toxicology and Applied Pharmacology

102

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Due to many advantages Caenorhabditis elegans (C. elegans) has become a preferred model of choice in many fields, including neurodevelopmental toxicity studies. This review discusses the benefits of using C. elegans as an alternative to mammalian systems and gives examples of the uses of the nematode in evaluating the effects of major known neurodevelopmental toxins, including manganese, mercury, lead, fluoride, arsenic and organophosphorus pesticides. Reviewed data indicates numerous similarities with mammals in response to these toxins. Thus, C. elegans studies have the potential to predict possible effects of developmental neurotoxicants in higher animals, and may be used to identify new molecular pathways behind neurodevelopmental disruptions, as well as new toxicants.

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Section: C Elegans In Neurosciencementioning

confidence: 99%

C. elegans as a model in developmental neurotoxicology

Ruszkiewicz

Pinkas

Miah

et al. 2018

Toxicology and Applied Pharmacology

102

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show abstract

“…In the future, discovering novel and effective natural candidates that extend lifespan and that delay aging and related diseases still depends on advancements in state-of-the-art high-throughput screening techniques [ 145 , 146 ]. Combining this effort with studies in suitable model organisms such as C. elegans [ 147 , 148 ] will provide a better platform for understanding the aging process as well as facilitating healthy aging to improve the quality of life of the elderly population.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

et al. 2021

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In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality based on their broad potentials as antioxidant, anti-microbial, anti-carcinogenic, anti-inflammatory, neuroprotective, and anti-aging effects, amongst others. For the past decade and half, efforts to discover bioactive phytochemicals both in pure and crude forms have been intensified using the Caenorhabditis elegans aging model, in which various metabolic pathways in humans are highly conserved. In this review, we summarized the aging and longevity pathways that are common to C. elegans and humans and collated some of the bioactive phytochemicals with health benefits and lifespan extending effects that have been studied in C. elegans. This simple animal model is not only a perfect system for discovering bioactive compounds but is also a research shortcut for elucidating the amelioration mechanisms of aging risk factors and associated diseases.

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“…Thus, the use of the nematode Caenorhabditis elegans (C. elegans), a widely applied model in neurological studies [17,18,19,20,21], and represents an alternative to corroborate studies with humans. Recent contributions have used C. elegans model in the study of axonal regeneration [22], autism [23], neuro-intestinal ferritin regulation [24], Alzheimer's gene expression and neuronal apoptosis [25], and in neural plasticity [26]. Some of the advantages of working with the model are fast reproduction rate, easy maintenance in the laboratory, a small nervous system, and, mainly, the entire genome sequenced [17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

Systematic Characterization of LSD metabolites inC. elegansby ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry

Silveira,

dos Santos,

Ornelas

et al. 2023

Preprint

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Psychedelic compounds have gained renewed interest for their potential therapeutic applications, but their metabolism and effects on complex biological systems remain poorly understood. Here, we present a systematic characterization of LSD metabolites in the model organismCaenorhabditis elegansusing state-of-the-art analytical techniques. By employing ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), we identified and quantified a range of LSD metabolites, shedding light on their metabolic pathways and offering insights into their pharmacokinetics. Our study demonstrates the suitability ofC. elegansas a valuable model system for investigating the metabolism of psychedelic compounds and provides a foundation for further research on the therapeutic potential of LSD. These findings contribute to the growing body of knowledge in the field and highlight the importance of advanced analytical methodologies in elucidating the effects of psychedelic substances on biological systems.

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Worms on the spectrum - C. elegans models in autism research

Cited by 17 publications

References 161 publications

C. elegans as a model in developmental neurotoxicology

C. elegans as a model in developmental neurotoxicology

Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

Systematic Characterization of LSD metabolites inC. elegansby ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry

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