Wortmannin and Wortmannine Analogues from an Undescribed <i>Niesslia</i> sp.

Dischler, Nicole M.; Xu, Luping; Li, Yan; Nichols, Connie B.; Alspaugh, J. Andrew; Bills, Gerald F.; Gloer, James B.

doi:10.1021/acs.jnatprod.8b00923

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Cutaneotrichosporon was negatively associated with Fusarium oxysporum , and could inhibit the infection of Fusarium oxysporum ( Zhu et al, 2022 ). Notably, manure application also enriched coprophilous fungi such as Niesslia , Cephaliophora , Microascus and Chaetomiaceae ( Dischler et al, 2019 ; Zhang X. et al, 2021 ). Due to the lack of sufficient culture studies for some differential species, it was difficult to estimate the ecological impact brought about by the changes in their relative abundance.…”

Section: Discussionmentioning

confidence: 99%

Short-term application of chicken manure under different nitrogen rates alters structure and co-occurrence pattern but not diversity of soil microbial community in wheat field

et al. 2022

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Manure application is an effective way to improve the utilization efficiency of organic resources and alleviate the adverse effects of long-term application of chemical fertilizers. However, the impact of applying manure under different nitrogen rates on soil microbial community in wheat field remains unclear. Treatments with and without chicken manure application under three nitrogen rates (N 135, 180 and 225 kg⋅hm–2) were set in wheat field. Soil organic carbon, available nutrients, and abundance, diversity, structure and co-occurrence pattern of soil microbial community at wheat maturity were investigated. Compared with no manure application, chicken manure application increased the soil organic carbon and available phosphorus, while the effects on soil mineral nitrogen and available potassium varied with different nitrogen rates. Chicken manure application significantly increased soil bacterial abundance under the nitrogen fertilization of 135 and 225 kg⋅hm–2, increased soil fungal abundance under the nitrogen fertilization of 135 kg⋅hm–2, but decreased soil fungal abundance under the nitrogen fertilization of 180 and 225 kg⋅hm–2 (P < 0.05). There was no significant difference in alpha diversity indices of soil microbial communities between treatments with and without chicken manure application under different nitrogen rates (P > 0.05). Chicken manure application and its interaction with nitrogen rate significantly changed soil bacterial and fungal community structures (P < 0.05). There were significantly different taxa of soil microbial communities between treatments with and without chicken manure application. Chicken manure application reduced the ecological network complexity of soil bacterial community and increased that of soil fungal community. In summary, the responses of soil available nutrients and microbial abundance to applying chicken manure varied with different nitrogen rates. One growing season application of chicken manure was sufficient to alter the soil microbial community structure, composition and co-occurrence pattern, whereas not significantly affected soil microbial community diversity.

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Section: Discussionmentioning

confidence: 99%

Short-term application of chicken manure under different nitrogen rates alters structure and co-occurrence pattern but not diversity of soil microbial community in wheat field

et al. 2022

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“…The extract of C. malorum possessed also antifungal activity against phytopathogenic strains, which was attributed to the presence of wortmannin, a known antifungal metabolite, also present in the extract (Additional file 1 : Fig. S8) [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil

Donalle

Martorell

Siless

et al. 2022

Nat. Prod. Bioprospect.

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The Antarctic fungus Cadophora malorum produces previously undescribed cyclic heptapeptides (cadophorin A and B) containing an anthranilic acid residue. The planar structure of these peptides was determined by high-resolution mass spectrometry combined with extensive 1D and 2D NMR spectroscopy. The absolute configuration of the amino acids was determined by Marfey’s method, with HPLC analysis of FDVA (Nα-(2,4-dinitro-5-fluorphenyl)-l-valinamide) derivatives making use of a PFP column. Remarkably, cadophorin 2 possesses both the uncommon d-Ile and d-allo-Ile in its structure. The peptides have metal binding properties as shown by LCMS with post column addition of metal salt solutions. These results were supported by DFT calculations. Graphical Abstract

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“…In specific cases, autophagy inhibition [187][188][189] Based on their blocking effect on class III PI3K activity, the natural product wortmannin [46,47] and its concurrent synthetic compounds, 3-methyladenine (3-MA), KU55933 and LY294002, are well recognized as early stage autophagy inhibitors in the literature [190]. Wortmannin was originally identified as a potent inhibitor of the neutrophil respiratory burst and smooth muscle myosin light chain kinase (MLCK) [48].…”

Section: Approved For Cancersmentioning

confidence: 99%

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer

Al-Bari

Ito

Ahmed

et al. 2021

IJMS

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Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic interventions in various diseases, including cancers. According to the framework of autophagy, the suppression or induction of autophagy can exert therapeutic properties through the promotion of cell death or cell survival, which are the two main events targeted by cancer therapies. Remarkably, natural products have attracted attention in the anticancer drug discovery field, because they are biologically friendly and have potential therapeutic effects. In this review, we summarize the up-to-date knowledge regarding natural products that can modulate autophagy in various cancers. These findings will provide a new position to exploit more natural compounds as potential novel anticancer drugs and will lead to a better understanding of molecular pathways by targeting the various autophagy stages of upcoming cancer therapeutics.

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Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Cited by 8 publications

References 22 publications

Short-term application of chicken manure under different nitrogen rates alters structure and co-occurrence pattern but not diversity of soil microbial community in wheat field

Short-term application of chicken manure under different nitrogen rates alters structure and co-occurrence pattern but not diversity of soil microbial community in wheat field

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer

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