Would Phoenix Dactyflera Pollen (palm seed) be considered as a treatment agent against Males’ infertility? A systematic review

Abstract

IntroductionOxidative stress is a key factor involved in male infertility, which is due to an unnatural increase in environmental free radicals. In the majority of cases, this has a negative effect on a male’s ability to impregnate a female. Currently, it is believed that spermatozoa can be protected against the damages induced by oxidative stress by saturating sperm with antioxidants. The antioxidant role of phoenix dactylifera pollen is capable of collecting the reactive oxygen and neutralizing it in and out of body cells. The present research provides a review of the antioxidant roles of phoenix dactylifera pollen on male infertility.MethodsThis research is based on English-Language studies and articles found by comprehensively reviewing electronic databases, websites, books, and academic articles over the last 10 years.ResultsThe phenolic compounds of phoenix dactylifera pollen, due to the existing polyphenols, are strong chelators of heavy metals. Therefore, they are effective in eliminating environmental hydroxyl radicals. Moreover, these plants have high capacities of eliminating hydroxyl free radicals, picrylhydrazyl, diphenyl and phoenix dactylifera pollen and also inhibiting glutathione-S-transferase (GST).ConclusionCurrently, the use of herbal antioxidants to neutralize reactive oxygen species (ROS) and reduce the negative effects of oxidative stress on body cells and tissues has attracted researchers’ attention. Various substances, such as flavonoids and catechins, perform their antioxidant role by increasing the concentration of glutathione peroxidase. The final product of this process is an increase in the number of motile sperm, which can have significant effects on fertility.

Improvement of Semen Parameters in a Man With Idiopathic Severe Oligoasthenoteratozoospermia Using Date Palm Pollen (Phoenix dactylifera L.) Based on Iranian Traditional Medicine: A Case Report and Literature Preview

“…Arginine, one of the main amino acids in the drug (9), acts as an antioxidant in the empirical treatment of idiopathic male infertility (4). A systematic review has highlighted its effects on improving semen parameters caused by the impact on the antioxidant system (18).…”

Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

“…Hepatotoxicity induced by various chemicals was reversed by Phoenix dactylifera [18,19]. It is also found to be effective in diabetes [20], male infertility (seeds) [21,22], inflammation, and bacterial infection [23]. Moreover, cardioprotective [24] and antioxidant actions [25] are also reported widely.…”

Impact of Algerian date palm pollen aqueous extract on epididymal and ejaculated rabbit sperm motility duringin vitroincubation

“…Additionally, various in vitro and in vivo experimental studies, and clinical trials, have evaluated the effects of DPP on the reproductive system. All research indicates that there are significant improvements in the sperm parameters, such as motility, viability, acrosome reaction, and lipid peroxidation (Fallahi et al 2015). Al-Samarrai et al (2017) have found a higher fertility on rabbit bucks after orally administration of DPP suspension, which enhance the production of testosterone and increase the spermatogenesis.…”

“…DPP is known to contain a variety of compounds such as a high concentration of total phenolic content, flavonoids and anthocyanins as well as the presence of significant quantity of selenoproteins (Baliga et al 2011) which makes it an excellent candidate for antioxidant activity associated to low negative side effects (Fallahi et al 2015). Thus it is a very suitable supplement in infertility particularly by reducing free radicals and enhancing sperm motility (Fallahi et al 2015). Therefore, synergic beneficial effect of bioactive compounds along with antioxidant activity of DPP extract might result to improved properties of spermatozoa.…”