Would Women Trust Their Partners to Use a Male Pill?

Glasier, Anna; Anakwe, Raymond; Everington, Dawn; Martin, Cécile; Spuy, Z. Van der; Cheng, L.; Ho, PC; Anderson, Ronald D.

doi:10.1097/00006254-200008000-00022

Cited by 28 publications

(41 citation statements)

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“…Several reports have highlighted that men would be willing to be actively involved in family planning and use chemical contraceptives [119,120]. Besides, women in stable relationships have also been reported to be willing to rely in their partner to use a contraceptive [121]. Nevertheless, the development of a reversible and safe male chemical contraceptive has been a very difficult task.…”

Section: Male Contraception At a Glancementioning

confidence: 99%

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Alves¹,

Dias²,

Silva³

et al. 2015

CMP

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Abstract:The development of a "male pill" to control fertility is still a major challenge. Although women have several options to play an active role in the couple family planning, men are very limited in terms of contraceptive methods. Several approaches have been proposed to develop a male contraceptive and can be divided in two major groups: hormonal and non-hormonal methods. Within the testis, the somatic Sertoli cell (SC) is known as the "nurse cell" since it provides the physical and nutritional support for the developing germ cells. Moreover, adjacent SCs form the Sertoli/blood testis barrier (BTB), which divides the seminiferous epithelium into the basal and the apical compartments, controlling the passage of substances to the site where germ cells develop. Among the several functions of SC, its metabolism and the production of lactate, acetate and other metabolic factors are essential for the normal occurrence of spermatogenesis. In the last years, several works have highlighted that the metabolic cooperation established between SCs and developing germ cells is compromised in several diseases associated with male subfertility/infertility. Notably, several metabolismassociated proteins are specifically expressed in the testis. Thus, there are several evidences illustrating that the control of male fertility can be achieved by targeting testicular cells metabolism. Herein, we discuss the metabolic cooperation in testis as a potential pharmacological target to counteract subfertility/infertility promoted by several diseases, particularly metabolic diseases. We also discuss how it can contribute to the development of a male contraceptive.

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Section: Male Contraception At a Glancementioning

confidence: 99%

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Alves¹,

Dias²,

Silva³

et al. 2015

CMP

View full text Add to dashboard Cite

show abstract

“…22 In a cross-cultural survey of 1829 white, colored, black, East Asian and other men in Edinburgh, United Kingdom; Cape Town, South Africa; Shanghai and Hong Kong, China, supported by the UK government, the majority welcomed a new male hormonal method and 44-83% stated that they would use an oral form of male hormonal contraception. 23 There were significant differences in perceived contraceptive efficacy, convenience, and change in sexual satisfaction and masculinity among the different ethnic groups.…”

Section: Ethnic Differences In Acceptability Of Male Contraceptive Mementioning

confidence: 99%

“…Chinese women were most concerned about side effects and associated health risks compared to women from Edinburgh or Cape Town where the concern was mostly lack of trust. 22 In a survey of more than 9000 men from nine countries on four continents including Europe, North America, Central/South America and East Asia, 55% of men interviewed reported willingness to use male hormonal method ranging from 28.5% in Indonesia as a representative of East Asian population to 71.4% in Spain. The oral route was the most preferred method compared to monthly injections or annual implants in all participating countries except in Indonesia where monthly injection and oral pills was equally desirable.…”

Section: Ethnic Differences In Acceptability Of Male Contraceptive Mementioning

confidence: 99%

Does ethnicity matter in male hormonal contraceptive efficacy?

Ilani¹,

Liu²,

Swerdloff³

et al. 2011

Asian J Androl

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The development of male hormonal contraception has progressed significantly during the last three decades. The ultimate goal is to produce an effective, safe and reversible male method of contraception that are within reach of and can be used by all men globally. This review aims to outline the recent developments in male hormonal contraception with special emphasis on how ethnicity influences acceptability, extent of sperm suppression, and rate of recovery of spermatogenesis. Baseline differences in testicular histomorphology and testosterone metabolism between East Asian and Caucasian men have been reported, but whether this contributes significantly to varying degrees of sperm suppression in response to exogenous testosterone therapy is less known. Testosterone alone male hormonal contraceptive regimens are effective and applicable for East Asian men, and less so for Caucasians. Combinations of progestins with androgens are sufficient to optimize effectiveness of suppression and applicability to all ethnicities. New compounds such as steroidal or non-steroidal selective androgen receptor modulators with dual androgenic and progestational activities are potential compounds for further development as male hormonal contraceptive methods. At the present time, combined androgen and progestin contraceptive regimens appear to be effective, safe, reversible and convenient to use for all men with ethnic, cultural and environmental differences. Further refinements on the hormonal agent, methods of delivery, and dose optimization of the androgen relative to the progestin are necessary. This goal mandates further investment and large clinical trials in multiethnic populations to better define safety and efficacy.

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“…Sperm counts return to normal after the cessation of T administration. In surveys, both men and women in a variety of countries indicate that such a male contraceptive would be useful and appealing [21,22].…”

Section: Male Hormonal Contraceptive Developmentmentioning

confidence: 99%

Regulation of testicular function in men: implications for male hormonal contraceptive development

Amory

Bremner

2003

The Journal of Steroid Biochemistry and Molecular Biology

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In the adult male, the testes produce both sperm and testosterone. The function of the testicles is directed by the central nervous system and pituitary gland. Precise regulation of testicular function is conferred by an elegant feedback loop in which the secretion of pituitary gonadotropins is stimulated by gonadotropin hormone-releasing hormone (GnRH) from the hypothalamus and modulated by testicular hormones. Testosterone and its metabolites estradiol and dihydrotestosterone (DHT) as well as inhibin B inhibit the secretion of the gonadotropins both directly at the pituitary and centrally at the level of the hypothalamus. In the testes, LH stimulates testosterone synthesis and FSH promotes spermatogenesis, but the exact details of gonadotropin action are incompletely understood. A primary goal of research into understanding the hormonal regulation of testicular function is the development of reversible, safe and effective male hormonal contraceptives. The administration of exogenous testosterone suppresses pituitary gonadotropins and hence spermatogenesis in most, but not all, men. The addition of a second agent such as a progestin or a GnRH antagonist yields more complete gonadotropin suppression; such combination regimens effectively suppress spermatogenesis in almost all men and may soon bring the promise of hormonal male contraception to fruition.

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Would Women Trust Their Partners to Use a Male Pill?

Cited by 28 publications

References 0 publications

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Metabolic Cooperation in Testis as a Pharmacological Target: From Disease to Contraception

Does ethnicity matter in male hormonal contraceptive efficacy?

Regulation of testicular function in men: implications for male hormonal contraceptive development

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