Individuals usually benefit from Pokémon Go gaming because this mobile video game provides an attractive opportunity for increased outdoor physical activity and socializing. However, based on prior studies on gaming and electronic media use, excessive Pokémon Go involvement is likely to be related to adverse phenomena such as mental problems (smartphone addiction and phubbing), pain (in neck, arms, and legs), and eye-related problems (dry eye and impaired focusing). We expected that excessive Pokémon Go players would exhibit stronger mental and physical symptomatology. Pokémon Go players (N = 450) completed an online survey reporting Pokémon Go addiction symptoms, smartphone addiction symptoms, phubbing habits, time spent playing Pokémon Go, pain, and eye problems. We also controlled for overall use of other electronic media. We found that individuals with higher levels of Pokémon Go addiction reported more pain and more problems with vision. Increased smartphone addiction and phubbing partially mediated these effects. This study contributes to a balanced perspective on the biopsychosocial outcomes of health behaviors gamification via mobile video games.