Wound Dressing in the Oral Cavity

Sharon, Esi; Polak, David; Sharon, Shay; Beyth, Nurit

doi:10.1007/15695_2017_5

Cited by 2 publications

(1 citation statement)

References 70 publications

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“…The mucus layer is also very dynamic, with a mucus turnover rate that ranges from seconds on ocular surfaces to hours in the digestive tracts, removing foreign objects in the process. To address these challenges, many transmucosal drug delivery systems, , mucosal wound dressings, and mucosal tissue engineering scaffolds, , have been engineered to adhere to mucosal surfaces to increase their residency times.…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Mucoadhesive Spider Silk

et al. 2018

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Mucoadhesion is defined as the adhesion of a material to the mucus gel covering the mucous membranes. The mechanisms controlling mucoadhesion include nonspecific electrostatic interactions and specific interactions between the materials and the mucins, the heavily glycosylated proteins that form the mucus gel. Mucoadhesive materials can be used to develop mucosal wound dressings and noninvasive transmucosal drug delivery systems. Spider silk, which is strong, biocompatible, biodegradable, nontoxic, and lightweight would serve as an excellent base for the development of such materials. Here, we investigated two variants of the partial spider silk protein 4RepCT genetically engineered in order to functionalize them with mucoadhesive properties. The pLys-4RepCT variant was functionalized with six cationically charged lysines, aiming to provide nonspecific adhesion from electrostatic interactions with the anionically charged mucins, while the hGal3-4RepCT variant was genetically fused with the Human Galectin-3 Carbohydrate Recognition Domain which specifically binds the mucin glycans Galβ1-3GlcNAc and Galβ1-4GlcNAc. First, we demonstrated that coatings, fibers, meshes, and foams can be readily made from both silk variants. Measured by the adsorption of both bovine submaxillary mucin and pig gastric mucin, the newly produced silk materials showed enhanced mucin binding properties compared with materials of wild-type (4RepCT) silk. Moreover, we showed that pLys-4RepCT silk coatings bind mucins through electrostatic interactions, while hGal3-4RepCT silk coatings bind mucins through specific glycan-protein interactions. We envision that the two new mucoadhesive silk variants pLys-4RepCT and hGal3-4RepCT, alone or combined with other biofunctional silk proteins, constitute useful new building blocks for a range of silk protein-based materials for mucosal treatments.

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Section: Introductionmentioning

confidence: 99%

Genetically Engineered Mucoadhesive Spider Silk

et al. 2018

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Clinical Efficacy of Various Oral Wound Dressing Materials; A Systematic Review

Ahmed¹,

Yaqub²,

Almalik³

et al. 2022

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For wounds, discomfort, infection, and healing, there are a limited number of medications used in oral and maxillofacial surgery. Despite their widespread use, little is known about these medications' components, applications, and effects on oral tissues. Whitehead's varnish (WV), Carnoy's solution (CS), Bismuth Iodoform Paraffin paste (BIPP), Zinc Oxide Eugenol (ZOE), Alvogyl are some of the substances that can be used effectively. A systematic literature review from 2012 to 2022 will be performed using databases such as PubMed, Medline, and Sciencedirect. The keywords used will be "BIPP", "ZOE", "Alvogyl" and "intraoral wound dressing". PRISMA flowchart will be used to describe the selection process of searched articles. Mixed findings have been observed especially when choosing between ZOE and Alvogyl as an intraoral wound dressing material. Each of these two materials possesses suitable qualities. However, BIPP has not been witnessed to be used frequently due to its potential for side effects when used for longer durations. Alvogyl and Zinc Oxide Eugenol are equally acceptable materials of choice for use as intraoral dressing.

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Wound Dressing in the Oral Cavity

Cited by 2 publications

References 70 publications

Genetically Engineered Mucoadhesive Spider Silk

Genetically Engineered Mucoadhesive Spider Silk

Clinical Efficacy of Various Oral Wound Dressing Materials; A Systematic Review

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