Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites

Naseri-Nosar, Mahdi; Ziora, Zyta M.

doi:10.1016/j.carbpol.2018.02.003

Cited by 279 publications

(120 citation statements)

References 182 publications

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“…According to the degree of ionization of glucosamine groups of chitosan, the antimicrobial and adsorption properties can be altered by variable pH levels [8][9][10][11]. Diverse applications of chitosan have been found in many fields that exploit its pH-dependent binding properties, as evidenced in wastewater treatment, food preservation and biomedical devices [8,9,[12][13][14][15][16][17][18]. To attain additional performance in these applications, research has also focused on the design of different morphological forms of chitosan that include nanofibrous systems, owing to the high surface area of these biomaterials [2][3][4]14,[16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

A Spectroscopic Study of Solid-Phase Chitosan/Cyclodextrin-Based Electrospun Fibers

Chen

Wilson

2019

Fibers

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In this study, chitosan (chi)/hydroxypropyl-β-cyclodextrin (HPCD) 2:20 and 2:50 Chi:HPCD fibers were assembled via an electrospinning process that contained a mixture of chitosan and HPCD with trifluoroacetic acid (TFA) as a solvent. Complementary thermal analysis (thermal gravimetric analysis (TGA)/differential scanning calorimetry (DSC)) and spectroscopic methods (Raman/IR/NMR) were used to evaluate the structure and composition of the fiber assemblies. This study highlights the multifunctional role of TFA as a solvent, proton donor and electrostatically bound pendant group to chitosan, where the formation of a ternary complex occurs via supramolecular host–guest interactions. This work contributes further insight on the formation and stability of such ternary (chitosan + HPCD + solvent) electrospun fibers and their potential utility as “smart” fiber coatings for advanced applications.

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Section: Introductionmentioning

confidence: 99%

A Spectroscopic Study of Solid-Phase Chitosan/Cyclodextrin-Based Electrospun Fibers

Chen

Wilson

2019

Fibers

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“…Therefore, there is a need to develop a wound dressing that can prolong the residence time of the antibiotics in the infected wound, absorb exudate, and maintain a moist environment around the wound area [15].Modern wound dressings (film wafers, hydrogels, and sponges) are designed to overcome the limitations of conventional wound dressings. The design and application of these dressings has been comprehensively reviewed [2,16], where it has been emphasized that the dressing materials must be biocompatible, exudate absorbing, allow water vapor transmission (WVTR), and possess antibacterial properties [16,17]. A simple method of preparation, excellent WVTR, transparency, and cost effectiveness are the attributes of good film dressings [18,19].Numerous synthetic and natural polymers and combinations thereof have been explored for making film dressings.…”

mentioning

confidence: 99%

“…Among the natural polymers chitosan, gelatin, alginate, pectin, and cellulose have shown promise for this purpose [12,13,15,[20][21][22]. However, insufficient mechanical strength, stability, poor exudate-absorbing capacity, and adherence with wound site are the major limitations associated with natural polymer-based films [16]. In order to overcome these limitations, there is a need to explore more biopolymers for such applications.…”

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confidence: 99%

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

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“…This result could be explained by the particle's agglomeration in the matrix. Currently, advanced approaches to wound healing have attracted great attention for the use of novel types of dressing that provide a moist environment to the wound area [74]. This property encourages fast and effective healing, which is particularly important when dealing with chronic wounds [8,23].…”

Section: Effect Of Different Mmt Concentrations On Bc Propertiesmentioning

confidence: 99%

Evaluation of Different Methods for Cultivating Gluconacetobacter hansenii for Bacterial Cellulose and Montmorillonite Biocomposite Production: Wound-Dressing Applications

et al. 2020

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Bacterial cellulose (BC) has received considerable attention due to its unique properties, including an ultrafine network structure with high purity, mechanical strength, inherent biodegradability, biocompatibility, high water-holding capacity and high crystallinity. These properties allow BC to be used in biomedical and industrial applications, such as medical product. This research investigated the production of BC by Gluconacetobacter hansenii ATCC 23769 using different carbon sources (glucose, mannitol, sucrose and xylose) at two different concentrations (25 and 50 g∙L−1). The BC produced was used to develop a biocomposite with montmorillonite (MMT), a clay mineral that possesses interesting characteristics for enhancing BC physical-chemical properties, at 0.5, 1, 2 and 3% concentrations. The resulting biocomposites were characterized in terms of their physical and barrier properties, morphologies, water-uptake capacities, and thermal stabilities. Our results show that bacteria presented higher BC yields in media with higher glucose concentrations (50 g∙L−1) after a 14-day incubation period. Additionally, the incorporation of MMT significantly improved the mechanical and thermal properties of the BC membranes. The degradation temperature of the composites was extended, and a decrease in the water holding capacity (WHC) and an improvement in the water release rate (WRR) were noted. Determining a cost-effective medium for the production of BC and the characterization of the produced composites are extremely important for the biomedical applications of BC, such as in wound dressing materials.

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Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites

Cited by 279 publications

References 182 publications

A Spectroscopic Study of Solid-Phase Chitosan/Cyclodextrin-Based Electrospun Fibers

A Spectroscopic Study of Solid-Phase Chitosan/Cyclodextrin-Based Electrospun Fibers

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

Evaluation of Different Methods for Cultivating Gluconacetobacter hansenii for Bacterial Cellulose and Montmorillonite Biocomposite Production: Wound-Dressing Applications

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