Wound healing ability of acellular fish skin and bovine collagen grafts for split-thickness donor sites in burn patients: Characterization of acellular grafts and clinical application

Yoon, Jaechul; Yoon, Dogeon; Lee, Hyeongjin; Lee, JiUn; Jo, SeoYul; Kym, Dohern; Yim, Haejun; Hur, Jun; Chun, Wook; Kim, GeunHyung; Cho, Yong Suk

doi:10.1016/j.ijbiomac.2022.02.055

Cited by 37 publications

(34 citation statements)

References 29 publications

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“…Current strategies not only aim at improving of burn wound healing and outcome, but also at reducing required split-thickness skin grafting [ 4 ]. If split-thickness skin grafting is performed, AFS might be used as a biocompatible dressing option: Yoon et al investigated the wound healing properties of Kerecis ® Omega3 in split-thickness donor sites of burn patients in comparison to a bovine collagen skin graft (ProHeal ® Collagen Wound Dressing, MedSkin Solutions, Billerbeck, Germany) [ 31 ]. Treatment with Kerecis ® Omega3 demonstrated accelerated wound healing (9.1 ± 1 days) compared to the treatment with ProHeal ® (10.7 ± 1.45 days) or untreated sites by nearly two days [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…If split-thickness skin grafting is performed, AFS might be used as a biocompatible dressing option: Yoon et al investigated the wound healing properties of Kerecis ® Omega3 in split-thickness donor sites of burn patients in comparison to a bovine collagen skin graft (ProHeal ® Collagen Wound Dressing, MedSkin Solutions, Billerbeck, Germany) [ 31 ]. Treatment with Kerecis ® Omega3 demonstrated accelerated wound healing (9.1 ± 1 days) compared to the treatment with ProHeal ® (10.7 ± 1.45 days) or untreated sites by nearly two days [ 31 ]. As suggested in prior studies, wound healing acceleration might be caused due to an increased cell proliferation and a synergistic effect of the biophysical properties of AFS [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Treatment with Kerecis ® Omega3 demonstrated accelerated wound healing (9.1 ± 1 days) compared to the treatment with ProHeal ® (10.7 ± 1.45 days) or untreated sites by nearly two days [ 31 ]. As suggested in prior studies, wound healing acceleration might be caused due to an increased cell proliferation and a synergistic effect of the biophysical properties of AFS [ 31 ]. In a different case series by Alam et al, wound healing of split-thickness donor sites treated with Kerecis ® Omega3 showed an average total reepithelialization time of 11.5 days (range 10–16 days) [ 3 ], whereby longer reepithelialization time is observed in larger donor sites or thicker split-thickness grafts [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…Despite being considered as the current gold standard for early wound closure in deep dermal and full-thickness burn injuries, split-thickness skin grafting may be limited in selected cases [ 31 ]. Current strategies aiming at improvement of burn wound healing and outcome as well as the reduction of necessary split-thickness skin grafting mainly include biological and synthetic skin replacement products [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

et al. 2022

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Background and Objectives: Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development of acellular fish skin. Acellular fish skin acts as a skin substitute, reducing inflammatory responses and advancing proinflammatory cytokines that promote wound healing. Due to these beneficial wound healing properties, acellular fish skin might represent an effective treatment approach in burn wound management. Materials and Methods: A systematic review of the literature, up to March 2022, was conducted using the electronic databases PubMed and Web of Science. Titles and abstracts were screened for the following key terms (variably combined): “fish skin”, “fish skin grafts”, “acellular fish skin”, “Omega3 Wound matrix”, “xenograft”, “burn injury”, “burns”. Results: In total, 14 trials investigating the effects of acellular fish skin in burn wounds or split-thickness donor sites were determined eligible and included in the present review. Existing evidence on the use of acellular fish skin indicates an acceleration of wound healing, reduction in pain and necessary dressing changes as well as treatment-related costs and improved aesthetic and functional outcomes compared to conventional treatment options. Conclusions: Acellular fish skin xenografts may represent an effective, low-cost alternative in treatment of superficial- and partial-thickness burns. However, results mainly originate from preclinical and small cohort studies. Future larger cohort studies are warranted to elucidate the full potential of this promising approach.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

et al. 2022

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“…In the last two decades, the construction of skin tissue engineering from natural-based products with the advent of newer fabrication strategies has shown promise in treating various skin-related disorders, such as burns and deep wounds [ 8 , 9 , 10 ]. Natural-based biomaterials are incorporated into products that can reduce evaporative water loss and exudation of protein-rich fluids, prevent wound drying, and inhibit microbial reproduction [ 11 ]. Worldwide best practice guidelines for treating chronic wounds suggest redressing and applying infection control measures, and these are critical factors in the limited coherent clinical evidence for many approved products for active wound areas.…”

Section: Introductionmentioning

confidence: 99%

The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

et al. 2022

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Current research across the globe still focuses strongly on naturally derived biomaterials in various fields, particularly wound care. There is a need for more effective therapies that will address the physiological deficiencies underlying chronic wound treatment. The use of moist bioactive scaffolds has significantly increased healing rates compared to local and traditional treatments. However, failure to heal or prolonging the wound healing process results in increased financial and social stress imposed on health institutions, caregivers, patients, and their families. The urgent need to identify practical, safe, and cost-effective wound healing scaffolding from nature-based biomaterials that can be introduced into clinical practice is unequivocal. Naturally derived products have long been used in wound healing; however, clinical trial evaluations of these therapies are still in their infancy. Additionally, further well-designed clinical trials are necessary to confirm the efficacy and safety of nature-based biomaterials in treating wounds. Thus, the focus of this review is to describe the current insight, the latest discoveries in selected nature-based wound healing implant products, the possible action mechanisms, and an approach to clinical studies. We explore several tested products undergoing clinical trials as a novel approach to counteract the debilitating effects of impaired wound healing.

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The Use of Acellular Tissue Matrices in Gender‐Affirming Surgery: Review of the Literature and Institutional Experience

Alba,

Weinstein,

Arnold

et al. 2023

Advanced Biology

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Wound healing complications are not uncommon after genital gender‐affirming surgery and can pose significant challenges for the reconstructive surgeon. Acellular tissue matrices are products that contain extracellular matrix compounds without living cells and are used to expedite and improve wound healing. Some of these products have been described for a variety of different indications in gender‐affirming surgery. In this paper, the authors present a review of the current literature on the use of acellular tissue matrices in gender‐affirming surgery as well as the authors’ institutional experience in using these products.

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Wound healing ability of acellular fish skin and bovine collagen grafts for split-thickness donor sites in burn patients: Characterization of acellular grafts and clinical application

Cited by 37 publications

References 29 publications

The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

The Use of Acellular Tissue Matrices in Gender‐Affirming Surgery: Review of the Literature and Institutional Experience

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