Wound Healing Activity of Phage-Sisplayed TGF-β1 Model Peptide in Streptozotocin-Induced Diabetic Rats

Du, Hong; Jiang, Duyin; Song, Guodong; Cao, Chunyan; Zhang, Dong; Yu, Panxi; Lai, Chenzhi; Guo, Xiaoshuang; Zong, Xin; Jin, Xiaolei

doi:10.1007/s10989-020-10152-1

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…TGF-ß is a powerful inflammatory system regulator that appears to have a role in both the onset and resolution of general inflammatory reactions. It increases monocyte motility and growth factor production, but once an inflammatory reaction is initiated, it also displays potent anti-inflammatory effects such as inhibiting neutrophil and T-lymphocyte adherence to endothelium, downregulating macrophages, and antagonizing TNF-α function (6).…”

Section: Discussionmentioning

confidence: 99%

“…Re-epithelialization is a vital stage in the healing process that permits keratinocytes to move over the wound bed and restore epidermal layers (19). TGF-β can facilitate re-epithelialization, promote fibroblast cell migration and proliferation, improve myofibroblast function, and involve in wound healing improvement (6).…”

Section: Discussionmentioning

confidence: 99%

“…Wound epithelization is an important part of effective healing that is organized by a complicated interaction between keratinocytes and the underlying stroma that involves many growth factors, including TGF-β (5). The sufficient synthesis of TGF-β is essential for wound healing and other biological processes, and a decreased level in the wound tissue has been linked to a slower healing process (6). This study focused on the effect of topical nifedipine ointment 1% and 2% on serum levels of TGF-β during facial skin wound healing in rabbits.…”

Section: Introductionmentioning

confidence: 99%

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EFFECTS OF FORMULATED TOPICAL NIFEDIPINE OINTMENT ON TGF-β AND ACCELERATION OF FACIAL SKIN WOUND HEALING IN RABBITS

Al-Dabbagh¹,

Al-Mashhadane²,

Al-Sarraj³

2023

Mil. Med. Sci. Lett.

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The purpose of this study was to evaluate the impact of 1% and 2% topical nifedipine ointments on TGF-β and the acceleration of facial skin wound healing in rabbits. Nifedipine ointments of 1% and 2% were prepared. Fifty healthy male rabbits were involved and distributed into two groups according to the study period: group A (7 days) and group B (14 days). Each group was subdivided into five groups (5 rabbits/group): Group I (Normal): rabbits did not undergo a surgical procedure and did not receive treatment; group II (negative control): rabbits had surgical wounds without treatment; group III (positive control): rabbits had surgical wounds with white petroleum treatment; group IV(nifedipine 1%): rabbits had surgical wounds with nifedipine 1% ointment treatment; and group V(nifedipine 2%): rabbits had surgical wounds with nifedipine 2% ointment treatment. Following euthanasia, blood samples (5 ml) were collected from all animals for TGF-β analysis using an ELISA kit. The TGF-β level in NFD 1% group was significantly higher on the 7 th and14 th day of the study associated with a higher rate of wound closure in comparison to other groups. Conclusions: Nifedipine 1% ointment has beneficial value for improving wound healing, while nifedipine NFD 2% has no such effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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EFFECTS OF FORMULATED TOPICAL NIFEDIPINE OINTMENT ON TGF-β AND ACCELERATION OF FACIAL SKIN WOUND HEALING IN RABBITS

Al-Dabbagh¹,

Al-Mashhadane²,

Al-Sarraj³

2023

Mil. Med. Sci. Lett.

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“…1,2 In recent years, the incidence rate of diabetes has increased significantly, affecting the health of about 425 million people around the world. 2 Diabetic foot ulcer (DFU), also known as diabetic extremity gangrene, is a serious chronic complication of diabetes and also a significant cause of disability and death in diabetic patients. 3 DFU is caused by peripheral neuropathy, lower extremity arterial insufficiency, bacterial infection, and other factors in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

“…Diabetes is now a global epidemic disease, and the number of patients is increasing every year. , In recent years, the incidence rate of diabetes has increased significantly, affecting the health of about 425 million people around the world . Diabetic foot ulcer (DFU), also known as diabetic extremity gangrene, is a serious chronic complication of diabetes and also a significant cause of disability and death in diabetic patients .…”

Section: Introductionmentioning

confidence: 99%

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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The emergence of peroxidase (POD)-like nanozyme-derived catalytic therapy has provided a promising choice for reactive oxygen species (ROS)-mediated broad-spectrum antibacterials to replace antibiotics, but it still suffers from limitations of low therapeutic efficiency and unusual addition of unstable H2O2. Considering that the higher blood glucose in diabetic wounds provides much more numerous nutrients for bacterial growth, a cascade nanoenzymatic active material was developed by coating glucose oxidase (GOx) onto POD-like Fe2(MoO4)3 [Fe2(MoO4)3@GOx]. GOx could consume the nutrient of glucose to produce gluconic acid (weakly acidic) and H2O2, which could be subsequently converted into highly oxidative •OH via the catalysis of POD-like Fe2(MoO4)3. Accordingly, the synergistic effect of starvation and ROS-mediated therapy showed significantly efficient antibacterial effect while avoiding the external addition of H2O2 that affects the stability and efficacy of the therapy system. Compared with the bactericidal rates of 46.2–59.404% of GOx or Fe2(MoO4)3 alone on extended-spectrum β-lactamases producing Escherichia coli and methicillin-resistant Staphylococcus aureus, those of the Fe2(MoO4)3@GOx group are 98.396 and 98.776%, respectively. Animal experiments showed that the as-synthesized Fe2(MoO4)3@GOx could much efficiently promote the recovery of infected wounds in type 2 diabetic mice while showing low cytotoxicity in vivo.

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Amelioration of full-thickness cutaneous wound healing using stem cell exosome and zinc oxide nanoparticles in rats

Salem,

Ateya,

Shouman

et al. 2024

Heliyon

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Wound Healing Activity of Phage-Sisplayed TGF-β1 Model Peptide in Streptozotocin-Induced Diabetic Rats

Cited by 4 publications

References 35 publications

EFFECTS OF FORMULATED TOPICAL NIFEDIPINE OINTMENT ON TGF-β AND ACCELERATION OF FACIAL SKIN WOUND HEALING IN RABBITS

EFFECTS OF FORMULATED TOPICAL NIFEDIPINE OINTMENT ON TGF-β AND ACCELERATION OF FACIAL SKIN WOUND HEALING IN RABBITS

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Amelioration of full-thickness cutaneous wound healing using stem cell exosome and zinc oxide nanoparticles in rats

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