Wound healing activity of the ethanol root extract and polyphenolic rich fraction from<i>Potentilla fulgens</i>

Anindita, Kundu; Ghosh, Arka; Singh, Neeti Rajan; Singh, Gireesh Kumar; Seth, Ankit; Maurya, Sudarshan; Hemalatha, S; Laloo, Damiki

doi:10.3109/13880209.2016.1157192

Cited by 39 publications

(12 citation statements)

References 33 publications

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“…Among these, the applications of plant based nanotechnology plays a significant role in the process of wound healing [16,17]. The plant based materials have proved at all times to be a powerful remedy for health care [18][19][20][21][22][23][24][25][26][27]. Accordingly, the grape seed extract containing PCs have been investigated for wound treatment and in the management of many illnesses such as cancers, cardiovascular disease, gastric ulcers, obesity and skin inflammations.…”

Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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Proanthocyanidins (PCs), a component of grape seed extract (GSE), has recently being used for the treatment of wounds. However, poor absorption, poor stability and rapid elimination from the systemic circulation limit its acceptance. In addressing these problems, we herein report the development of PCs based nanoformulations (PCs/SOLU) for the first time based on 1 % GSE and assessed its wound healing potential in-vivo on the wistar rats. GSE and PCs/SOLU nanodispersions 1 % were prepared by incorporating them into the ointment base via uniform mixing to form ointment which could be easily applied topically to wounds. The antibacterial activity of PCs/SOLU against gram positive and gram-negative bacteria strains proved that the cell membranes became more permeable with disrupted cell structure. While carrageenan and histamine induced rat paw edema analyses show there was no inflammatory signs in animals treated with 1 wt% of PCs/SOLU nanodispersion. Excision wound measuring about 3 cm in depth was created on the wistar rats. The ointment was applied topically on the wounded site and the wound contraction was measured daily. Grape seed extract (GSE) ointment, ointment base and povidone-iodine (Povi-Iod) ointment of about 1 % was used as the control, positive and negative standards. PCs/SOLU nanodispersion heals the wound by mobilising the fibroblasts in the wound site and inhibits the inflammatory response through decreased expression of monocyte. The macroscopical, immunological and histopathological assessments revealed that PCs/SOLU nanodispersion ointment usage improves the cell adhesion and proliferation

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Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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“…The 30 rats were separated into three groups as a control group, SCI group and SCI + P. fulgens treated group (400 mg/ /kg/day, i.p.) [24].…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis

2015

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Background: This examination was performed to research the advantage of the antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats. Materials and methods: In the SCI model of this examination, the tolerably serious lesion was performed at the L1-L2 spinal segmental level. SCI animals were given P. fulgens 400 mg/kg/day, intraperitoneally. At 7 days post-lesion, exploratory rats were executed after intraperitoneal administration 7 ketamine HCL (0.15 mL/100 g body weight). Spinal cord specimens were taken for histological examination or assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content, trailed by noteworthy increments in MDA levels and MPO action. Results: Degenerative changes in some multipolar and bipolar nerve cells and pyknotic changes in the nuclei of glial cells were likewise noticed. Remarkable development was seen in cells and vascular structures of P. fulgens treated groups when contrasted with untreated groups. Conclusions: Potentilla fulgens application may influence angiogenetic improvement in vein endothelial cells, reduce inflammatory cell aggregation by influencing cytokine system and may make apoptotic nerve cells and neuroprotective component in glial cells.

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“…Wound healing is a complex process in which the skins, and the tissues under it, repair themselves after injury (2). he wound healing process is divided into three phases as inflammation (0-3 days), cellular proliferation (3-12 days) and tissue remodelling (3-6 months) (3,4). During inflammatory phase, it involves the recruitment of leukocytes (neutrophils and macrophages) at the site of injury.…”

Section: Introductionmentioning

confidence: 99%

Reinwardtia indica: phytochemical screening and evaluation of wound healing activity of the extracts in experimental model rats

Gurung

Koirala

Gurung

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Reinwardtia indica is traditionally used for wound healing. The main aim of this study was to evaluate the wound healing activity of leaves extracts of R. indica using the excision wound model in rats. The leaves of R. indica were collected from Gondrang, Chitwan, Nepal. Leaves were shade dried, extracted by double maceration and subjected to phytochemical screening. Then, the fusion method was used for the formulation of ointment and evaluated. Rats (n=24) were divided into four groups with 6 in each. Excision wound model was used, 2 cm diameter (314 mm 2 ), 2 mm depth wound was created. The treatment was given daily topically to all groups and the % mean wound contraction rate was calculated on days 4, 8, 12 and 16. The result was analyzed statistically using Graph pad prism version 5. Phytochemical test revealed the presence of alkaloid, flavonoid, tannin, phenol, terpenoid, carbohydrate, etc. All the evaluation parameters showed satisfactory results. The extract of R. indica ointment (2% w/w and 5% w/w) increased the wound contraction rate day by day. The % means wound contraction rate, on day 12, (80% and 88%), and on day 16, (97% and 100%) and statistically significant difference was at p<0.0001. The R. indica extract ointment showed an increased wound contraction rate. So, in further R. indica could be used for commercial production of wound healing ointment.

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Wound healing activity of the ethanol root extract and polyphenolic rich fraction fromPotentilla fulgens

Abstract: The present study provided the scientific evidence, where P. fulgens rich in polyphenolic components possess remarkable wound healing activities, thereby supporting the traditional claims.

Cited by 39 publications

References 33 publications

Nano formulated proanthocyanidins as an effective wound healing component

Nano formulated proanthocyanidins as an effective wound healing component

Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis

Reinwardtia indica: phytochemical screening and evaluation of wound healing activity of the extracts in experimental model rats

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