Wound healing and antimicrobial potential of Carissa spinarum Linn. in albino mice

Sanwal, Ritu; Chaudhary, Anand Kumar

doi:10.1016/j.jep.2011.04.025

Cited by 63 publications

(30 citation statements)

References 8 publications

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“…CvME hydrogel (1 and 2.5% w/w) was applied to the shaved portion at the back of the mice and observed for 14 days for an abnormal skin response, including irritation, redness, itching, and other related symptoms [14]. …”

Section: Methodsmentioning

confidence: 99%

Topical Application ofCleome viscosaIncreases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound

Upadhyay

Chattopadhyay

Goyary

et al. 2014

BioMed Research International

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Cleome viscosa L. (Cleomaceae) is an important traditional medicine of the Indian-Ayurvedic and Chinese-medicine system documented for rheumatic arthritis, hypertension, malaria, neurasthenia, and wound healing. The plant is also known as Asian spider flower and is distributed throughout the greater part of India. The present study explored the wound healing property of C. viscosa methanol extract (CvME) and its related mechanism using Wistar rat cutaneous excision wound model. Wound contraction rate, hydroxyproline quantification, and histopathological examination of wound granulation tissue were performed. The healing potential was comparatively assessed with a reference gentamicin sulfate hydrogel (0.01% w/w). Western blot for COL3A1, bFGF, and Smad-2, Smad-3, Smad-4, and Smad-7 was performed with 7-day postoperative granulation tissue. Results revealed that the topical application of CvME (2.5% w/w) significantly accelerated the wound contraction rate (95.14%, 24 postoperative days), increased the hydroxyproline content (3.947 mg/100 mg tissue), and improved histopathology of wound tissue as compared to control groups. Western blot analysis revealed that CvME significantly upregulated the expression of COL3A1 and bFGF and increased the Smad-mediated collagen production in granulation tissue. These findings suggest that C. viscosa promoted the wound repair process by attenuating the Smad-mediated collagen production in wound granulation tissue.

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Section: Methodsmentioning

confidence: 99%

Topical Application ofCleome viscosaIncreases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound

Upadhyay

Chattopadhyay

Goyary

et al. 2014

BioMed Research International

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“…Previous research has identified and reported that a number of natural products promote the wound healing process (Kim et al, 2011;Sanwal and Chaudhary, 2011). Acalypha indica (Family: Euphorbiaceae) is an annual erect herb growing as a weed in gardens and along road sides, which is distributed throughout the Indian sub-continent, Bangladesh and Srilanka.…”

Section: Introductionmentioning

confidence: 99%

Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I and III collagen

Ganeshkumar

Ponrasu

Krithika

et al. 2012

Journal of Ethnopharmacology

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“…A sample weighing 0.15 g of wound tissue was then hydrolyzed with 3 mL of 6 N hydrochloric acid for 24 h at 110°C in a sealed conical glass flask. The pH of the hydrolysate was neutralized to pH 8.0 ± 0.2 [26]. The supernatant solution (1 mL) was removed delicately with a pipette from each of the hydrolysates and submitted to the standard treatment.…”

Section: Methodsmentioning

confidence: 99%

In Vivo Wound Healing Activity of Abrus cantoniensis Extract

Zeng

Xie

Song

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Abrus cantoniensis (Leguminosae sp.) is a traditionally used remedy for treating rheumatism, blood stasis, and internal injuries. In order to reveal a new insight of the utilization of the plant, solvent extraction by ethyl acetate (EA) was performed in order to evaluate the plant extracts' in vivo excision and incision-wound potentials with models. The contents of the EA fraction, wound healing activity, acute oral toxicity, and acute dermal toxicity were studied. As a result, the main chemical constituents of the EA fraction were alkaloids, flavonoids, and steroids. The acute oral toxicity test results and assessment of skin hypoallergenicity showed that the plant extract was safe at LD50 as high as 5000 mg/kg. Both excision and incision model tests results indicated that the EA fraction of A. cantoniensis showed a significant wound healing capacity at a concentration of 5% (v/w) (p < 0.01) as observed by the increased wound contraction, decreased epithelialization time, and increased hydroxyproline content compared to the ones of the controls. The present study showed that the EA fraction of A. cantoniensis possesses potential wound healing activities and provided recent results for the use of A. cantoniensis for wound curing.

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Wound healing and antimicrobial potential of Carissa spinarum Linn. in albino mice

Cited by 63 publications

References 8 publications

Topical Application ofCleome viscosaIncreases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound

Topical Application ofCleome viscosaIncreases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound

Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I and III collagen

In Vivo Wound Healing Activity of Abrus cantoniensis Extract

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