Wound healing by homœopathic silicea dilutions in mice

Oberbaum, Menahem; Markovits, Robert; Weisman, Z; Kalinkevits, A; Bentwich, Zvi

doi:10.1016/s0007-0785(05)80956-1

Cited by 5 publications

(9 citation statements)

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“…High antioxidant activity, high biocompatibility, and protective effect on cells against hydrogen peroxide was observed for all nanocomposites, even for the samples with low content of C. asiatica glycolic extract. Given that, the obtained nanocomposite simultaneously could act as scavenger neutralizing and tissue regenerator creating the ideal condition to favor the skin repair 21,22 . Our synthetic approach is completely new and consists in the fine dispersion of drugs or natural extracts in a porous silica matrix by a simple ball milling one‐pot approach.…”

Section: Discussionmentioning

confidence: 99%

“…Given that, the obtained nanocomposite simultaneously could act as scavenger neutralizing and tissue regenerator creating the ideal condition to favor the skin repair. 21,22 Our synthetic approach is completely new up-scaling of effective products. 24,37 In fact, while technologies are in principle available for large-scale fabrication, production of biomaterials is still expensive because of high-cost raw materials and equipment needed for their manufacturing.…”

Section: Discussionmentioning

confidence: 99%

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Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Ebau

Scano

Manca

et al. 2022

J Biomedical Materials Res

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An innovative nanotechnology‐based approach was used for the preparation of Centella asiatica (C. asiatica) extract‐SiO2 nanocomposites, specifically tailored for skin protection from oxidative damage. Different amounts of C. asiatica glycolic extract (1.0, 3.0, 5.0, and 10.0 wt %) and fumed silica were used to prepare the nanocomposites by means of ball milling method. The influence of both composition of the starting mixture and milling time on the final products was evaluated by different techniques such as X‐ray powder diffraction, scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis, and nitrogen sorption analysis. Results confirmed the integrity of the natural extract after the milling process, and its successful loading in the silica matrix. No cytotoxicity was observed for the obtained nanocomposites, which showed high in‐vitro ability to scavenge 2,2‐diphenyl‐1‐picrylhydrazyl and to protect human keratinocytes from damages induced with hydrogen peroxide.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Ebau

Scano

Manca

et al. 2022

J Biomedical Materials Res

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“…Silicon acts on conjunctive structure level ensuring the integrity, tonicity and elasticity of cutaneous tissue by its bonds with collagen, proteoglycans and elastin. A silicon supply has many positive consequences on skin, such as better hydration and tonicity, accelerated hair growth, smoother and firmer skin, and faster healing of wounds and burns [25]. Various dermatitis such as eczema, psoriasis and acne can draw benefit from silica.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of protective and restoring effects of a mixture of silanols on photoaging. Use of a device allowing the quantification of contractile strengths of human fibroblasts after UVA irradiation

Robin¹,

Courderot-Masuyer²,

Tauzin³

et al. 2012

Intern J of Cosmetic Sci

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Chronic sun exposure and especially UVA wavelengths are responsible for long-term clinical skin changes such as photoageing and photocancers. The objectives of the present study were to analyse the contractile activity of fibroblasts irradiated with several doses of UVA and to evaluate the preventive, protective and restoring effects of a mixture of monomethylsilanetriol mannuronate and dimethylsilanediol salicylate. The forces generated by fibroblasts in tense collagen lattices were quantified using Glasbox device before and after UVA irradiation and the addition of a mixture of monomethylsilanetriol mannuronate and dimethylsilanediol salicylate. The production of collagen was also evaluated before and after irradiation and with and without the presence of a mixture of monomethylsilanetriol mannuronate and dimethylsilanediol salicylate. A dose of 3 J cm(-2) of UVA showed more than 50% of mortality in fibroblast population after 48 h and significant decreases in contractile forces developed by irradiated fibroblasts and collagen I production. One percentage of a mixture of monomethylsilanetriol mannuronate and dimethylsilanediol salicylate protected fibroblasts from UVA irradiation and made it possible to restore their capacity to the same level as fibroblasts that were not irradiated. It also tended to restore the capacity to synthesize collagen I. These results show that the use of the new device Glasbox makes it possible to evaluate a possible preventive and repairing effect of a cosmetic functional active on photoageing.

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“…46 In the other study, different potencies of silica (up to 200C) increased the speed of wound healing in mice in vivo. 47 In addition to demonstrating the action of homeopathic medicines on macrophage activity, these studies were classic experimental demonstrations of the similia principle.…”

Section: Immunopharmacological Activity Of Silicamentioning

confidence: 99%

Immunological models in high dilution research following M Bastide

Bonamin

Bellavite

2015

Homeopathy

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In 1994, Madeleine Bastide described experimental models in immunology that were used during the 1980s to investigate high dilution effects on several biological systems. She classified the available papers in four categories: High dilutions of antigens; High dilutions of thymus, bursa and other hormones; High dilutions of cytokines; Immunopharmacological activity of silica. The studies about high dilutions of antigens were not continued after this period, but gave rise to a long process of a series of in vitro models on antigens and histamine dilutions, that led to the demonstration of the biological modulation effects of these preparations on basophil degranulation. During this process, a multi-centre study was performed, with a high degree of reproducibility among different independent laboratories. The studies about high diluted cytokines, thymulin and other hormones opened a new line of scientific investigation, about the regulatory properties of endogenous substances prepared according to homeopathic methods. The most frequently studied substance, thymulin, when administered to mice at 5cH potency, is able to improve the activity of phagocytes in different experimental situations, such as viral, bacterial and parasitic infections. The immunopharmacological activity of silica was demonstrated, at that time, as an in vivo illustration of the homeopathic 'similia principle'. More recently, studies on silica have assumed another focus: the putative role of silica as active contaminant present in high dilutions. This paper presents a follow-up summary on these items, considering the evolution of discoveries from 1994 to 2014.

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Wound healing by homœopathic silicea dilutions in mice

Cited by 5 publications

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Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Evaluation of protective and restoring effects of a mixture of silanols on photoaging. Use of a device allowing the quantification of contractile strengths of human fibroblasts after UVA irradiation

Immunological models in high dilution research following M Bastide

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Wound healing by homœopathic silicea dilutions in mice

Cited by 5 publications

References 0 publications

Centella asiaticaextract‐SiO2 nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Centella asiaticaextract‐SiO2 nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Evaluation of protective and restoring effects of a mixture of silanols on photoaging. Use of a device allowing the quantification of contractile strengths of human fibroblasts after UVA irradiation

Immunological models in high dilution research following M Bastide

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Product

Resources

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Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage

Centella asiaticaextract‐SiO₂ nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage