Wound healing following demineralization of resected root ends in periradicular surgery

Craig, Kathleen R.; Harrison, John W.

doi:10.1016/s0099-2399(06)81360-9

Cited by 43 publications

(19 citation statements)

References 15 publications

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“…Hence, the term cementum-like tissue was used, mainly on the basis of the location of this mineralized tissue and some features observed on hematoxylin-eosin stained slides. Craig and Harrison (21) suggested that newly formed cementum originates from PDL-derived tissue. However, isolated cementum-like tissue was also found on the root-end filling surface without conjunction of the cementum on the lateral surface, and the thickness decreased toward peripheral in many sections (Fig.…”

Section: Discussionmentioning

confidence: 99%

Healing after Root-end Microsurgery by Using Mineral Trioxide Aggregate and a New Calcium Silicate–based Bioceramic Material as Root-end Filling Materials in Dogs

Chen

Karabucak

Wang

et al. 2015

Journal of Endodontics

120

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Introduction The purpose of this study was to compare healing after root-end surgery by using grey mineral trioxide aggregate (MTA) and EndoSequence Root Repair Material (RRM) as root-end filling material in an animal model. Methods Apical periodontitis was induced in 55 mandibular premolars of 4 healthy beagle dogs. After 6 weeks, root-end surgeries were performed by using modern microsurgical techniques. Two different root-end filling materials were used, grey MTA and RRM. Six months after surgery, healing of the periapical area was assessed by periapical radiographs, cone-beam computed tomography (CBCT), micro computed tomography (CT), and histology. Results Minimal or no inflammatory response was observed in the majority of periapical areas regardless of the material. The degree of inflammatory infiltration and cortical plate healing were not significantly different between the 2 materials. However, a significantly greater root-end surface area was covered by cementum-like, periodontal ligament–like tissue, and bone in RRM group than in MTA group. When evaluating with periapical radiographs, complete healing rate in RRM and MTA groups was 92.6% and 75%, respectively, and the difference was not statistically significant (P = .073). However, on CBCT and micro CT images, RRM group demonstrated significantly superior healing on the resected root-end surface and in the periapical area (P = .000 to .027). Conclusions Like MTA, RRM is a biocompatible material with good sealing ability. However, in this animal model RRM achieved a better tissue healing response adjacent to the resected root-end surface histologically. The superior healing tendency associated with RRM could be detected by CBCT and micro CT but not periapical radiography.

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Section: Discussionmentioning

confidence: 99%

Healing after Root-end Microsurgery by Using Mineral Trioxide Aggregate and a New Calcium Silicate–based Bioceramic Material as Root-end Filling Materials in Dogs

Chen

Karabucak

Wang

et al. 2015

Journal of Endodontics

120

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“…Based on previous animal studies using the dog model, it would appear that 60 days is an appropriate time to wait between completion of experimental procedure and sacrifice. Previous dog studies have evaluated healing at intervals shorter than 60 days (Craig & Harrison 1993, Torabinejad et al . 1995a,b,c, Douthitt et al .…”

Section: Discussionmentioning

confidence: 99%

“…A solution of 1% methylene blue (Excellence in Endodontics) was applied to the resected root face to outline the periodontal ligament (Cambruzzi & Marshall 1983). The resected root faces were burnished with a sponge applicator soaked in 10% solution of citric acid (pH 1) for 2 min (Register 1975, Polson & Proye 1982, Craig & Harrison 1993) and washed with sterile saline.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Diaket and MTA when used as root-end filling materials to support regeneration of the periradicular tissues

Regan

Gutmann

Witherspoon³

2002

Int Endod J

102

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“…The dog mandible model has been used extensively to investigate many aspects of healing following oral surgery ( Manni et al . 1986 , Hollinger & Kleinschmidt 1990, Johnson 1991, Craig & Harrison 1993). Whilst this model has proved to be very useful, it has some shortcomings that need to be addressed.…”

Section: Discussionmentioning

confidence: 99%

“…A solution of 1% methylene blue (Excellence in Endodontics) was applied to the resected root face to outline the periodontal ligament ( Cambruzzi & Marshall 1983). The resected root faces were then burnished with a sponge applicator soaked in a 10% solution of citric acid (pH 1) for 2 min ( Register 1975, Craig & Harrison 1993) and washed with sterile saline.…”

Section: Methodsmentioning

confidence: 99%

Response of periradicular tissues to growth factors introduced into the surgical site in the root‐end filling material

et al. 1999

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Wound healing following demineralization of resected root ends in periradicular surgery

Cited by 43 publications

References 15 publications

Healing after Root-end Microsurgery by Using Mineral Trioxide Aggregate and a New Calcium Silicate–based Bioceramic Material as Root-end Filling Materials in Dogs

Healing after Root-end Microsurgery by Using Mineral Trioxide Aggregate and a New Calcium Silicate–based Bioceramic Material as Root-end Filling Materials in Dogs

Comparison of Diaket and MTA when used as root-end filling materials to support regeneration of the periradicular tissues

Response of periradicular tissues to growth factors introduced into the surgical site in the root‐end filling material

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