Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Stachura, Albert; Khanna, Ishani; Krysiak, Piotr; Paskal, Wiktor; Włodarski, Paweł

doi:10.3390/ijms23158621

Cited by 27 publications

(11 citation statements)

References 143 publications

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“…When a diabetic sore or ulcer becomes infected, it can spread quickly. Cellulitis, osteomyelitis, and abscesses are serious medical conditions that need to be treated right away [ 46 ]. Even in the absence of infection-related symptoms such as fever or soreness, an elevated bacterial load is detrimental to wound, ulcer, and injury healing.…”

Section: Categorization Of Wounds Stages and Impaired Wound Healing I...mentioning

confidence: 99%

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

et al. 2023

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Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve several primary problems; therefore, their effectiveness is limited. As a result of their remarkable properties, bio-based materials have been demonstrated to have a significant impact on wound healing in recent years. In the wound microenvironment, bio-based materials can stimulate numerous cellular and molecular processes that may enhance healing by inhibiting the growth of pathogens, preventing inflammation, and stimulating angiogenesis, potentially converting a non-healing environment to an appropriately healing one. The aim of this present review article is to provide an overview of the mechanisms underlying wound healing and its pathophysiology. The development of bio-based nanomaterials for chronic diabetic wounds as well as novel methodologies for stimulating wound healing mechanisms are also discussed.

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Section: Categorization Of Wounds Stages and Impaired Wound Healing I...mentioning

confidence: 99%

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

et al. 2023

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“…NA is a precursor of two essential coenzymes, nicotinamide adenine dinucleotide (NAD) and NAD phosphate, both have a role in wound healing by stimulating epidermal regeneration and maintaining the epidermal barrier [47,48]. On the contrary, wound healing could be impaired by the activation of the protein tyrosine phosphatase 1B (PTP1B), an enzyme which mitigates the signaling of leptin and the activation of VEGF type 2 receptor, and thus inhibits the proliferative and angiogenic effects of both [44,49]. Interestingly, NA has been identified as a PTP1B inhibitor, which further explains its wound healing role [50].…”

Section: In Vivo Wound Healing Assaymentioning

confidence: 99%

Facile synthesis of zinc acetate/niacin MOFs for use in wound healing

Ashmawy,

Azzazy

2023

Biomed. Mater.

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Niacin (NA) and Zinc (Zn) were used to fabricate metal organic frameworks (Zn-NA MOFs), based on coordination chemistry via a simple, rapid technique conducted at room temperature. The identity of the prepared MOFs was confirmed by FTIR, XRD, SEM, and TEM, which showed cubic shaped, crystalline, microporous MOFs with an average size of 150 nm. Release of the active ingredients from the MOFs was proved to be pH dependent in a slightly alkaline medium (pH 8.5) with a sustained release rate of its two ingredients, NA and Zn, which have wound healing activity. Zn-NA MOFs proved to be biocompatible in the tested concentrations range (5 - 100 mg/mL), with no cytotoxic effect on WI-38 cell line. Zn-NA MOFs at 10 and 50 mg/mL concentrations and their components, NA and Zn, exerted antibacterial effects against S. aureus, E. coli, and P. aeruginosa. Wound healing effect of the Zn-NA MOFs (50 mg/mL) was evaluated on full excisional rat wounds. Significant reduction of the wound area was observed after 9 days of treatment using the Zn-NA MOFs compared to the other treatment groups. Additionally, wounds were fully healed after 10 days of treatment with the Zn-NA MOFs with histological and immunohistochemical evidence of re-epithelization, collagen formation, and angiogenesis. Similar histological evidence was also observed in wounds treated with niacin only; however, with no significant wound closure rates. Nevertheless, the formation of new blood vessels, as confirmed by the VEGF protein expression, was highest in the niacin group. Zn-NA MOFs synthesized using a facile, low-cost method are potentially capable of healing wounds rapidly and effectively. 

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“…All of these have resulted in the development of skin ulcers and even gangrene in the foot [3]. Existing treatments for DCU consist of anti-infection, hyperbaric oxygen therapy, negative pressure drainage and minimally invasive surgical treatment [4][5][6], whereas DCU healing is slow, and DU has high recurrence rates [7]. The flow chart of this article is as follows (Fig.…”

Section: Introductionmentioning

confidence: 99%

Study on the regulatory effect of Panax notoginseng saponins combined with bone mesenchymal stem cell transplantation on IRAK1/TRAF6-NF-κB pathway in patients with diabetic cutaneous ulcers

Chen

et al. 2023

J Orthop Surg Res

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Panax notoginseng saponins (PNSs) have been found as the major active ingredient of Panax notoginseng (Burkill) F.H.Chen (PN) leaves, which has the effect of reducing inflammatory response, facilitating fibroblast proliferation, as well as promoting angiogenesis. This study aimed to investigate the molecular basis of PNS combined with bone mesenchymal stem cells (BMSCs) for treating diabetic cutaneous ulcers (DCU) and its mechanism of action. Methods. A total of 75 SD rats were selected to make diabetic cutaneous ulcers model. According random number table method, the rats were randomly divided into a control group, a DCU group, a BMSCs group, a PNS group and BMSCs + PNS group. Five groups of rats were given without treatment. After being treated for 7 days, the rats were anesthetized with pentobarbital, and granulation tissue was collected from the central point of the wound. They were used for pathological analysis, Western blot (WB) and polymerase chain reaction (PCR) assays. Results. The wound healing area was the largest in the BMSCs + PNS group. HE staining results showed that the PNS + BMSCs group could promote the formation of new epidermis and reduce the infiltration of inflammatory cells. Immunohistochemistry (IHC) results showed that the PNS + BMSCs group could up-regulate the expression of Ki67 protein and cell proliferation. In addition, PNS combined with BMSCs up-regulated the expression of miR-146-5p and down-regulated the expression of IL-1β, IL-6 and TNF-α, IRAK1, TRAF6 and p65 in the NF-κB signaling pathway (p < 0.05). Conclusions. PNS combined with bone mesenchymal stem cell transplantation up-regulated miR-146a-5p targeting and binding to IRAK1/TRAF6, inhibiting the activation of NF-κB pathway, which reduced the inflammatory response of DCU and facilitated the skin healing of DCU. Thus, this study provides a theoretical basis and a novel therapeutic option for the treatment of DFU with PNS combined with BMSCs.

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Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

Cited by 27 publications

References 143 publications

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

Facile synthesis of zinc acetate/niacin MOFs for use in wound healing

Study on the regulatory effect of Panax notoginseng saponins combined with bone mesenchymal stem cell transplantation on IRAK1/TRAF6-NF-κB pathway in patients with diabetic cutaneous ulcers

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