Wound healing in animals: a review of physiology and clinical evaluation

Lux, Cassie N.

doi:10.1111/vde.13032

Cited by 39 publications

(37 citation statements)

References 103 publications

(470 reference statements)

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“…Wound healing is a complicated process and paws are considered to have an increased risk for microbial contamination during healing as they are both difficult to protect and clean. 5 Manuka honey has antimicrobial activity and chemical properties that enhance wound healing and tissue regeneration. 6,7 A longer healing period was not noted in the cases showing presence of micro-organisms on culture compared to the other cases in this study.…”

Section: Discussionmentioning

confidence: 99%

A retrospective case series of the postoperative outcome for 30 dogs with inflammatory interdigital nodules, surgically treated with carbon dioxide laser and a nonantimicrobial wound‐healing protocol

Frey

Varjonen

2023

Veterinary Dermatology

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Background Inflammatory interdigital nodules (IIN) affecting the paws of dogs is a multifactorial and painful condition. Surgery using carbon dioxide (CO 2 ) laser has been shown to be helpful in the management. Hypothesis/Objectives To assess a postoperative treatment protocol without use of antibiotics following CO2 laser surgery for IIN treatment. Animals Forty‐seven paws, in 30 client‐owned dogs, with IINs affecting the interdigital web between the 4th and 5th digits of the forepaws, surgically treated using CO2 laser, were included. Materials and Methods Medical records were reviewed for demographic details, medication use and wound healing using a set wound care protocol. Time to resolution of the surgical wounds and the postoperative outcome were assessed. Results The mean healing time was 34 days. Resolution was seen in 42 of 47 paws with complications in five paws (11%), including development of new fistulae or nonhealing granulation tissue. Surgery was repeated in those five cases. Relapse occurred during the follow‐up period of five–19 months in six paws (13%). Conclusions and Clinical Relevance This study shows that surgical treatment with CO2 laser for interdigital nodules is successful in most cases. The postoperative outcome using a wound‐healing protocol avoiding use of antimicrobials can be used without compromising patient care whilst following antimicrobial stewardship guidelines.

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Section: Discussionmentioning

confidence: 99%

A retrospective case series of the postoperative outcome for 30 dogs with inflammatory interdigital nodules, surgically treated with carbon dioxide laser and a nonantimicrobial wound‐healing protocol

Frey

Varjonen

2023

Veterinary Dermatology

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“…During this stage, all the cellular processes activated post-injury wind down and come to an end, the new epithelium is formed, and the final scar tissue develops. The granulation tissue formation ceases via cellular apoptosis, leading to an acellular and avascular mature wound [57]. Majority of the cellular components exit from the wound site or undergo apoptosis, and the resulting mass consists of collagen and other ECM proteins.…”

Section: Maturation and Remodeling Phase (Day 10-1 Year)mentioning

confidence: 99%

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

Soni¹,

Singla²,

Padwad³

2023

Wound Healing - Recent Advances and Future Opportunities

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Wound-healing cascade is highly dynamic and composed of four continuous but overlapping phases that are precisely programmed. Successful healing occurs when these phases occur sequentially in a specific time frame and thus require multipotent wound-healing material. Nanotechnology has revolutionized the field of wound dressings by the development of various types of nanotechnology-based drug delivery systems and materials to treat hard-to-heal wounds. In this chapter, the advantages and the limitations associated with nanoparticle-based wound-healing materials as well as recent trends and applications of nanotechnology-based approaches in advanced wound therapy for healing of cutaneous, chronic, and burn wounds will be detailed along with the molecular interventions involved. Efforts are targeted herein to address the most significant factors affecting cutaneous wound healing and the molecular mechanisms involved. This chapter describes several nanoparticle (NP)-based drug delivery systems to improve the healing potential of antimicrobial, antifungal, growth factors, and other bioactive agents. While much remains to be learned, a better understanding of the factors influencing wound repair and nanotechnological interventions therein may lead to therapeutics that improve the healing process.

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“…Severe tissue trauma and presence of wound contamination leading to infection are common causes of delayed healing and failed wound closure, and strategies for their management are discussed in detail in this article. A review of the physiology of wound healing has been published recently 3 …”

Section: Introductionmentioning

confidence: 99%

Local wound management: A review of modern techniques and products

Aisa

Parlier

2022

Veterinary Dermatology

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Management of wounds is a commonly performed and essential aspect of small animal veterinary medicine. Appropriate wound management is a difficult art to master, due to the inherent complexity of the clinical scenario, as well as the ever-evolving nature of the field with the constant addition of new products and techniques. This article reviews key concepts that may help the practitioner better understand the natural process of wound healing, factors that delay healing and strategies to help improve the local wound environment to make it more conducive to healing during open wound management. The concept of wound bed preparation is defined before common local wound management strategies, such as wound lavage and debridement, are discussed in more detail. Key aspects of the management of biofilms and appropriate use of antimicrobial agents are also reviewed. Finally, the concept of moist wound healing and its impact in modern wound management is explained before a broad variety of types of wound dressings are reviewed, with a particular focus on active dressings.

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Wound healing in animals: a review of physiology and clinical evaluation

Cited by 39 publications

References 103 publications

A retrospective case series of the postoperative outcome for 30 dogs with inflammatory interdigital nodules, surgically treated with carbon dioxide laser and a nonantimicrobial wound‐healing protocol

A retrospective case series of the postoperative outcome for 30 dogs with inflammatory interdigital nodules, surgically treated with carbon dioxide laser and a nonantimicrobial wound‐healing protocol

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

Local wound management: A review of modern techniques and products

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