Wound healing in post-smolt Atlantic salmon (Salmo salar L.)

Sveen, Lene; Timmerhaus, Gerrit; Krasnov, Aleksei; Takle, Harald; Handeland, Sigurd O.; Ytteborg, Elisabeth

doi:10.1038/s41598-019-39080-x

Cited by 59 publications

(70 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the same group later reported that melanin-based pigmentation significantly correlated with the immunocompetence of Atlantic salmon and its resistance to sea lice [51]. A recent study found hyperpigmentation and migrating pigment bodies at the wound surface and implicated it with wound repairing processes in Atlantic salmon [52]. It may be argued that parasite-mediated inhibition of melanin synthesis could be a potential mechanism supporting the lice pathology.…”

Section: Chalimus Infection Influences Transcription Machinery Energmentioning

confidence: 96%

Transcriptomic Profiling in Fins of Atlantic Salmon Parasitized with Sea Lice: Evidence for an Early Imbalance Between Chalimus-Induced Immunomodulation and the Host’s Defense Response

Umasuthan

Xue

Caballero‐Solares

et al. 2020

IJMS

View full text Add to dashboard Cite

Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated the early transcriptomic responses in pelvic fins of Atlantic salmon parasitized with chalimus I stage sea lice. Fin samples collected from non-infected (i.e., pre-infected) control (PRE) and at chalimus-attachment sites (ATT) and adjacent to chalimus-attachment sites (ADJ) from infected fish were used in profiling global gene expression using 44K microarrays. We identified 6568 differentially expressed probes (DEPs, FDR < 5%) that included 1928 shared DEPs between ATT and ADJ compared to PRE. The ATT versus ADJ comparison revealed 90 DEPs, all of which were upregulated in ATT samples. Gene ontology/pathway term network analyses revealed profound changes in physiological processes, including extracellular matrix (ECM) degradation, tissue repair/remodeling and wound healing, immunity and defense, chemotaxis and signaling, antiviral response, and redox homeostasis in infected fins. The QPCR analysis of 37 microarray-identified transcripts representing these functional themes served to confirm the microarray results with a significant positive correlation (p < 0.0001). Most immune/defense-relevant transcripts were downregulated in both ATT and ADJ sites compared to PRE, suggesting that chalimus exerts immunosuppressive effects in the salmon’s fins. The comparison between ATT and ADJ sites demonstrated the upregulation of a suite of immune-relevant transcripts, evidencing the salmon’s attempt to mount an anti-lice response. We hypothesize that an imbalance between immunomodulation caused by chalimus during the early phase of infection and weak defense response manifested by Atlantic salmon makes it a susceptible host for L. salmonis.

show abstract

Section: Chalimus Infection Influences Transcription Machinery Energmentioning

confidence: 96%

Transcriptomic Profiling in Fins of Atlantic Salmon Parasitized with Sea Lice: Evidence for an Early Imbalance Between Chalimus-Induced Immunomodulation and the Host’s Defense Response

Umasuthan

Xue

Caballero‐Solares

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…2016; Sveen et al . 2019). If the deeper dermal tissue is damaged, a strong pigmentation response can be seen in the healing wound, together with the repair mechanisms of fibrous tissue (Fig.…”

Section: Techniques To Inflict Skin Damage In Fish For Experimental Pmentioning

confidence: 99%

“…2013; Schmidt 2013; Sveen et al . 2019). This cascade shares many similarities with the classical wound healing cascade in mammals.…”

Section: Healing Of Mechanical Induced Wounds In Fish Skinmentioning

confidence: 99%

“…The wounds slightly expand before contraction. Panel (a and b), Photograph: Jacob Schmidt (Schmidt, 2013; Sveen et al, 2019).…”

Section: Healing Of Mechanical Induced Wounds In Fish Skinmentioning

confidence: 99%

“…Despite this, genes involved in haemostasis and blood coagulation are active during the first days after wound infliction (Sveen et al . 2019). An amorphous substrate filling the wound has also been identified by several authors (Roubal & Bullock 1988; Sveen et al .…”

Section: Healing Of Mechanical Induced Wounds In Fish Skinmentioning

confidence: 99%

See 2 more Smart Citations

Mechanical induced wounds in fish – a review on models and healing mechanisms

Sveen

Karlsen

Ytteborg

2020

Reviews in Aquaculture

Self Cite

View full text Add to dashboard Cite

Skin wounds and injuries are frequently occurring in farmed fish, particularly in more intensive production systems. Any disruptions of the skin, such as mucus removal, scale loss or deeper incisions, are negatively correlated with barrier functions and disease resistance. In this review, the current knowledge on mechanically induced wounds in fish is dedicated to five areas of focus: (i) The anatomy and functions of fish skin, (ii) Techniques to inflict mechanical skin damage in farmed and laboratory fish for experimental purposes, (iii) Healing mechanisms of deep wounds, (iv) In vitro models for wound healing studies and (v) Wound care, with focus on factors that may enhance or delay skin regenerative processes. The aim of the review was to presents key points for a better understanding of skin resilience and fish robustness, with focus on Atlantic salmon, Salmo salar, in Norwegian coastal production environment.

show abstract

Effects of Juniperus root extract on wound healing, gene expression, and biochemical response in yellowtail acei Pseudotropheus sp. fish

Önalan,

Kankaya

2024

Aquacult Int

View full text Add to dashboard Cite

Injuries are an undesirable situation in fish kept in aquariums. The use of antibiotics in wound healing is not preferred due to the development of antibiotic resistance in bacteria and for economic reasons. This study was conducted to demonstrate the efficacy of Juniperus root extract in healing experimentally induced incised wounds in yellowtail acei. Wound closure time, morphology, malondialdehyde content, glutathione s-transferase activity, changes in gene expression levels, non-dispersibility of the extract in aqueous environment, and retention on the wound were analyzed. In the antibiotic group, the scarring of the wound was observed on the sixth day. On the other hand, in the root extract group, wound healing was completed on the second day. In addition, a significant decrease in malondialdehyde and glutathione s-transferase levels was observed in the extract group compared to the control group. It was found that SWS2a, RH2B, and LWS gene expression levels started to decrease during wound healing at the end of the second day in the extract-treated group. In the antibiotic group, the same effect was observed on the seventh day. Important properties of the extract used, such as not dispersing in the water environment and remaining on the wound, were also determined. It would be useful to continue the experiments with Juniperus root extract, which has been shown to be effective in wound healing, with microscopic studies on aquaculture and diseases.

show abstract

Wound healing in post-smolt Atlantic salmon (Salmo salar L.)

Cited by 59 publications

References 55 publications

Transcriptomic Profiling in Fins of Atlantic Salmon Parasitized with Sea Lice: Evidence for an Early Imbalance Between Chalimus-Induced Immunomodulation and the Host’s Defense Response

Transcriptomic Profiling in Fins of Atlantic Salmon Parasitized with Sea Lice: Evidence for an Early Imbalance Between Chalimus-Induced Immunomodulation and the Host’s Defense Response

Mechanical induced wounds in fish – a review on models and healing mechanisms

Effects of Juniperus root extract on wound healing, gene expression, and biochemical response in yellowtail acei Pseudotropheus sp. fish

Contact Info

Product

Resources

About