Wound healing in the fetal period: The resistance of the scar to rupture

Use of Bipedicular Advancement Flaps for Intrauterine Closure of Myeloschisis

“…It was further hoped that we could take advantage of the superior healing of the fetus [15, 16, 17, 18, 19, 20]. Unfortunately, this did not turn out to be the case.…”

An in-vivo experimental model for studying wound-healing after laser irradiation in the mouse foetus

“…Most previous studies on the healing of foetal burn did not show recovery (Dixon, 1960;Juria et al, 1993;Sancho et al, 1997). Juria et al (1993) compared foetal skin healing in three types of wounds in rabbit foetuses, a sutured wound, a non-sutured wound and a burn.…”

“…Juria et al (1993) compared foetal skin healing in three types of wounds in rabbit foetuses, a sutured wound, a non-sutured wound and a burn. They reported that a burn induced using electrocautery did not close, while a sutured wound recovered perfectly.A burn induced by direct contact between foetal skin and electrocautery may be more severe.…”

Learning from regeneration research organisms: The circuitous road to scar free wound healing

“…At the end of the remodeling process the tensile strength of the scar is only up to 70% of intact skin and thus results in tough inflexible scar tissue (Fig. 2) (Finsterbush et al, 1982; Julia et al, 1993; Morin et al, 1989; van Zuijlen et al, 2003)…”

“…Additionally, TGFβ3 is highly expressed in fetal keratinocytes and fibroblasts but minimally expressed or absent in adult wound beds (Penn et al, 2012; Walraven et al, 2014). Furthermore, adult wounds express high levels of platelet-derived growth factor (PDGF) but this is absent from fetal wounds (Buchanan et al, 2009; Hantash et al, 2008; Helmo et al, 2013; Julia et al, 1993; Kishi et al, 2012; Wilgus, 2007). Interestingly, some success has been seen with treating wounds in rat with ectopic TGFβ3 resulting in less scar tissue formation (O'Kane and Ferguson, 1997; Shah et al, 1995).…”