Wound healing of laser injured skin with glycerol monooleicate cubic liquid crystal

Ma, Peipei; Li, Ruiteng; Zhu, Lin; Yu, Xiang; Zhu, Siqing; Pang, Lulu; Ma, Jinqiu; Du, Lina; Jin, Yiguang

doi:10.1016/j.burns.2020.03.016

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Further research is needed to elucidate the exact mechanism and determine if observed effects on tissue healing and regeneration are secondary to GaPP-LCNP’s effects on bacterial clearance. Interestingly, GMO-based LCNP has recently been shown to promote the healing of non-infected wounds caused by laser burns through helping maintain wound homeostasis [ 52 ]. Taken together, the high antibacterial activity of GaPP-LCNP demonstrated in this study, combined with the high safety profile and positive impact on wound healing, justifies further pre-clinical studies using higher light doses to disclose the full potential of GaPP-LCNP as a promising treatment for infected chronic wounds.…”

Section: Resultsmentioning

confidence: 99%

Lipid Liquid Crystal Nanoparticles: Promising Photosensitizer Carriers for the Treatment of Infected Cutaneous Wounds

et al. 2023

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Cutaneous chronic wounds impose a silent pandemic that affects the lives of millions worldwide. The delayed healing process is usually complicated by opportunistic bacteria that infect wounds. Staphylococcus aureus is one of the most prevalent bacteria in infected cutaneous wounds, with the ability to form antibiotic-resistant biofilms. Recently, we have demonstrated the potential of gallium protoporphyrin lipid liquid crystalline nanoparticles (GaPP-LCNP) as a photosensitizer against S. aureus biofilms in vitro. Herein, we investigate the potential of GaPP-LCNP using a pre-clinical model of infected cutaneous wounds. GaPP-LCNP showed superior antibacterial activity compared to unformulated GaPP, reducing biofilm bacterial viability by 5.5 log10 compared to 2.5 log10 in an ex vivo model, and reducing bacterial viability by 1 log10 in vivo, while unformulated GaPP failed to reduce bacterial burden. Furthermore, GaPP-LCNP significantly promoted wound healing through reduction in the bacterial burden and improved early collagen deposition. These findings pave the way for future pre-clinical investigation and treatment optimizations to translate GaPP-LCNP towards clinical application.

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Section: Resultsmentioning

confidence: 99%