Wound-healing potential of curcumin loaded lignin nanoparticles

Alqahtani, Mohammed S.; Alqahtani, Ali S.; Kazi, Mohsin; Ahmad, Muhammad Zamharir; Alahmari, Abdullah K.; Alsenaidy, Mohammad A.; Syed, Rabbani

doi:10.1016/j.jddst.2020.102020

Cited by 70 publications

(45 citation statements)

References 55 publications

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“…It may also accelerate hemostasis and tissue regeneration (Liu et al, 2018). The advent of nanotechnology has opened new avenues for designing innovative and efficient therapies to overcome the barriers faced by conventional therapies (Huang et al, 2018;Zhong et al, 2019;Alqahtani et al, 2020;Wang et al, 2020;Faraji et al, 2021). Thiolation of the polymers is a novel approach for improving the healing properties of polymers and alleviating associated side effects.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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“…Several synthesis methods have been created and studied for LNPs preparation, such as acid precipitation [ 23 ], solvent-shifting [ 24 , 25 ], direct dialysis [ 21 ], ultrasonication [ 14 ], and homogenization [ 18 ]. Table 1 elaborates the advantages and drawbacks of each established method in synthesizing LNPs.…”

Section: Lignin Nanoparticles (Lnps)mentioning

confidence: 99%

“…As anti-inflammatory nanoparticles, LNPs can play an important role in the wound healing process. Alqahtani et al [ 24 ] studied empty LNPs treatment, which could fasten the wound closure, where approximately 77% of wounds closed after 12 days. This was faster than untreated wounds and equal to curcumin-treated wounds.…”

Section: Lignin Nanoparticles (Lnps)mentioning

confidence: 99%

“…Several previous studies have proven this issue, where LNPs had no significant effect on cell viability. Alqahtani et al [ 20 , 24 ] reported that the cell viabilities of Caco-2 cells and human keratinocyte HaCaT cells after LNPs treatment were above 80% and 98.69% with no significant differences from the untreated cells. Another study investigated the effect of LNPs treatment on several cancer cell lines, such as MDA-MB-231, MCF-7 (breast epithelial cells), PC3-MM2 (prostate epithelial cell), and Caco-2 (colon epithelial cell), and non-tumor cells, such as KG1 (bone marrow macrophage cell) and EA.hy926 (vein endothelial cell) [ 32 ].…”

Section: Lignin Nanoparticles (Lnps)mentioning

confidence: 99%

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A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

2021

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Due to their biocompatibility, biodegradability, and non-toxicity, lignocellulosic-derived nanoparticles are very potential materials for drug carriers in drug delivery applications. There are three main lignocellulosic-derived nanoparticles discussed in this review. First, lignin nanoparticles (LNPs) are an amphiphilic nanoparticle which has versatile interactions toward hydrophilic or hydrophobic drugs. The synthesis methods of LNPs play an important role in this amphiphilic characteristic. Second, xylan nanoparticles (XNPs) are a hemicellulose-derived nanoparticle, where additional pretreatment is needed to obtain a high purity xylan before the synthesis of XNPs. This process is quite long and challenging, but XNPs have a lot of potential as a drug carrier due to their stronger interactions with various drugs. Third, cellulose nanocrystals (CNCs) are a widely exploited nanoparticle, especially in drug delivery applications. CNCs have low cytotoxicity, therefore they are suitable for use as a drug carrier. The research possibilities for these three nanoparticles are still wide and there is potential in drug delivery applications, especially for enhancing their characteristics with further surface modifications adjusted to the drugs.

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“…The cost is expected to increase sharply to US $24.8 billion by 2024 3 . Therefore, proper wound healing is important in order to reduce costs and prevent chronic wounds 4 .…”

Section: Introductionmentioning

confidence: 99%

The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure

David Setyo Budi,

Reny I`tishom,

Alphania Rahniayu

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Disruption to healing process results on longer healing duration from the timeline. Povidone iodine and tulle are common management in wound care. The advance of industry in health sector and the availability of natural ingredients in Indonesia provide opportunities for developing alternatives for wound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial, and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan can maintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potential of turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with "post-test only control group design". The sample consisted of 30 mice which were assigned into 5 groups. Result: All experimental groups experienced a gradual decrease in wound length. The statistical test results for groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group I did not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but it had significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate the reduction of wound length.

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Wound-healing potential of curcumin loaded lignin nanoparticles

Cited by 70 publications

References 55 publications

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure

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