Wound healing potential of methanolic extract of Trichosanthes dioica Roxb (fruits) in rats

Shivhare, Yogesh; Singour, Pradeep Kumar; Patil, UK; Pawar, Rajesh Singh

doi:10.1016/j.jep.2009.12.015

Cited by 58 publications

(41 citation statements)

References 20 publications

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“…The thin sections were cut and stained with haematoxylin and eosin [25][26][27] and observed under microscope for the histopathological changes such as fibroblast proliferation, collagen formation.…”

Section: Histopathological Examinationsmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Histopathological Examinationsmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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“…The genetic response regulating the body's own cellular resistance mechanisms contributes to the wound and its repair (Shivhare et al, 2010). Therefore in this study two different models were used to establish the healing potentials of aqueous and ethanolic extracts of Morus alba on various phases.…”

Section: Discussionmentioning

confidence: 99%

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

Kaushik¹

2013

American Journal of Pharmacology and Toxicology

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To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.

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“…Wound healing consists of four overlapping processes viz: granulation, fibroblast proliferation, collagenization and epithelialization. These processes occur in organized cascade culminating in restoration of anatomical continuity and function (Savunen and Viljanto, 1992; Shivhare et al, 2010). A major impediment to wound healing is contamination of wounds by bacteria (Darr et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of wound healing and antibacterial properties of methanolic root extract of <i>Stephania dinklagei</i> (Engl.) Diels

Udegbunam¹,

Igbokwe²,

Udegbunam³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Stephania dinklagei Diels (Engl.) is used in folkloric medicine in Southeastern Nigeria for the treatment of wounds and some bacterial-associated infections. This study evaluated the wound healing and antibacterial potential of Stephania dinklagei to validate or invalidate its folkloric use. Materials and Methods:The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of methanolic extract of S. dinklagei root (MESDR) against Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella spp. was determined by macro broth dilution. The extract at 20% and 10% were dosed orally to rats at 300mg/kg body weight (bw) in incision and dead space wound healing model to determine wound tensile strength and granulation tissue weight, respectively. The same extract concentrations were applied topically in excision wound model to determine the rate of wound contraction and epithelialization. Activities of superoxide dismutase (SOD) and catalase (CAT), and the levels of total protein (TP), malondialdehyde (MAL), hydroxyproline (HYP) and hexosamine (HEX) in excision wound biopsies were determined at days 7 and 14 post-wounding (pw). In the excision wound model, the extract concentrations were compared with gentamicin sulphate. Results: The MIC of S. dinklagei extract against P. aeruginosa, S. aureus, B. subtilis, E. coli and Klebsiella spp. were 8mg/ml, 3 mg/ml, 5mg/ml, 6mg/ml and 7mg/ml, respectively, while the corresponding MBC were 10 mg/ml, 5 mg/ml, 7mg/ml, 8mg/ml, and 9 mg/ml, respectively. The 20% extract gave significantly (P<0.05) higher tensile strength and granulation tissue weight than the 10% and gentamicin sulphate. Wound contraction and epithelialization occurred significantly (P<0.05) better and faster in wounds of animals treated with the 20% extract and gentamicin sulphate compared to those treated with 10% extract. TP of animals treated with 20% extract and those treated with the reference drug did not vary significantly (P>0.05) at day 14 pw. SOD and CAT activities, and MDA and HEX level of all the groups did not vary significantly (P>0.05) at day 14 pw. HYP level of the extract-treated groups significantly (P<0.05) decreased against the control. No significant difference existed in HYP level between the extract-treated groups. Conclusions: S. dinklagei possess antibacterial and wound healing properties which are comparable to those of gentamicin sulphate.

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Wound healing potential of methanolic extract of Trichosanthes dioica Roxb (fruits) in rats

Cited by 58 publications

References 20 publications

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

Evaluation of wound healing and antibacterial properties of methanolic root extract of <i>Stephania dinklagei</i> (Engl.) Diels

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