Wound healing promoting activity of stem bark extract ofSemecarpus anacardiumusing rats

Abstract

The wound healing promoting property of stem bark methanol extract of Semecarpus anacardium was evaluated at three different dosages by excision, incision and dead space wound models using Wistar albino rats. Framycetin skin ointment was used as standard. LD(50) of methanol extract was determined to be 500 mg kg(-1). In methanol extract (20% ointment) treated group, epithelialisation of the incision wound was faster with a high rate of wound contraction. The tensile strength of the incision wound was significantly increased when compared to other treated groups. The histological examination of the dead space wound model granulation tissue of the methanol extract (100 mg kg(-1)) treated group showed increased cross-linking of collagen fibres and absence of monocytes as compared to control. Methanol extract at 100 mg kg(-1) exhibited significant wound healing activity but was lesser than standard; whereas, in animals treated with 50 and 75 mg kg(-1) showed moderate activity. This investigation supported the ethnomedicinal claims of S. anacardium.

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

“…Several plants have been experimentally used as traditional medicines to treat skin disorders and wound injuries. 1 Pistacia atlantica (P. atlantica) trees grow in large populations in the western, central and eastern parts of Iran. The fruits of P. atlantica, which have been used traditionally in treatment of peptic ulcers 2 are called "Bene" in Iran and have been utilized as food.…”

The current status of old traditional medicine introduced from Persia to China

“…The nut milk extract demonstrated remarkable hypolipidemic activity in hypercholesterolemic rats (Vinayagam et al, 2012). The methanol extract of the stem bark promotes wound healing and this was shown using a rat model (Lingaraju et al, 2012). The pericarp can be prepared like tea to relieve flatulence following severe piles in Iran (Pasrsa, 1960).…”

Bhallatakadi Ghrita: Development and evaluation with reference to Murcchana and Shata-Dhauta process

“…Semecarpus anacardium L., Argemone mexicana L., Cocculus hirsutus L. and Woodfordia fruticosa K. are reported for their wound healing potential by the tribal or local community in traditional and folk medicinal practices [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ]. The cow ghee increases the potency of certain herbal ingredients by carrying the lipid soluble active components to the interior of the cell [ 9 ].…”