Wound Healing Property of Curcuminoids as a Microcapsule-Incorporated Cream

Ang, Lee Fung; Darwis, Yusrida; Koh, Rhun Yian; Leong, Kenny Voon Gah; Yew, Mei Yeng; Por, Lip Yee; Yam, Mun Fei

doi:10.3390/pharmaceutics11050205

Cited by 13 publications

(4 citation statements)

References 52 publications

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“…Then, the coacervate formed was frozen overnight at -70°C followed by freezedrying. Freeze-dried microcapsules were stored in airtight glass vials, protected from light, and stored in a desiccator [33].…”

Section: Examples Of Surfactant Use In Variousmentioning

confidence: 99%

Review of Surfactant Use in Curcumin Drug Delivery System

Rostinawati

2022

J. Kartika Kimia

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Curcuminoids are the active components of the dried rhizome of Curcuma longa Linn. Curcuminoids consist of the three most basic constituents: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Traditionally, turmeric is widely used to treat flatulence, liver, menstrual disorders, hematuria, bleeding, and colic. With more research, turmeric's benefits are increasing, ranging from anti-inflammatory, cancer, autoimmune, neurological, cardiovascular disease, and diabetes. However, this is limited by the Physicochemical properties of curcumin which is not soluble in water; its metabolism is fast, and it is unstable in physiological pH and alkaline, causing low bioavailability and resulting in less optimal therapeutic effect. Currently, several drug delivery systems have been developed to improve the bioavailability of curcumin, such as adjuvants, liposomes, nanoparticles, curcumin-phospholipid complexes, curcumin structural analogs, micronization, and nanonization, Self Micro Emulsifying Drug Delivery Systems (SMEDDS), cyclodextrin inclusions, solid dispersions, nanoemulsions, nano balls, nanobeads, and nanofibers. Many of these preparations use the help of surfactants. Surfactants are used as emulsifiers, wetting agents, and solvents. In principle, surfactants help reduce surface tension and interfacial tension in gases, liquids, and solids, allowing these substances to diffuse and spread. Factors that must be considered when selecting a surfactant are the critical micelle concentration and the HLB value. Selection of the right surfactant will help increase bioavailability.

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Section: Examples Of Surfactant Use In Variousmentioning

confidence: 99%

Review of Surfactant Use in Curcumin Drug Delivery System

Rostinawati

2022

J. Kartika Kimia

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“…In traditional Chinese medicine, curcuminoids are used for the treatment of burns and other wounds. Microencapsulation of curcuminoids using gelatin B and chitosan showed a significant effect on wound healing, with increased wound closure rate and better epithelialization [23].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory Effects and Ability to Stimulate Wound Healing of a Common-Plantain Extract in Alginate Gel Formulations

Bâldea,

Lung,

Opriş

et al. 2023

Gels

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Our study aimed to investigate the biological effects of a common-plantain (Plantago major L.) extract, encapsulated in alginate, on dermal human fibroblast cultures in vitro, in view of its potential use as a wound healing adjuvant therapy. Common-plantain extracts were obtained by infusion and ultrasound extraction, and their total polyphenolic content and antioxidant capacity were determined by spectrophotometry. The best extract, which was obtained by infusion, was further encapsulated in sodium alginate in two different formulations. Fourier Transform Infrared Spectroscopy (FTIR) was used to demonstrate the existing interactions in the obtained common-plantain extract in the alginate formulations. The encapsulation efficiency was evaluated based on the total polyphenol content. These alginate gel formulations were further used in vitro to determine their biocompatibility and antioxidant and anti-inflammatory effects by spectrophotometry and ELISA, as well as their ability to stimulate fibroblast migration (scratch test assay) at different time points. In addition, the collagen 1 and 3 levels were determined by Western blot analysis. The data showed that the microencapsulated plantain extract formulations induced an antioxidant, anti-inflammatory effect, enhanced collagen production and increased wound closure in the first 8 h of their application. These results are encouraging for the use of this alginate plantain extract formulation as an adjuvant for skin wound healing.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, further formulation needs to reduce those adverse effects. For example, curcuminoids microcapsule showed high effectiveness for the wound healing, diminishing adverse effects (Ang et al, 2019). Microencapsulation can delay absorption without affecting the bioavailability of the drug (Piva et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in microencapsulation of drugs for veterinary applications

Ahmad

Sun

et al. 2021

Vet Pharm & Therapeutics

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Microencapsulation is a process where very minute droplets or particles of solid or liquid or gas are trapped with a polymer to isolate the internal core material from external environmental hazards. Microencapsulation is applied mostly for flavor masking, fortification, and sustained and control release. It improves palatability, absorption, and bioavailability of drugs with good conformity. Microencapsulation has been widely studied in numerous drug delivery systems for human health. The application of microcapsules in the veterinary pharmaceutical sciences is increasing day by day. The treatment systems for humans and animals are likely to be similar, but more complex in the veterinary field due to the diversity of the species, breeds, body size, biotransformation rate, and other factors associated with animal physiology. Commercially viable, economically profitable, and therapeutically effective microencapsulated vaccine, anthelmintic, antibacterial, and other therapeutics have a great demand for livestock and poultry production. Nowadays, researchers emphasize the controlled and sustained‐release dosage form of drugs in the veterinary field. This paper has highlighted the microencapsulation materials, preparation techniques, characteristics, roles, and the application of microcapsules in veterinary medicine.

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Wound Healing Property of Curcuminoids as a Microcapsule-Incorporated Cream

Cited by 13 publications

References 52 publications

Review of Surfactant Use in Curcumin Drug Delivery System

Review of Surfactant Use in Curcumin Drug Delivery System

Antioxidant, Anti-Inflammatory Effects and Ability to Stimulate Wound Healing of a Common-Plantain Extract in Alginate Gel Formulations

Recent advances in microencapsulation of drugs for veterinary applications

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