Wound management in an era of increasing bacterial antibiotic resistance: A role for topical silver treatment

Wright, Jason; Lam, Kei Fong; Burrell, Robert E.

doi:10.1053/ic.1998.v26.a93527

Cited by 309 publications

(203 citation statements)

References 22 publications

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“…The antifungal and antibacterial effect of silver nanoparticles, even against antibiotic-resistant bacteria (Wright et al, 1994; has been demonstrated in in vitro conditions. Nowadays, silver compounds are routinely applied in a wide array of industrial and sanitary fields, such as coating of catheters and surgery material, the production of synthetic compounds for odontology, treatment of burn injuries, homeopathic medicine or water purification (Spencer, 1999;Klasen, 2000;Wadhera & Fung, 2005;Atiyeh et al, 2007;Hwang et al, 2007).…”

Section: Silver As Antimicrobialmentioning

confidence: 99%

Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Fondevila¹

2010

Silver Nanoparticles

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Among other uses, metallic silver and silver salts have currently been applied as antimicrobial agents in many aspects of medical industries, such as coating of catheters, dental resin composites and burn wounds, as well as in homeopathic medicine, with a minimal risk of toxicity in humans. However, their use in animal feeding as prebiotics have remain minimised, mostly because of the low cost antibiotics used as growth promoters in the second half of the XX Century. However, after the ban of this practice in the European Community, silver compounds appear as a potential alternative to other already in use, such as organic acids, oligosaccharides, plant extracts, etc. The major concerns about the safe use of an additive in animal feeding are its effective role as antimicrobial, acting selectively over potential pathogens but not over symbiotic microbial communities; a low toxic effect over the animal and its human consumer; and a low risk of environmental pollution. Metallic silver nanoparticles (up to 100 nm) allow for a higher antimicrobial effect than silver salts, are more resistant to deactivation by gastric acids and have a low absorption rate through the intestinal mucosa, thus minimising its potential risk of toxicity. Besides, it has been shown that the doses that promote animal physiological and productive effects are very low (20 to 40 ppm), especially compared to the 10 to 100-fold higher concentration used with other metallic compounds such as copper and zinc, thus precluding a harmful environmental effect. This chapter describes the reasons why silver nanoparticles could be applied to animal feeding, and provides with some available data in this regard. In any case, its registration as feed additive is a previous requisite before being applied in practical conditions.

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Section: Silver As Antimicrobialmentioning

confidence: 99%

Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Fondevila¹

2010

Silver Nanoparticles

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“…The Ag(I) ion is the active agent in many healthcare products such as silver-coated catheters (Dasgupta 1994), wound dressings (Adams et al 1999;Monafo and Freedman 1987) and creams for the treatment of burns (Wright et al 1998). Clinical investigations into the anti-bacterial nature of silver-containing dressings have revealed the potent activity of these materials against Pseudomonas aeruginosa (Ulker et al 2005;Olsen et al 2000), while the effective anti-bacterial activity of the dressings was also demonstrated against methicillin resistant Staphylococcus aureus and vancomycinresistant Pseudomonas species.…”

Section: Introductionmentioning

confidence: 99%

Exposure of Staphylococcus aureus to silver(I) induces a short term protective response

et al. 2012

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The Ag(I) ion has well established antibacterial and antifungal properties. Exposure of Staphylococcus aureus to MIC 80 AgNO 3 (3 lg/ml) lead to an increase in the activity of superoxide dismutase, glutathione reductase and catalase at 30 min but activity declined by 60 min. In addition, exposure of cells to this metal ion for 1 h lead to increased expression of a number of proteins such as elongation factors Ts, Tu and G, fructose-bisphosphate aldolase and triosephosphate isomerase but their expression declined following 4 h exposure. ATP binding cassette transporter protein and oligoendopeptidase F showed increased expression at 4 h. While Ag(I) is a potent antimicrobial agent this work demonstrates that S. aureus can mount a short-term protective response to exposure to the metal ion but that this is eventually overcome.

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“…18 There has also been discussion on the potential for increased resistance if there is indiscriminate use of silver dressings. [21][22][23] As there are so many different forms of impregnated silver dressings it is important to follow the manufacturer's guidelines. Sussman describes the range of silver dressings available in Australia.…”

Section: Silicone Dressingsmentioning

confidence: 99%

Wound Dressings Update

Weller

Sussman

2006

Pharmacy Practice and Res

114

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The availability of different types of wound dressings has increased in the last decade. Wound care practitioners have at their disposal an extensive range of dressings. Emerging dressing types include interactive/bioactive dressings and tissue-engineered skin substitutes. There is no one dressing that is suitable for the management of all types of chronic wounds and few are suited for the treatment of a single wound during all stages of the healing cycle. Successful wound management depends on an understanding of the healing process combined with knowledge of the properties of the various dressings available. Without such knowledge and careful assessment of all the factors that effect healing, dressing selection is likely to be arbitrary and ineffective, wasteful both in terms of time and physical resources. This article is an overview of some of the first-line and second-line interactive/bioactive dressings available. A synopsis of wound assessment and wound bed preparation will aid in choosing the appropriate dressings. It will also touch on advanced technologies including tissue-engineered skin substitutes. INTRODUCTIONNormal wound healing processes require restoration of epithelialisation and collagen formation. The first occurs by migration and proliferation of keratinocytes from the wound edges and by differentiation of stem cells from remaining hair follicle bulbs. The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. However, in the case of full-thickness burn injuries and chronic wounds such as pressure ulcers, venous ulcers and diabetic foot ulcers these processes are damaged and new technologies have been developed to improve the healing in these conditions. 1 The time it takes for a chronic wound to heal varies due to the idiosyncratic nature of each wound and inherent complex factors, which may impede healing. Infection, poor blood supply, immobility, diabetes, medicines, inadequate hydration and nutrition, trauma and poor wound management are causative or contributory factors. Tissue repair research and advances in moist wound healing pharmaceuticals have been pivotal in improving wound dressing technology. 2 Clinical experience suggests that wound healing is often impaired in the elderly. The elderly have a high prevalence of chronic leg and pressure ulcers and are vulnerable to skin tears that can be slow to heal due to decreased dermal thickness and the loss of proliferative capacity of the ageing dermis. 3 Chronic wounds represent a significant burden in human and economic costs. 4

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Wound management in an era of increasing bacterial antibiotic resistance: A role for topical silver treatment

Cited by 309 publications

References 22 publications

Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Exposure of Staphylococcus aureus to silver(I) induces a short term protective response

Wound Dressings Update

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