Wound repair and scarring of genital skin

Mirastschijski, Ursula; Jiang, Dongsheng; Rinkevich, Yuval; Karim, Refaat B.; Sorg, Heiko

doi:10.20517/2347-9264.2020.147

Cited by 4 publications

(9 citation statements)

References 45 publications

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“…In agreement with the literature [ 23 , 28 ], we found abundant elastic fibers in genital tissue in contrast to non-genital skin in our patient cohort which underwent plastic reconstructive surgery after urological interventions (biological men and women), gender reassignment surgery (trans-males and trans-females) and aesthetic genital surgery, with a total of 68 patients [ 11 ] ( Figure 3 ).…”

Section: Differences Between Genital and Non-genital Skinsupporting

confidence: 91%

“…In contrast to dermal fibroblasts, keratinocytes increase their aromatase secretion 400-fold upon mechanical wounding with subsequently enhanced estrogen levels [ 33 ]. Estrogens reduce the inflammatory reaction [ 43 ], oxidative stress and cellular apoptosis during wound repair [ 11 , 44 ]. Aromatase activity is age-dependent [ 45 ] and expressed in genital and non-genital fibroblasts [ 46 , 47 ].…”

Section: Differences Between Genital and Non-genital Skinmentioning

confidence: 99%

“…Significantly higher levels of AR, 5α-reductase and 17β-HSD were found in scrotal fibroblasts compared to blood cells [ 51 ]. Further information on hormone production and sex hormone receptor expression between non-genital and genital skin are found in detail elsewhere [ 11 , 15 ].…”

Section: Differences Between Genital and Non-genital Skinmentioning

confidence: 99%

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Genital Wound Repair and Scarring

2022

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Skin wound repair has been the central focus of clinicians and scientists for almost a century. Insights into acute and chronic wound healing as well as scarring have influenced and ameliorated wound treatment. Our knowledge of normal skin notwithstanding, little is known of acute and chronic wound repair of genital skin. In contrast to extra-genital skin, hypertrophic scarring is uncommon in genital tissue. Chronic wound healing disorders of the genitals are mostly confined to mucosal tissue diseases. This article will provide insights into the differences between extra-genital and genital skin with regard to anatomy, physiology and aberrant wound repair. In light of fundamental differences between genital and normal skin, it is recommended that reconstructive and esthetic surgery should exclusively be performed by specialists with profound expertise in genital wound repair.

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Section: Differences Between Genital and Non-genital Skinsupporting

confidence: 91%

Section: Differences Between Genital and Non-genital Skinmentioning

confidence: 99%

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Genital Wound Repair and Scarring

2022

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“…This process may be mediated by fascial matrix losing its elastic and hydrated properties and becoming a rigid fibrotic scar (Figure 2c). By contrast, wounds in oral mucosa and genital skin, where subcutaneous fascia is absent, heal with minimal scars [50,73]. The "dartos fascia" beneath genital skin has a striated carnosus muscle origin, and is not bona fide fascial tissue, further affirming that skin scarring is connected with the abundance and distribution of fascial tissue.…”

Section: Fibrotic Outcomes Of Fascia Repairmentioning

confidence: 99%

Furnishing Wound Repair by the Subcutaneous Fascia

Jiang

Rinkevich

2021

IJMS

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Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia’s unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.

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“…Scar tissue can occur after traumatic injuries (burns, etc.) as well as after surgery [23] . However, Mirastschijski et al [24] pointed out that not all regions are equal in terms of healing.…”

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confidence: 99%

Scar tissue prevention and revision - introduction to a special issue

Laloze¹,

Desmoulière²

2021

PAR

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The wound healing process is complex and, despite many advances in both fundamental research and plastic surgery, the mechanisms underlying tissue repair remain poorly understood.After surgery or trauma, the plastic surgeon needs to use all the means at his or her disposal to both obtain a stable scar and achieve the most aesthetic result. However, before this can be achieved, there is a long and sometimes difficult phase, lasting up to 18-24 months. Moreover, the surgeon will sometimes have to deal with complications related to either poor or excessive (defective or pathological) scarring. These complications, which are both physiological and psychological, particularly in aesthetic plastic surgery, are difficult to treat since there is at present no consensus, and they thus continue to represent a significant public health issue. Therefore, it is important to understand all of the closely interwoven aspects of healing, including structural and surgical aspects, for both prevention and revision of scarring.

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Wound repair and scarring of genital skin

Cited by 4 publications

References 45 publications

Genital Wound Repair and Scarring

Genital Wound Repair and Scarring

Furnishing Wound Repair by the Subcutaneous Fascia

Scar tissue prevention and revision - introduction to a special issue

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