Wpływ leczenia hipolipemicznego na wydzielanie cytokin prozapalnych w różnych grupach wiekowych pacjentów z cukrzycą typu 2 i dyslipidemią aterogenną

Krysiak, Robert; Gdula-Dymek, Anna; Marek, Bogdan

doi:10.5603/ep.a2016.0021

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Moreover, the impact of treatment on anti-inflammatory cytokines did not correlate with its action on hsCRP, irrespective of whether correlations were assessed at baseline or during treatment. The latter observation is in disagreement with our previous reports, which showed that the changes in proinflammatory cytokines were paralleled by a decrease in hsCRP [24][25][26]41]. On the basis of the obtained results, we may draw two conclusions.…”

Section: Tabela II Wpływ Krótkotrwałego Leczenia Perindoprilem I Telcontrasting

confidence: 99%

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

Gilowski¹,

Krysiak

Marek

2018

Endokrynologia Polska

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Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on the production of anti-inflammatory cytokines. Material and methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. The participants were divided into two groups treated with either perindopril (4 mg daily) or telmisartan (40 mg daily). Blood pressure, plasma lipids, glucose homeostasis markers, as well as plasma levels of uric acid, interleukins 4, 10, 13 (IL-4, IL-10, IL-13), and high sensitivity C-reactive protein (hsCRP) were measured at the beginning of the study and six weeks later. Results: Both perindopril and telmisartan reduced systolic (SBP) and diastolic blood pressure (DBP). Although both agents increased serum levels of IL-10, this effect was more pronounced in patients treated with telmisartan. Neither telmisartan nor perindopril affected circulating levels of uric acid, glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, IL-4, IL-13, and hsCRP. The effect of telmisartan on IL-10 slightly correlated with an improvement in insulin sensitivity. Treatment-induced changes in IL-10 did not correlate with hypotensive properties of perindopril and telmisartan. Conclusions: The obtained results indicate that angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers administered for a short period of time produce a relatively week effect on anti-inflammatory cytokines, limited to IL-10, and stronger for telmisartan than for perindopril.

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Section: Tabela II Wpływ Krótkotrwałego Leczenia Perindoprilem I Telcontrasting

confidence: 99%

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

Gilowski¹,

Krysiak

Marek

2018

Endokrynologia Polska

Self Cite

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Is fenofibrate the missing piece in COVID-19 management?

Mikhael

2020

Alexandria Journal of Medicine

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Adiponectin, lipids and atherosclerosis

Katsiki

Mantzoros

Mikhailidis

2017

Current Opinion in Lipidology

146

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Based on available data, adiponectin represents a multifaceted biomarker that may beneficially affect atherosclerosis, inflammation and insulin resistance pathways. However, there are conflicting results with regard to the associations between adiponectin levels and the prevalence and outcomes of cardiometabolic diseases. Further research on the potential clinical implications of adiponectin in the diagnosis and treatment of such diseases is needed.

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Wpływ leczenia hipolipemicznego na wydzielanie cytokin prozapalnych w różnych grupach wiekowych pacjentów z cukrzycą typu 2 i dyslipidemią aterogenną

Cited by 3 publications

References 35 publications

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

Is fenofibrate the missing piece in COVID-19 management?

Adiponectin, lipids and atherosclerosis

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