Wpływ suplementacji selenu na przywrócenie eutyreozy u chorych na subkliniczną niedoczynność tarczycy w wyniku autoimmunologicznego zapalenia tarczycy

Pirola, Ilenia; Gandossi, Elena; Agosti, Barbara; Delbarba, Andrea; Cappelli, Carlo

doi:10.5603/ep.2016.0064

Cited by 33 publications

(18 citation statements)

References 23 publications

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“…Despite that, in general, an improvement on levels of Se were observed [ 45 , 48 , 49 ]. In a prospective randomized controlled study by Pirola et al [ 50 ] involving 192 patients supplemented with Se for 4 months, euthyroidism was restored in 1/3 of subclinical hypothyroidism patients with autoimmune thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

et al. 2018

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Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto—ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35–74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval [CI], 3.8–7.0%). Compared with the first tertile of Se intake, the second (odds ratio [OR], 0.79; 95% CI, 0.65–0.96%) and third (OR, 0.72; 95% CI, 0.58–0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship.

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Section: Discussionmentioning

confidence: 99%

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

et al. 2018

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“…As summarized in Table 4 , several studies tested the effects of selenium in patients with autoimmune thyroiditis, due to its role in endocrine and immune functions, and modulation of the inflammatory response. Supplementation with selenium for one to 12 months in HT patients has given variable results on the endpoint measured (serum TPOAb levels), with more consistent and overall greater decline upon using the organic and more bioavailable form (selenomethionine) [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] . With a single exception (−56%) in a Greek study [19] , the decrease from baseline in serum TPOAb is not >44%, but in 5/13 studies is nil ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…A number of natural compounds/nutraceuticals are being used to treat autoimmune thyroid diseases (AIT), namely Graves’ disease (GD), GD-associated ophthalmopathy, HT and postpartum thyroiditis (PPT) [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] . Though an exhaustive list of these substances goes beyond the scope of the present paper, examples of them include omega-3-fatty acid-rich small oily fish [7] , [8] , L-carnitine [9] , [10] , [11] , selenium [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , and myoinositol [27] , [28] , [29] . However, the observation that prompted the present study stemmed from a fortuitous observation ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Marked improvement of thyroid function and autoimmunity by Aloe barbadensis miller juice in patients with subclinical hypothyroidism

Metro

Cernaro

Papa

et al. 2018

Journal of Clinical & Translational Endocrinology

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Some natural compounds decrease serum levels of thyroid autoantibodies, but results are inconsistent and thyroid function has been evaluated infrequently; moreover, the effects of Aloe on thyroid autoimmunity and function have been examined in very few studies. This study stems from the observation of one co-author, who has Hashimoto’s thyroiditis (HT)-related subclinical hypothyroidism (SCH). Upon checking her biochemical thyroid panel when taking daily Aloe barbardensis Miller juice (ABMJ) for thyroid-unrelated reasons, she noticed a decrease in serum thyroperoxidase autoantibodies (TPOAb) and thyrotropin (TSH) and an increase in serum free thyroxine (FT4). Based on this observation, we enrolled 30 consecutive HT women with levothyroxine-untreated SCH and high TPOAb levels. All of them took ABMJ (50 ml daily) for nine months and were tested for serum TSH, FT4, free triiodothyronine (FT3) and TPOAb. Measurements were performed at baseline and at months 3 and 9. TSH, FT4 and TPOAb improved significantly already at month 3 and further (−61%, +23% and −56%) at month 9. However, FT3 decreased significantly at month 3 (−16%) with no further decrease at month 9, so that the FT4:FT3 ratio increased significantly (+33% and + 49%). At baseline, 100% of women had TSH > 4.0 mU/L and TPOAb > 400 U/ml, but frequencies fell to 0% and 37%, respectively, at month 9. In contrast, a control group (namely, 15 untreated SCH women of comparable age and baseline levels of TSH, FT4, FT3 and TPOAb) had no significant changes in any index. We conclude that the daily intake of 100 ml ABMJ for 9 months in women with HT-related SCH decreases the burden of thyroid autoimmune inflammation. In addition, ABMJ rescues thyrocyte function, with decreased need for conversion of the prohormone T4 into the more active T3 through ABMJ-induced inhibition of T4 deiodination.

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“…There are different opinion regarding the impact on Se treatment on TSH values: Pirola et al [4] report the restoration of euthyroidism in patients with sub-clinical hypothyroidism after 4 months of 83 Selenomethionine µg/ day. The decrease of TSH was also mentionated by Winther et al [3], in a population of 361 subjects with autoimmune thyroiditis under Se for a period of 5 years.…”

Section: The Effect Of Selenium Supplementation On Tshmentioning

confidence: 99%

“…D1 and 2 convert thyroxine (T4) in tironine (T3). GPX1 and 4 protect thyreocites from damage caused by oxygen free radicals [4]. Selenium exhibits antiinflammatory and antioxidative actions and was shown to have an important role in lymphocytic chronic thyroiditis [5,6].…”

mentioning

confidence: 99%

Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis

Preda¹,

Vasiliu²,

Mihalache³

et al. 2017

Rev. Chim.

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To evaluate the effect of Selenium (Se) supplementation on: thyroid stimulating hormone (TSH), antiperoxidase antibodies (TPOAb) and glutathione peroxidise 1 (GPx1) in euthyroid subjects with autoimmune thyroiditis. 100 euthyroid women with autoimmune thyroiditis, from the same region, were randomized to receive daily 100 µg selenomethionine (n=50) or placebo (n=50) for 3 months. Serum concentrations of Se, TPOAb and TSH were performed in all patients at baseline and after 3 months. GPx1 activity was measured only in the interventional group before and after Se supplementation. At 3 months TSH presented a significant increase both in treated (2.49 vs. 2.09 UI/mL; p=0.001) and untreated groups (2.38 vs. 1.91 UI/mL; p=0.008). TPOAb decreased by 15.2% in patients treated with Se (p=0.002) and were not modified in untreated patients. At the end of the study Se and TPOAb were in direct insignificant correlation (r=+0.267, p=0.105). GPx1 did not show significant changes after Se supplementation. After 3 months of Se supplementation results showed a mild decrease of TPOAb and a weak negative correlation of these antibodies with Se levels. This suggests that Se treatment may improve the course of thyroid autoimmunity.

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Wpływ suplementacji selenu na przywrócenie eutyreozy u chorych na subkliniczną niedoczynność tarczycy w wyniku autoimmunologicznego zapalenia tarczycy

Cited by 33 publications

References 23 publications

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Marked improvement of thyroid function and autoimmunity by Aloe barbadensis miller juice in patients with subclinical hypothyroidism

Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis

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