WYBQ-4: a New Bactericidal Agent against Methicillin-Resistant Staphylococcus aureus

Abstract

Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Novel antimicrobial agents against MRSA are urgently being developed.

Isolation and Identification of Oral Bacteria and Characterization for biofilm formation and antibiotics resistance

“…These proteins have enzymatic activity such as Transpeptidases and Carboxypeptidases, as these proteins are targets for both (penicillins and cephalosporins), they work to change the target of anti-beta-lactams and thus produce bacterial resistance to these antibiotics. Most of the resistance shown by S. mutans strains is of plasmid origin, because plasmids play a role in the production of beta-lactam enzymes and are responsible for encoding some penicillin-binding proteins (PBPs) [29] The resistance of our isolates to nalidixic acid occurs after exposure to this antibiotic through chromosomal mutations that lead to a change in the target site represented by the enzyme DNA gyrase, which works to coil the DNA strand (Poirel et al, 2006). Resistance to chloramphenicol is also caused by the drug destruction by S. mutans isolates by the enzyme Chloramphenicol acetyl transferase [30].…”

Synthesis and biological evaluation of ruthenium complexes bearing the 1,2,4-triazole group as potential membrane-targeting antibacterial agents towards Staphylococcus aureus

“…Dalton Transactions icity was one of the indicators for assessing the toxicity of compounds; a higher lethal dose means greater drug safety. 51 A three-day toxicity experiment with an injection of different concentrations of Ru3 and vancomycin was conducted. As shown in Fig.…”